8,991 research outputs found
Focus Point Supersymmetry Redux
Recent results from Higgs boson and supersymmetry searches at the Large
Hadron Collider provide strong new motivations for supersymmetric theories with
heavy superpartners. We reconsider focus point supersymmetry (FP SUSY), in
which all squarks and sleptons may have multi-TeV masses without introducing
fine-tuning in the weak scale with respect to variations in the fundamental
SUSY-breaking parameters. We examine both FP SUSY and its familiar special
case, the FP region of mSUGRA/CMSSM, and show that they are beautifully
consistent with all particle, astroparticle, and cosmological data, including
Higgs boson mass limits, null results from SUSY searches, electric dipole
moments, b -> s gamma, B_s -> mu^+ mu^-, the thermal relic density of
neutralinos, and dark matter searches. The observed deviation of the muon's
anomalous magnetic moment from its standard model value may also be explained
in FP SUSY, although not in the FP region of mSUGRA/CMSSM. In light of recent
data, we advocate refined searches for FP SUSY and related scenarios with heavy
squarks and sleptons, and we present a simplified parameter space to aid such
analyses.Comment: v3: 20 pages, 20 figures, minor numerical error in relic density
calculation corrected, fixed contours in figure
Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice
BACKGROUND Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice. METHODOLOGY/PRINCIPAL FINDINGS We examined whether heparin and enoxaparin influence APP processing and inhibit Aβ production in primary cortical cell cultures. Heparin and enoxaparin were incubated with primary cortical cells derived from Tg2576 mice, and the level of APP and proteolytic products of APP (sAPPα, C99, C83 and Aβ) was measured by western blotting. Treatment of the cells with heparin or enoxaparin had no significant effect on the level of total APP. However, both GAGs decreased the level of C99 and C83, and inhibited sAPPα and Aβ secretion. Heparin also decreased the level of β-secretase (BACE1) and α-secretase (ADAM10). In contrast, heparin had no effect on the level of ADAM17. CONCLUSIONS/SIGNIFICANCE The data indicate that heparin and enoxaparin decrease APP processing via both α- and β-secretase pathways. The possibility that GAGs may be beneficial for the treatment of AD needs further study.This work was funded by a project grant (490031) from the National Health and Medical Research Council of Australia (http://www.nhmrc.gov.au). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
Developing a Healthy Masculinities Program on a University Campus
Amid increased concerns about mental health, sexual violence, and substance use among college students, college campuses are looking toward developing targeted programming to help counteract these concerning trends. This practitioner paper highlights the development and impacts of a program at a Canadian institution, which focuses on healthy masculinity and identity development. Although still in the early stages, the feedback and observations are indicative of the powerful potential of this type of programming to improve healthy masculinity on college campuses
Weaning and management of weanling horses
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Feed tag information for commercial feeds for horses
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Evaluating rations for horses
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Nutritional considerations for broodmares
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Physical conditioning of horses
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
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