CONSEQUENCES OF TRADE LIBERALIZATION ON POVERTY AND INCOME DISTRIBUTION IN BRAZIL

This study evaluates the regional short run impacts of reduction in import tariffs in Brazil on poverty and distribution of income related to recent free trade area agreements. Results show that trade can reduce inter-regional income inequality, but poor urban households lose with trade liberalization. In order to compensate welfare losses for the poor, this study designs and evaluates a combination of trade and tax policies, which effectively contributes to improve welfare for poor urban households.International Relations/Trade,

High-fidelity correction of genomic uracil by human mismatch repair activities

<p>Abstract</p> <p>Background</p> <p>Deamination of cytosine to produce uracil is a common and potentially mutagenic lesion in genomic DNA. U•G mismatches occur spontaneously throughout the genome, where they are repaired by factors associated with the base excision repair pathway. U•G mismatches are also the initiating lesion in immunoglobulin gene diversification, where they undergo mutagenic processing by redundant pathways, one dependent upon uracil excision and the other upon mismatch recognition by MutSα. While UNG is well known to initiate repair of uracil in DNA, the ability of MutSα to direct correction of this base has not been directly demonstrated.</p> <p>Results</p> <p>Using a biochemical assay for mismatch repair, we show that MutSα can promote efficient and faithful repair of U•G mismatches, but does not repair U•A pairs in DNA. This contrasts with UNG, which readily excises U opposite either A or G. Repair of U•G by MutSα depends upon DNA polymerase δ (pol δ), ATP, and proliferating cell nuclear antigen (PCNA), all properties of canonical mismatch repair.</p> <p>Conclusion</p> <p>These results show that faithful repair of U•G can be carried out by either the mismatch repair or base excision repair pathways. Thus, the redundant functions of these pathways in immunoglobulin gene diversification reflect their redundant functions in faithful repair. Faithful repair by either pathway is comparably efficient, suggesting that mismatch repair and base excision repair share the task of faithful repair of genomic uracil.</p

A Relativistic Version of the Two-Level Atom in the Rest-Frame Instant Form of Dynamics

We define a relativistic version of the two-level atom, in which an extended atom is replaced by a point particle carrying suitable Grassmann variables for the description of the two-level structure and of the electric dipole. After studying the isolated system "atom plus the electro-magnetic field" in the electric-dipole representation as a parametrized Minkowski theory, we give its restriction to the inertial rest frame and the explicit form of the Poincar\'e generators. After quantization we get a two-level atom with a spin 1/2 electric dipole and the relativistic generalization of the Hamiltonians of the Rabi and Jaynes-Cummings models.Comment: 23 page

Information systems ethics – challenges and opportunities

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI linkThe purpose of this paper is to explore the ethical issues surrounding information systems (IS) practice with a view to encouraging greater involvement in this aspect of IS research. Information integrity relies upon the development and operation of computer-based information systems. Those who undertake the planning, development and operation of these information systems have obligations to assure information integrity and overall to contribute to the public good. This ethical dimension of information systems has attracted mixed attention in the IS academic discipline