Experiences with and interpretation of standard test methods of building energy analysis tools

The authors separately apply ANSI/ASHRAE Standard 140-2001 to the simulation program TRNSYS, comparing not only their results but the differences in their simulation assumptions and in their interpretations of the Standard's test cases. Results of the application are presented for all three authors, showing that there is a significant amount of leeway within a complex simulation tool such asTRNSYS for users of different backgrounds to apply their own common simulating practices and still fall comfortably within the range of acceptability specified by such Standards. Included in the application results are results of sensitivity tests that demonstrate the relative importance of assumption differences

Converging on a recommended set of interpretations and assumptions in applying standard tests to energy analysis tools

The authors, having individually applied ANSI/ASHRAE Standard 140-2001 to the simulation program TRNSYS in a previous project, compare their results, simulation assumptions, and interpretations of the Standard's test cases to arrive at a conformed set of recommended practices. Sensitivities to individual assumptions are investigated and results of applying the conformed set of assumptions are presented

Combining different validation techniques for continuous software improvement - Implications in the development of TRNSYS 16

Validation using published, high quality test suites can serve to identify different problems in simulation software: modeling and coding errors, missing features, frequent sources of user confusion. This paper discusses the application of different published validation procedures during the development of a new TRNSYS version: BESTEST/ASHRAE 140 (Building envelope), HVAC BESTEST (mechanical systems) and IEA ECBCS Annex 21 / SHC Task 12 empirical validation (performance of a test cell with a very simple mechanical system). It is shown that each validation suite has allowed to identify different types of problems. Those validation tools were also used to diagnose and fix some of the identified problems, and to assess the influence of code modifications. The paper also discusses some limitations of the selected validation tools

Simulation synergy : expanding TRNSYS capabilities and usability

Developers of simulation packages are now able to take advantage of the increase in available desktop computing power to expand the capabilities and usability of their programs. This paper will illustrate these opportunities by discussing the different techniques the developers of the TRNSYS software package have used to try and create a synergy between TRNSYS and external programs and between the developers and users of the program

Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein.

BackgroundSleep disruptions occur early and frequently in Parkinson's disease (PD). PD patients also show a slowing of resting state activity. Alpha-synuclein is causally linked to PD and accumulates in sleep-related brain regions. While sleep problems occur in over 75% of PD patients and severely impact the quality of life of patients and caregivers, their study is limited by a paucity of adequate animal models.ObjectiveThe objective of this study was to determine whether overexpression of wildtype alpha-synuclein could lead to alterations in sleep patterns reminiscent of those observed in PD by measuring sleep/wake activity with rigorous quantitative methods in a well-characterized genetic mouse model.MethodsAt 10 months of age, mice expressing human wildtype alpha-synuclein under the Thy-1 promoter (Thy1-aSyn) and wildtype littermates underwent the subcutaneous implantation of a telemetry device (Data Sciences International) for the recording of electromyograms (EMG) and electroencephalograms (EEG) in freely moving animals. Surgeries and data collection were performed without knowledge of mouse genotype.ResultsThy1-aSyn mice showed increased non-rapid eye movement sleep during their quiescent phase, increased active wake during their active phase, and decreased rapid eye movement sleep over a 24-h period, as well as a shift in the density of their EEG power spectra toward lower frequencies with a significant decrease in gamma power during wakefulness.ConclusionsAlpha-synuclein overexpression in mice produces sleep disruptions and altered oscillatory EEG activity reminiscent of PD, and this model provides a novel platform to assess mechanisms and therapeutic strategies for sleep dysfunction in PD

Transforming Graph Representations for Statistical Relational Learning

Relational data representations have become an increasingly important topic due to the recent proliferation of network datasets (e.g., social, biological, information networks) and a corresponding increase in the application of statistical relational learning (SRL) algorithms to these domains. In this article, we examine a range of representation issues for graph-based relational data. Since the choice of relational data representation for the nodes, links, and features can dramatically affect the capabilities of SRL algorithms, we survey approaches and opportunities for relational representation transformation designed to improve the performance of these algorithms. This leads us to introduce an intuitive taxonomy for data representation transformations in relational domains that incorporates link transformation and node transformation as symmetric representation tasks. In particular, the transformation tasks for both nodes and links include (i) predicting their existence, (ii) predicting their label or type, (iii) estimating their weight or importance, and (iv) systematically constructing their relevant features. We motivate our taxonomy through detailed examples and use it to survey and compare competing approaches for each of these tasks. We also discuss general conditions for transforming links, nodes, and features. Finally, we highlight challenges that remain to be addressed

Letter from David McDowell to Hubert Creekmore

McDowell writes on Random House, Inc. letterhead from New York City to Creekmore in Jackson, Mississippi. He asks various questions about a novel that Creekmore is writing. Includes envelope.https://egrove.olemiss.edu/creekmore/1076/thumbnail.jp

Letter from David McDowell to Hubert Creekmore

McDowell writes on Random House, Inc. letterhead from New York City to Creekmore in Jackson, Mississippi, to send an a copy of Madeline\u27s cookbook, to ask for Tony Bowers\u27 address, and to discuss Creekmore\u27s novel in progress. Includes envelope.https://egrove.olemiss.edu/creekmore/1245/thumbnail.jp

Letter from David McDowell to Hubert Creekmore

McDowell writes on Random House, Inc. letterhead from New York City to Creekmore in Jackson, Mississippi. He writes to discuss publication and publicity for Creekmore\u27s novel, The Chain in the Heart. Includes envelope.https://egrove.olemiss.edu/creekmore/1137/thumbnail.jp