The mentalistic basis of core social cognition: experiments in preverbal infants and a computational model

Evaluating individuals based on their pro- and anti-social behaviors is fundamental to successful human interaction. Recent research suggests that even preverbal infants engage in social evaluation; however, it remains an open question whether infants' judgments are driven uniquely by an analysis of the mental states that motivate others' helpful and unhelpful actions, or whether non-mentalistic inferences are at play. Here we present evidence from 10-month-olds, motivated and supported by a Bayesian computational model, for mentalistic social evaluation in the first year of life. A video abstract of this article can be viewed at http://youtu.be/rD_Ry5oqCY

Language control and parallel recovery of language in individuals with aphasia

Background: The causal basis of the different patterns of language recovery following stroke in bilingual speakers is not well understood. Our approach distinguishes the representation of language from the mechanisms involved in its control. Previous studies have suggested that difficulties in language control can explain selective aphasia in one language as well as pathological switching between languages. Here we test the hypothesis that difficulties in managing and resolving competition will also be observed in those who are equally impaired in both their languages even in the absence of pathological switching. Aims: To examine difficulties in language control in bilingual individuals with parallel recovery in aphasia and to compare their performance on different types of conflict task. Methods & procedures: Two right-handed, non-native English-speaking participants who showed parallel recovery of two languages after stroke and a group of non-native English-speaking, bilingual controls described a scene in English and in their first language and completed three explicit conflict tasks. Two of these were verbal conflict tasks: a lexical decision task in English, in which individuals distinguished English words from non-words, and a Stroop task, in English and in their first language. The third conflict task was a non-verbal flanker task. Outcomes & Results: Both participants with aphasia were impaired in the picture description task in English and in their first language but showed different patterns of impairment on the conflict tasks. For the participant with left subcortical damage, conflict was abnormally high during the verbal tasks (lexical decision and Stroop) but not during the non-verbal flanker task. In contrast, for the participant with extensive left parietal damage, conflict was less abnormal during the Stroop task than the flanker or lexical decision task. Conclusions: Our data reveal two distinct control impairments associated with parallel recovery. We stress the need to explore the precise nature of control problems and how control is implemented in order to develop fuller causal accounts of language recovery patterns in bilingual aphasia

Scaling K2. II. Assembly of a Fully Automated C5 Planet Candidate Catalog Using EDI-Vetter

We present a uniform transiting exoplanet candidate list for Campaign 5 of the K2 mission. This catalog contains 75 planets with seven multi-planet systems (five double, one triple, and one quadruple planet system). Within the range of our search, we find eight previously undetected candidates, with the remaining 67 candidates overlapping 51% of the study of Kruse et al. that manually vets candidates from Campaign 5. In order to vet our potential transit signals, we introduce the Exoplanet Detection Identification Vetter (EDI-Vetter), which is a fully automated program able to determine whether a transit signal should be labeled as a false positive or a planet candidate. This automation allows us to create a statistically uniform catalog, ideal for measurements of planet occurrence rate. When tested, the vetting software is able to ensure that our sample is 94.2% reliable against systematic false positives. Additionally, we inject artificial transits at the light-curve level of the raw K2 data and find that the maximum completeness of our pipeline is 70% before vetting and 60% after vetting. For convenience of future studies of occurrence rate, we include measurements of stellar noise (CDPP) and the three-transit window function for each target. This study is part of a larger survey of the K2 data set and the methodology that will be applied to the entirety of that set

Scaling K2. III. Comparable Planet Occurrence in the FGK Samples of Campaign 5 and Kepler

Using our K2 Campaign 5 fully automated planet-detection data set (43 planets), which has corresponding measures of completeness and reliability, we infer an underlying planet population model for the FGK dwarf sample (9257 stars). Implementing a broken power law for both the period and radius distributions, we find an overall planet occurrence of 1.00^(+1.07)_(−0.51) planets per star within a period range of 0.5–38 days. Making similar cuts and running a comparable analysis on the Kepler sample (2318 planets; 94,222 stars), we find an overall occurrence of 1.10 ± 0.05 planets per star. Since the Campaign 5 field is nearly 120 angular degrees away from the Kepler field, this occurrence similarity offers evidence that the Kepler sample may provide a good baseline for Galactic inferences. Furthermore, the Kepler stellar sample is metal-rich compared to the K2 Campaign 5 sample, so a finding of occurrence parity may reduce the role of metallicity in planet formation. However, a weak (1.5σ) difference, in agreement with metal-driven formation, is found when assuming the Kepler model power laws for the K2 Campaign 5 sample and optimizing only the planet occurrence factor. This weak trend indicates that further investigation of metallicity-dependent occurrence is warranted once a larger sample of uniformly vetted K2 planet candidates is made available

Scaling K2. III. Comparable Planet Occurrence in the FGK Samples of Campaign 5 and Kepler

