4,732 research outputs found
The geometry of generalized loxodromic elements
We explore geometric conditions which ensure a given element of a finitely
generated group is, or fails to be, generalized loxodromic; as part of this we
prove a generalization of Sisto's result that every generalized loxodromic
element is Morse. We provide a sufficient geometric condition for an element of
a small cancellation group to be generalized loxodromic in terms of the
defining relations and provide a number of constructions which prove that this
condition is sharp.Comment: 22 pages. To appear in Ann. Inst. Fourie
The \u3cem\u3elet-7\u3c/em\u3e MicroRNA Family Members \u3cem\u3emir\u3c/em\u3e-48, \u3cem\u3emir\u3c/em\u3e-84, and mir-241 Function Together to Regulate Developmental Timing in \u3cem\u3eCaenorhabditis elegans\u3c/em\u3e
The microRNA let-7 is a critical regulator of developmental timing events at the larval-to-adult transition in C. elegans. Recently, microRNAs with sequence similarity to let-7 have been identified. We find that doubly mutant animals lacking the let-7 family microRNA genes mir-48 and mir-84 exhibit retarded molting behavior and retarded adult gene expression in the hypodermis. Triply mutant animals lacking mir-48, mir-84, and mir-241 exhibit repetition of L2-stage events in addition to retarded adult-stage events. mir-48, mir-84, and mir-241 function together to control the L2-to-L3 transition, likely by base pairing to complementary sites in the hbl-1 3′ UTR and downregulating hbl-1 activity. Genetic analysis indicates that mir-48, mir-84, and mir-241 specify the timing of the L2-to-L3 transition in parallel to the heterochronic genes lin-28 and lin-46. These results indicate that let-7 family microRNAs function in combination to affect both early and late developmental timing decisions
Report on an all-sky LIGO search for periodic gravitational waves in the S4 data
We report on an all-sky search with the LIGO detectors for periodic
gravitational waves in the frequency range 50-1000 Hz and having a negative
frequency time derivative with magnitude between zero and Hz/s. Data
from the fourth LIGO science run have been used in this search. Three different
semi-coherent methods of summing strain power were applied. Observing no
evidence for periodic gravitational radiation, we report upper limits on strain
amplitude and interpret these limits to constrain radiation from rotating
neutron stars.Comment: 5 pages, 1 figure, presented at Amaldi7, Sydney (July 2007
Searching for stochastic gravitational-wave background with the co-located LIGO interferometers
This paper presents techniques developed by the LIGO Scientific Collaboration
to search for the stochastic gravitational-wave background using the co-located
pair of LIGO interferometers at Hanford, WA. We use correlations between
interferometers and environment monitoring instruments, as well as time-shifts
between two interferometers (described here for the first time) to identify
correlated noise from non-gravitational sources. We veto particularly noisy
frequency bands and assess the level of residual non-gravitational coupling
that exists in the surviving data.Comment: Proceedings paper from the 7th Edoardo Amaldi Conference on
Gravitational Waves, held in Sydney, Australia from 8-14 July 2007. Accepted
to J. Phys.: Conf. Se
Most \u3cem\u3eCaenorhabditis elegans\u3c/em\u3e MicroRNAs are Individually Not Essential for Development or Viability
MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs or among gene pathways regulated by miRNAs. This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs
Signatures of HyperCharge Axions in Colliders
If in addition to the standard model fields, a new pseudoscalar field that
couples to hypercharge topological number density, the hypercharge axion,
exists, it can be produced in colliders in association with photons or Z
bosons, and detected by looking for its decay into photons or Z's. For a range
of masses below a TeV and coupling above a fraction of 1/TeV, existing data
from LEP II and the Tevatron can already put interesting constraints, and in
future colliders accessible detection range is increased significantly. The
hypercharge axion can help in explaining the matter-antimatter asymmetry in the
universe.Comment: 11 pages, 8 figures, uses axodraw.st
From genes to ecosystems: the ocean\u27s new frontier
The application of new molecular and genomic techniques to the ocean is driving a scientific revolution in marine microbiology. Discoveries range from previously unknown groups of organisms and novel metabolic pathways to a deeper appreciation of the fundamental genetic and functional diversity of oceanic microbes. The “oceanic genotype” represents only the potential biological capacity and sets an upper constraint on possible pathways and ecosystem rates. The realized structure and functioning of marine ecosystems, the “oceanic phenotype”, reflects the complex interactions of individuals and populations with their physical and chemical environment and with each other. A comprehensive exploitation of the wealth of new genomic data therefore requires a close synergy with interdisciplinary ocean research. Incorporating the information from environmental genomics, targeted process studies, and ocean observing systems into numerical models will improve predictions of the ocean\u27s response to environmental perturbations. Integrating information from genes, populations, and ecosystems is the next great challenge for oceanography
Correlation measurements in high-multiplicity events
Requirements for correlation measurements in high--multiplicity events are
discussed. Attention is focussed on detection of so--called hot spots,
two--particle rapidity correlations, two--particle momentum correlations (for
quantum interferometry) and higher--order correlations. The signal--to--noise
ratio may become large in the high--multiplicity limit, allowing meaningful
single--event measurements, only if the correlations are due to collective
behavior.Comment: MN 55455, 20 pages, KSUCNR-011-92 and TPI-MINN-92/47-T (revised).
Revised to correct typo in equation (30), and to fill in a few steps in
calculations. Now published as Phys. Rev. C 47 (1993) 232
Theoretical Study of Fluid Membranes of Spherical Topology with Internal Degrees of Freedom
A theoretical study of vesicles of topological genus zero is presented. The
bilayer membranes forming the vesicles have various degrees of intrinsic
(tangent-plane) orientational order, ranging from smectic to hexatic,
frustrated by curvature and topology. The field-theoretical model for these
`-atic' surfaces has been studied before in the low temperature (mean-field)
limit. Work presented here includes the effects of thermal fluctuations. Using
the lowest Landau level approximation, the coupling between order and shape is
cast in a simple form, facilitating insights into the behaviour of vesicles.
The order parameter contains vortices, whose effective interaction potential is
found, and renormalized by membrane fluctuations. The shape of the phase space
has a counter-intuitive influence on this potential. A criterion is established
whereby a vesicle of finite rigidity may be burst by its own in-plane order,
and an analogy is drawn with flux exclusion from a type-I superconductor.Comment: 34 pages + 4 Postscript figures. Uses RevTe
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