When is a butterfly like an elephant?

The behaviours of organisms as diverse as elephants and butterflies are affected by pheromones with identical or similar structures. Recent developments in the molecular biology of pheromone detection suggest why

Workshop on evaluating personal search

The first ECIR workshop on Evaluating Personal Search was held on 18th April 2011 in Dublin, Ireland. The workshop consisted of 6 oral paper presentations and several discussion sessions. This report presents an overview of the scope and contents of the workshop and outlines the major outcomes

The Relationship Between Prior Experiences in Mathematics and Pharmacy School Success

Objective. To assess students’ pre-pharmacy math experiences, confidence in math ability, and relationship between experiences, confidence, and grades in math-based pharmacy courses. Methods. A cross-sectional survey of first year to third year pharmacy students was conducted. Students reported type of pre-pharmacy math courses taken, when they were taken [high school (HS) vs. college] and year of HS and college graduation. Students rated their confidence in math ability using the previously validated 11-item Fogerty Math Confidence Scale (Cronbach alpha=0.92). Math grade point average (GPA), Pharmacy College Admission Test quantitative (PCAT quant) scores, and grades (calculations and kinetics) were obtained from transcripts and school records. Spearman correlation and multivariate linear regression were used to compare math experiences, confidence, and grades. Results. There were 198 students who reported taking math courses 7.1 years since HS graduation and 2.9 years since their last schooling prior to pharmacy school. Students who took math courses with more time since HS/last schooling had lower calculations and kinetics grades. Students reporting having taken more HS math courses had better calculations grades. Students with higher math GPA, and PCAT quant scores also had higher calculations and kinetics grades. Greater confidence in math ability was associated with higher calculations grades. In multivariate regressions, PCAT quant scores and years since HS independently predicted calculations grades, and PCAT quant scores independently predicted kinetics grades. Conclusion. The number of pre-pharmacy math courses and time elapsed since they were taken are important factors to consider when predicting a pharmacy student’s success in math-based pharmacy school courses

Involvement of Park and Recreation Professionals in Pedestrian Plans

Professionals from many different disciplines are finding innovative ways to work together to increase physical activity to help create healthier communities. One process that can provide a focal point for promoting physical activity by park and recreation professionals, land use and transportation planners, public health practitioners, and other stakeholders is the development and implementation of pedestrian plans. A pedestrian plan is a public document that lays out a community’s vision for future pedestrian activity, identifies the actions required to realize that vision, ties actions to funding sources, and describes implementation and use. The purpose of this study was to explore whether park and recreation professionals were involved in creating pedestrian plans and how park and recreation elements were represented in these plans. To answer this, we identified, collected, and conducted a content analysis of all pedestrian plans in North Carolina. Among the 41 regional, county, and municipal pedestrian plans, park and recreation professionals were mentioned in the plan 56% of the time. Seventy-one percent (n=29) had a vision statement; however, among those only five vision statements mentioned parks or recreation. In all five cases, when a plan contained a vision statement that mentioned parks or recreation, there was a park and recreation member involved in the development of the plan. A higher percent of plans with a park and recreation professional involved were more likely to list parks in their land use analysis (74% vs. 67%). Park master plans were mentioned in the pedestrian plans 29% of the time; however, a lower percent of plans with a park and recreational professional involved mentioned a park master plan (26% vs. 33%). Given the potential importance of pedestrian plans in creating connections for pedestrians, park and recreation professionals are encouraged to become involved in the pedestrian planning process if they are not already. Parks can offer opportunities for residents of diverse ages and cultures to come together to socialize and engage in health-promoting activities. Integrating a park and recreation perspective into a more comprehensive planning process can enhance access to parks, inform programs, support multiple community goals, facilitate efficient use of resources, and promote partnerships for greater sustainabilit

Visual hallucinations in the differential diagnosis of parkinsonism

Visual hallucinations (VH) occur commonly in Parkinson's disease (PD) and dementia with Lewy bodies (DLB) but are reported much less frequently in other neurodegenerative causes of parkinsonism, such as progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration syndrome. This clinical sign may be helpful when considering the differential diagnosis of patients with parkinsonism. The observation that VH may be specific to Lewy body pathology probably reflects a greater vulnerability of the visual systems to PD and DLB neurodegeneration compared with other diseases. Topographic differences in pathology are probably the major factor producing VH in Lewy body diseases, rather than neurophysiological changes that are specific to α-synuclein protein accumulation. VH correlate with pathology in the limbic system and more specifically the amygdale that is frequently affected in PD and DLB but relatively preserved in other forms of parkinsonism often misdiagnosed as PD. In this review, the published frequencies of VH in these different conditions are compared to put into context the notion of VH as a clinical clue to underlying Lewy body pathology

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione. Here we show that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involving the thioredoxin-like protein tryparedoxin. The presence of this new pathway was first detected using dialyzed soluble fractions of parasite extract. Tryparedoxin was identified as the intermediate molecule following purification, sequence analysis, antibody studies, and reconstitution of the redox cycle in vitro. The system can be readily saturated by trypanothione, the rate-limiting step being the interaction of trypanothione with the tryparedoxin. Both tryparedoxin and TcGPXI operate by a ping-pong mechanism. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides. TcGPXI contains a carboxyl-terminal tripeptide (ARI) that could act as a targeting signal for the glycosome, a kinetoplastid-specific organelle. Using immunofluorescence, tagged fluorescent proteins, and biochemical fractionation, we have demonstrated that TcGPXI is localized to both the glycosome and the cytosol. The ability of TcGPXI to use alternative electron donors may reflect their availability at the corresponding subcellular sites

Bayesian joint modeling of chemical structure and dose response curves

Today there are approximately 85,000 chemicals regulated under the Toxic Substances Control Act, with around 2,000 new chemicals introduced each year. It is impossible to screen all of these chemicals for potential toxic effects either via full organism in vivo studies or in vitro high-throughput screening (HTS) programs. Toxicologists face the challenge of choosing which chemicals to screen, and predicting the toxicity of as-yet-unscreened chemicals. Our goal is to describe how variation in chemical structure relates to variation in toxicological response to enable in silico toxicity characterization designed to meet both of these challenges. With our Bayesian partially Supervised Sparse and Smooth Factor Analysis (BS3FA) model, we learn a distance between chemicals targeted to toxicity, rather than one based on molecular structure alone. Our model also enables the prediction of chemical dose-response profiles based on chemical structure (that is, without in vivo or in vitro testing) by taking advantage of a large database of chemicals that have already been tested for toxicity in HTS programs. We show superior simulation performance in distance learning and modest to large gains in predictive ability compared to existing methods. Results from the high-throughput screening data application elucidate the relationship between chemical structure and a toxicity-relevant high-throughput assay. An R package for BS3FA is available online at https://github.com/kelrenmor/bs3fa