294 research outputs found
On the linear response and scattering of an interacting molecule-metal system
A many-body Green's function approach to the microscopic theory of
plasmon-enhanced spectroscopy is presented within the context of localized
surface-plasmon resonance spectroscopy and applied to investigate the coupling
between quantum-molecular and classical-plasmonic resonances in
monolayer-coated silver nanoparticles. Electronic propagators or Green's
functions, accounting for the repeated polarization interaction between a
single molecule and its image in a nearby nanoscale metal, are explicitly
computed and used to construct the linear-response properties of the combined
molecule-metal system to an external electromagnetic perturbation. Shifting and
finite lifetime of states appear rigorously and automatically within our
approach and reveal an intricate coupling between molecule and metal not fully
described by previous theories. Self-consistent incorporation of this
quantum-molecular response into the continuum-electromagnetic scattering of the
molecule-metal target is exploited to compute the localized surface-plasmon
resonance wavelength shift with respect to the bare metal from first
principles.Comment: under review at Journal of Chemical Physic
Optical Polarization Analogs in Inelastic Free Electron Scattering
Advances in the ability to manipulate free electron phase profiles within the
electron microscope have spurred development of quantum-mechanical descriptions
of electron energy loss (EEL) processes involving transitions between
phase-shaped transverse states. Here, we elucidate an underlying connection
between two ostensibly distinct optical polarization analogs identified in EEL
experiments as manifestations of the same conserved scattering flux. Our work
introduces a procedure for probing general tensorial target characteristics
including global mode symmetries and local polarization
Gender and ethnic differences in chronic myelogenous leukemia prognosis and treatment response: a single-institution retrospective study
<p>Abstract</p> <p>Background</p> <p>In the last decade the importance of ethnicity, socio-economic and gender differences in relation to disease incidence, diagnosis, and prognosis has been realized. Differences in these areas have become a major health policy focus in the United States. Our study was undertaken to examine the demographic and clinical features of chronic myelogenous leukemia (CML) patients presenting initially at the LAC+USC Medical Center, which serves an ethnically diverse population.</p> <p>Results</p> <p>Patients were evenly split by gender, overwhelmingly Hispanic (60.9%), and quite young (median age 39, range 17–65) compared with previously reported CML patient populations. Previous CML studies identified significant anemia (Hgb <12 g/dl), significant thrombocytosis (platelets >450 × 10<sup>9</sup>/l), and significant leukocytosis (WBC >50 × 10<sup>9</sup>/l) as significant adverse pretreatment prognostic factors. Using these indicators, in addition to the validated Hasford and Sokal scores, patients were stratified and analyzed via gender and ethnicity. A significantly greater proportion of women presented with significant anemia (p = 0.019, Fisher's exact test) and significant thrombocytosis (p = 0.041, Fisher's exact test) compared to men, although no differences were found in risk stratification or treatment response. MCV values for women were significantly (p = 0.02, 2-sample t-test) lower than those for men, suggesting iron deficiency anemia. Focusing on ethnicity, Hispanics as a whole had significantly lower Hasford risk stratification (p = 0.046, Fisher's exact test), and significantly greater likelihood (p = 0.016, Fisher's exact test) of achieving 3-month complete haematological remission (CHR) compared with non-Hispanics at LAC+USC Medical Center, though differences in treatment outcome were no longer significant with analysis limited to patients treated with first-line imatinib.</p> <p>Conclusion</p> <p>Female CML patients at LAC+USC Medical Center present with more significant adverse pre-treatment prognostic factors compared to men, but achieve comparable outcomes. Hispanic patients present with lower risk profile CML and achieve better treatment responses compared to non-Hispanic patients as a whole; these ethnic differences are no longer significant when statistical analysis is limited to patients given imatinib as first-line therapy. Our patients achieve response rates inferior to those of large-scale national studies. This constellation of findings has not been reported in previous studies, and is likely reflective of a unique patient population.</p
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Time-dependent quantum many-body theory of identical bosons in a double well: Early time ballistic interferences of fragmented and number entangled states
A time-dependent multiconfigurational self-consistent field theory is
presented to describe the many-body dynamics of a gas of identical bosonic
atoms confined to an external trapping potential at zero temperature from first
principles. A set of generalized evolution equations are developed, through the
time-dependent variational principle, which account for the complete and
self-consistent coupling between the expansion coefficients of each
configuration and the underlying one-body wave functions within a restricted
two state Fock space basis that includes the full effects of the condensate's
mean field as well as atomic correlation. The resulting dynamical equations are
a classical Hamiltonian system and, by construction, form a well-defined
initial value problem. They are implemented in an efficient numerical
algorithm. An example is presented, highlighting the generality of the theory,
in which the ballistic expansion of a fragmented condensate ground state is
compared to that of a macroscopic quantum superposition state, taken here to be
a highly entangled number state, upon releasing the external trapping
potential. Strikingly different many-body matter-wave dynamics emerge in each
case, accentuating the role of both atomic correlation and mean-field effects
in the two condensate states.Comment: 16 pages, 5 figure
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