Using our K2 Campaign 5 fully automated planet detection data set (43 planets), which has corresponding measures of completeness and reliability, we infer an underlying planet population model for the FGK dwarfs sample (9,257 stars). Implementing a broken power-law for both the period and radius distribution, we find an overall planet occurrence of $1.00^{+1.07}_{-0.51}$ planets per star within a period range of 0.5-38 days. Making similar cuts and running a comparable analysis on the Kepler sample (2,318 planets; 94,222 stars), we find an overall occurrence of $1.10\pm0.05$ planets per star. Since the Campaign 5 field is nearly 120 angular degrees away from the Kepler field, this occurrence similarity offers evidence that the Kepler sample may provide a good baseline for Galactic inferences. Furthermore, the Kepler stellar sample is metal-rich compared to the K2 Campaign 5 sample, thus a finding of occurrence parity may reduce the role of metallicity in planet formation. However, a weak ($1.5\sigma$) difference, in agreement with metal-driven formation, is found when assuming the Kepler model power-laws for the K2 Campaign 5 sample and optimizing only the planet occurrence factor. This weak trend indicates further investigation of metallicity dependent occurrence is warranted once a larger sample of uniformly vetted K2 planet candidates are made available.Comment: 17 pages; 10 figures; 1 table; accepted for publication in A

Revisiting the HIP 41378 System with K2 and Spitzer

We present new observations of the multiplanet system HIP 41378, a bright star (V = 8.9, K s = 7.7) with five known transiting planets. Previous K2 observations showed multiple transits of two Neptune-sized bodies and single transits of three larger planets (R P = 0.33R J , 0.47R J , 0.88R J ). K2 recently observed the system again in Campaign 18 (C18). We observe one new transit each of two of the larger planets d/f, giving maximal orbital periods of 1114/1084 days, as well as integer divisions of these values down to a lower limit of about 50 days. We use all available photometry to determine the eccentricity distributions of HIP 41378 d & f, finding that periods lesssim300 days require non-zero eccentricity. We check for overlapping orbits of planets d and f to constrain their mutual periods, finding that short periods (P < 300 days) for planet f are disfavored. We also observe transits of planets b and c with Spitzer/Infrared Array Camera (IRAC), which we combine with the K2 observations to search for transit timing variations (TTVs). We find a linear ephemeris for planet b, but see a significant TTV signal for planet c. The ability to recover the two smaller planets with Spitzer shows that this fascinating system will continue to be detectable with Spitzer, CHEOPS, TESS, and other observatories, allowing us to precisely determine the periods of d and f, characterize the TTVs of planet c, recover the transits of planet e, and further enhance our view of this remarkable dynamical laboratory

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

Background: Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome. Methods: In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intraventricular haemorrhage obstructing the 3rd or 4th ventricles, and no underlying pathology were adaptively randomly assigned (1:1), via a web-based system to receive up to 12 doses, 8 h apart of 1 mg of alteplase or 0·9% saline via the extraventricular drain. The treating physician, clinical research staff, and participants were masked to treatment assignment. CT scans were obtained every 24 h throughout dosing. The primary efficacy outcome was good functional outcome, defined as a modified Rankin Scale score (mRS) of 3 or less at 180 days per central adjudication by blinded evaluators. This study is registered with ClinicalTrials.gov, NCT00784134. Findings: Between Sept 18, 2009, and Jan 13, 2015, 500 patients were randomised: 249 to the alteplase group and 251 to the saline group. 180-day follow-up data were available for analysis from 246 of 249 participants in the alteplase group and 245 of 251 participants in the placebo group. The primary efficacy outcome was similar in each group (good outcome in alteplase group 48% vs saline 45%; risk ratio [RR] 1·06 [95% CI 0·88–1·28; p=0·554]). A difference of 3·5% (RR 1·08 [95% CI 0·90–1·29], p=0·420) was found after adjustment for intraventricular haemorrhage size and thalamic intracerebral haemorrhage. At 180 days, the treatment group had lower case fatality (46 [18%] vs saline 73 [29%], hazard ratio 0·60 [95% CI 0·41–0·86], p=0·006), but a greater proportion with mRS 5 (42 [17%] vs 21 [9%]; RR 1·99 [95% CI 1·22–3·26], p=0·007). Ventriculitis (17 [7%] alteplase vs 31 [12%] saline; RR 0·55 [95% CI 0·31–0·97], p=0·048) and serious adverse events (114 [46%] alteplase vs 151 [60%] saline; RR 0·76 [95% CI 0·64–0·90], p=0·002) were less frequent with alteplase treatment. Symptomatic bleeding (six [2%] in the alteplase group vs five [2%] in the saline group; RR 1·21 [95% CI 0·37–3·91], p=0·771) was similar. Interpretation: In patients with intraventricular haemorrhage and a routine extraventricular drain, irrigation with alteplase did not substantially improve functional outcomes at the mRS 3 cutoff compared with irrigation with saline. Protocol-based use of alteplase with extraventricular drain seems safe. Future investigation is needed to determine whether a greater frequency of complete intraventricular haemorrhage removal via alteplase produces gains in functional status