How the Marsden Fund has failed to achieve its full potential in the ESA panel: evidence of limitations in scope, biased outcomes, and futile applications

We have analysed the scope of proposals funded by the ‘Earth Sciences and Astronomy’ (ESA) panel of the Marsden Fund for the period 2004 to 2013. The scope of proposals funded is very limited and does not reflect the full remit of the panel: the successful projects fail to encompass the quality and quantity of research being undertaken within the Earth sciences community in New Zealand, and a number of sub-disciplines that seek to address fundamental and important problems within the Earth sciences are largely excluded. Moreover, nearly 50% of the funded proposals for the past decade have been made to just two institutions. To address these limitations, we suggest that: (1) a review is undertaken to examine and widen the scope of the panel to encompass sub-disciplines that demonstrably are never or rarely funded; (2) the composition of panel members be examined and modified to reflect a much wider scope of sub-disciplines within the Earth sciences; and (3) a review of the wide discrepancies in funding distributions on an institutional basis be undertaken. We want to ensure that a more representative range of sub-disciplines, in keeping with modern and realistic definitions of the Earth sciences, is funded through this panel, and so we also recommend the formation of a new panel for ‘Environmental and Earth-system Sciences’ that could encompass the research involving modern-day processes so that applications in these sub-disciplines are not pointless. In addition, it is clear that a very substantial increase in funding to the Marsden Fund must be sought

Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

Sister-chromatid cohesion is established during S phase when Eco1 acetylates cohesin. In budding yeast, Eco1 activity falls after S phase due to Cdk1-dependent phosphorylation, which triggers ubiquitination by SCF(Cdc4). We show here that Eco1 degradation requires the sequential actions of Cdk1 and two additional kinases, Cdc7-Dbf4 and the GSK-3 homolog Mck1. These kinases recognize motifs primed by previous phosphorylation, resulting in an ordered sequence of three phosphorylation events on Eco1. Only the latter two phosphorylation sites are spaced correctly to bind Cdc4, resulting in strict discrimination between phosphates added by Cdk1 and by Cdc7. Inhibition of Cdc7 by the DNA damage response prevents Eco1 destruction, allowing establishment of cohesion after S phase. This elaborate regulatory system, involving three independent kinases and stringent substrate selection by a ubiquitin ligase, enables robust control of cohesion establishment during normal growth and after stress

Matlab application for fitting progress curves to the Equilibrium Model

The general procedures for carrying out the necessary rate determinations required for accurate determination of the Equilibrium Model parameters, and fitting this data to the mathematical model to generate the parameters, are described in "Peterson, M.E., Daniel, R.M., Danson, M.J. & Eisenthal, R. (2007) The dependence of enzyme activity on temperature: determination and validation of parameters. Biochemical Journal, 402, 331-337". It should be borne in mind that the Equilibrium Model equation contains exponentials of exponentials – quite small deviations from ideal behaviour, or a failure to obtain true Vmax values, may lead to difficulty in obtaining reliable Equilibrium Model parameters

EPR spectroscopy of iron- and nickel-doped [ZnAl]-layered double hydroxides: modeling active sites in heterogeneous water oxidation catalysts

Iron-doped nickel layered double hydroxides (LDHs) are among the most active heterogeneous water oxidation catalysts. Due to inter-spin interactions, however, the high density of magnetic centers results in line-broadening in magnetic resonance spectra. As a result, gaining atomic-level insight into the catalytic mechanism via electron paramagnetic resonance (EPR) is not generally possible. To circumvent spin-spin broadening, iron and nickel atoms were doped into non-magnetic [ZnAl]-LDH materials and the coordination environments of the isolated Fe(III) and Ni(II) sites were characterized. Multifrequency EPR spectroscopy identified two distinct Fe(III) sites (S = 5/2) in [Fe:ZnAl]-LDH. Changes in zero field splitting (ZFS) were induced by dehydration of the material, revealing that one of the Fe(III) sites is solvent-exposed (i.e. at an edge, corner, or defect site). These solvent-exposed sites feature an axial ZFS of 0.21 cm⁻¹ when hydrated. The ZFS increases dramatically upon dehydration (to -1.5 cm⁻¹), owing to lower symmetry and a decrease in the coordination number of iron. The ZFS of the other (“inert”) Fe(III) site maintains an axial ZFS of 0.19-0.20 cm⁻¹ under both hydrated and dehydrated conditions. We observed a similar effect in [Ni:ZnAl]-LDH materials; notably, Ni(II) (S = 1) atoms displayed a single, small ZFS (±0.30 cm⁻¹) in hydrated material, whereas two distinct Ni(II) ZFS values (±0.30 and ±1.1 cm⁻¹) were observed in the dehydrated samples. Although the magnetically-dilute materials were not active catalysts, the identification of model sites in which the coordination environments of iron and nickel were particularly labile (e.g. by simple vacuum drying) is an important step towards identifying sites in which the coordination number may drop spontaneously in water, a probable mechanism of water oxidation in functional materials

Leafrollers (Lepidoptera) on berry crops in the Lower Fraser Valley, British Columbia

A survey of tortricid leafrollers and other lepidopterous larvae with leafrolling habits on berry crops in the Lower Fraser Valley, B.C., revealed 16 species feeding on blueberry, four on cranberry, eight on raspberry and four on strawberry. The most abundant species were <i>Choristoneura rosaceana</i>, <i>Spilonota ocellana</i>, <i>Archips rosanus</i> and <i>Cheimophila salicella</i> on blueberry, <i>Operophtera bruceata</i>, <i>C. rosaceana</i> and <i>Acleris comariana</i> on rapsberry, <i>Rhopobota naevana</i> on cranberry, and <i>A. comariana</i> on strawberry. Some of the species have apparently not been reported previously as feeding on some of the berry crops. Four species previously reported as pests of berry crops in the Lower Fraser Valley were not found. Fields treated with insecticides early in the season, whether or not for leafrollers, had lower leafroller populations than untreated fields. There is no objective evidence that leafroller populations were sufficient to cause economic injury to any of the crops. Subjective observations confirm the economic importance of leafroller damage to cranberry and suggest that economic injury may occur on blueberry

Final Report: Sensorpedia Phase 3

This report is a summary of the Oak Ridge National Laboratory s (ORNL s) Phase 3 development of Sensorpedia, a sensor information sharing platform. Sensorpedia is ORNL s Wikipedia for Sensors. The overall goal of Sensorpedia is to enable global scale sensor information sharing for scientific research, national security and defense, public health and safety, emergency preparedness and response, and general community awareness and outreach

"Recursive Preferences,"

We summarize the class of recursive preferences. These preferences fit naturally with recursive solution methods and hold the promise of generating new insights into familiar problems. Portfolio choice is used as an example

Bilayered Calcium Sulfate/Calcium Phosphate Space-Making Composites with Multiple Drug Delivery Capabilities

The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers degrade at separate rates, thereby providing sustained mechanical support and tailored drug delivery