Gene therapy for obstetric conditions

The first clinical trials of gene therapy in the 1990s offered the promise of a new paradigm for the treatment of genetic diseases. Over the decades that followed the challenges and setbacks which gene therapy faced often overshadowed any successes. Despite this, recent years have seen cause for renewed optimism. In 2012 Glybera™, an adeno-associated viral vector expressing lipoprotein lipase, became the first gene therapy product to receive marketing authorisation in Europe, with a licence to treat familial lipoprotein lipase deficiency. This followed the earlier licensing in China of two gene therapies: Gendicine™ for head and neck squamous cell carcinoma and Oncorine™ for late-stage nasopharyngeal cancer. By this stage over 1800 clinical trials had been, or were being, conducted worldwide, and the therapeutic targets had expanded far beyond purely genetic disorders. So far no trials of gene therapy have been carried out in pregnancy, but an increasing understanding of the molecular mechanisms underlying obstetric diseases means that it is likely to have a role to play in the future. This review will discuss how gene therapy works, its potential application in obstetric conditions and the risks and limitations associated with its use in this setting. It will also address the ethical and regulatory issues that will be faced by any potential clinical trial of gene therapy during pregnancy

Estimating the Knowledge-Capital Model of the Multinational Enterprise

What we term the firm includes three principal assumptions. First, services of knowledge-based and knowledge-generating activities, such as R&D, can be geographically separated from production and supplied to production facilities at low cost. Second, these knowledge-intensive activities are skilled-labor intensive relative to production. These characteristics give rise to vertical multinationals, which fragment production and locate activities according to factor prices and market size. Third, knowledge-based services have a (partial) joint-input characteristic that they can be supplied to additional production facilities at low cost. This characteristic gives rise to horizontal multinationals, which produce the same goods or services in multiple locations. In this paper, we note how this model predicts relationships between affiliate sales and country characteristics. We then subject these predictions to empirical tests.

Preliminary evaluation of offshore transport and storage of CO2

Bureau of Economic Geolog

Correlation Between Student Collaboration Network Centrality and Academic Performance

We compute nodal centrality measures on the collaboration networks of students enrolled in three upper-division physics courses, usually taken sequentially, at the Colorado School of Mines. These are complex networks in which links between students indicate assistance with homework. The courses included in the study are intermediate Classical Mechanics, introductory Quantum Mechanics, and intermediate Electromagnetism. By correlating these nodal centrality measures with students' scores on homework and exams, we find four centrality measures that correlate significantly with students' homework scores in all three courses: in-strength, out-strength, closeness centrality, and harmonic centrality. These correlations suggest that students who not only collaborate often, but also collaborate significantly with many different people tend to achieve higher grades. Centrality measures between simultaneous collaboration networks (analytical vs. numerical homework collaboration) composed of the same students also correlate with each other, suggesting that students' collaboration strategies remain relatively stable when presented with homework assignments targeting different skills. Additionally, we correlate centrality measures between collaboration networks from different courses and find that the four centrality measures with the strongest relationship to students' homework scores are also the most stable measures across networks involving different courses. Correlations of centrality measures with exam scores were generally smaller than the correlations with homework scores, though this finding varied across courses.Comment: 10 pages, 4 figures, submitted to Phys. Rev. PE

Who Wants an iPad? An Exercise In Rationing

This active learning exercise demonstrates the fundamental problem in economics that resources are scarce, while wants are relatively infinite.  Students are exposed to four mechanisms for rationing scare resources: markets, queue, coupons, and lottery.  An Apple iPad® pre-loaded with music, videos, and games is used as the good to be rationed. The uncertain value of the good allows for differences in willingness to pay.  Students are guided through an exercise that highlights the efficiency/equity tradeoffs in different allocation mechanisms by observing who gets the iPad in each round and whether any secondary market transactions occur to change the allocation

The Impact Of Business Faculty Attire On Student Perceptions And Engagement

Certainly not a new phenomenon, professors continue to strive to discover the magic elixir that will cause all students to become active participants in the learning process. It seems logical that if students find a topic interesting or pertinent to their career objectives, they will tend to take a more active role in a course. Perhaps as reasonable to assume, if instructors are engaging and have the respect of the class, students will naturally put forth more effort to master the material.  Prior studies have also shown that certain pedagogical devices and innovations, such as the usage of presentation technology, can positively impact student motivation. This study explored whether something as basic as the professor’s attire could also have a motivating effect on student perceptions and behavior in a college classroom setting. This paper summarizes the results of a survey pertaining to faculty dress that was administered to students enrolled in selected business courses at a mid-sized Midwestern university. Students were asked their opinion of whether the professional or unprofessional dress of the instructor would conceivably impact their own learning and effort. The survey results show that, in general, students perceive professional dress positively, and adjust their behavior accordingly

The Impact Of Instructor Attire On Student Perceptions Of Faculty Credibility And Their Own Resultant Behavior

Prior studies suggest that faculty members who are credible are more effective in the classroom in that they are evaluated more highly and their students achieve greater learning. This paper explores how the instructor’s attire impacts his or her perceived credibility, and how the students’ corresponding perception of instructor credibility impacts the students’ self-described behavior.  Questionnaires depicting instructors of both genders each wearing three different outfits, including casual, business casual and professional attire, are used to assess business student opinions regarding the academician’s credibility and the students’ resultant effort and learning.  The results indicate that faculty members can take comfort in that  their level of preparation, knowledge and ability to prepare students for a career do impact their credibility in the eyes of the students, no matter their choice of attire.  Instructor credibility, in turn, was found to have a significant positive relationship with all ten student effort and behavior variables that were examined.  In particular, credibility had the most impact on the student’s preparation for each class, attentiveness, appreciation for instructor effort, and respect for the instructor.  Positive significant relationships were also found between credibility and student evaluations of both the class and the instructor.&nbsp

Learning Over Time: A Literature Review and Case Study

This is the publisher's version, also found at http://ehis.ebscohost.com/ehost/detail?sid=311dd0cd-6ea1-4d5c-8de0-704b9260d750%40sessionmgr10&vid=1&hid=17&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=s3h&AN=2663392