The Relationship Between Sexual Abuse and Disordered Eating: Applications of Narrative Therapy

While research has demonstrated a significant relationship between sexual abuse and the development of disordered eating behaviors, research on techniques to address disordered eating formed in this manner remains limited. Posttraumatic stress as well as internalized feelings of guilt, shame, and blame all contribute to the development of disordered eating in those who have experienced sexual violence. Narrative Therapy focuses on restorying an individual’s experienced and lived themes to make the creation of a new, healthy interpretation of trauma. Limited research has explored the potential application of restorying to populations experiencing disordered eating and sexual abuse trauma, independently. This conceptual article explores the potential application of Narrative Therapy with clients who have experienced sexual abuse and developed disordered eating behaviors. Implications in clinical practice as well as future research directions are presented. Keywords disordered eating, sexual abuse, narrative therapy, mental health, bulimi

Alcohol and HIV Decrease Proteasome and Immunoproteasome Function in Macrophages: Implications for Impaired Immune Function During Disease

Proteasomes (proteinase complexes, PR) and immunoproteasomes (IPR) degrade damaged proteins and affect protein processing required for antigen presentation by mononuclear phagocytes. These critical immune processes are attenuated during progressive HIV-1 infection and are affected by alcohol abuse. To investigate the mechanisms underlying these functional changes, we measured PR and CYP2E1 activities [an ethanol (EtOH) metabolizing enzyme] and reactive oxygen species (ROS) in human monocyte-derived macrophages (MDM) following HIV-1 infection and EtOH treatment. We observed progressive declines of PR activity and PR/IPR contents in HIV-1-infected MDM. PR activity and IPR expression increased after IFN-γ stimulation but reduced after HIV-1 infection. EtOH inhibited both IFN-γ -induced PR and IPR. Paradoxically, EtOH attenuated PR catalytic activity in infected MDM and suppressed viral replication. Elevated ROS followed EtOH exposure and paralleled decreased PR activity. The latter was restored by anti-oxidant. The data support the notion that HIV-1 infection and EtOH may work in concert to affect immune function including antigen presentation and thereby affect disease progression

Finite-Function-Encoding Quantum States

We investigate the encoding of higher-dimensional logic into quantum states. To that end we introduce finite-function-encoding (FFE) states which encode arbitrary $d$-valued logic functions and investigate their structure as an algebra over the ring of integers modulo $d$. We point out that the polynomiality of the function is the deciding property for associating hypergraphs to states. Given a polynomial, we map it to a tensor-edge hypergraph, where each edge of the hypergraph is associated with a tensor. We observe how these states generalize the previously defined qudit hypergraph states, especially through the study of a group of finite-function-encoding Pauli stabilizers. Finally, we investigate the structure of FFE states under local unitary operations, with a focus on the bipartite scenario and its connections to the theory of complex Hadamard matrices.Comment: Comments welcom

Structured Language Intervention for a Case of Advanced Frontotemporal Dementia

The semantic dementia (SD) form of frontotemporal lobar degeneration (FTLD) can cause deficits in naming and comprehension (Hodges, 2003). This study attempted to use an errorless learning approach in to preserve functional vocabulary in an advanced case of Frontotemporal Demenentia (FTD). EP received this treatment for 8 months. After those 8 months it was found that she initially increased in her naming abilities, then plateaued, and ultimately fell to her pre-treatment baseline. We concluded that are findings could be due to the progression of her disease but also due to a low amount of training due to vacation

Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End-Stage Renal Disease

Potential donors with congenital renal anomalies but normal renal function are often overlooked because of a possible increase in technical difficulty and complications associated with the surgery. However, as the waiting list for a deceased donor kidney transplant continues to grow, it is important to consider these kidneys for potential transplant. This paper describes the procurement of a crossed fused ectopic kidney, and subsequent parenchymal transection prior to transplantation as part of a combined simultaneous kidney pancreas transplant. The transplant was uncomplicated, and the graft had immediate function. The patient is now two years from transplant with excellent function

The Paleocene/Eocene boundary Global Standard Stratotype-section and Point (GSSP): Criteria for Characterisation and Correlation

The choice of a Paleocene/Eocene (P/E) Global Standard Stratotype-section and Point (GSSP) is complicated by the fact that there exists confusion on the exact denotation of the Paleocene and Eocene Series and their constituent lower rank (stage) units. While we can now resolve this problem by recourse to rigorous historical analysis, actual placement of the GSSP is further exacerbated by an embarrassment of riches (in regards to 7 criteria suitable for characterising and correlating a PIE GSSP but which span a temporal interval of greater than 2 my). Following the precept that the boundaries between higher level chronostratigraphic units are to be founded upon the boundaries of their lowest constituent stages in a nested hierarchy, we note that one of the criteria providing global correlation potential (a stable isotope excursion in marine and terrestrial stratigraphies) lies at a stratigraphic level more than !my older than the base of the stratotypic Ypresian Stage to which the base of the Eocene Series has been subordinated until now. Lowering a chronostratigraphic unit by this extent risks a significant modification to the original geohistorical denotation of the Ypresian Stage and the Eocene Series. We discuss here four options that are open to Voting Members of the Paleogene Subcommission. One solution consists in adjusting slightly the base of the Ypresian Stage (and, thus, the Eocene Series) so as to be correlatable on the basis of the lowest occurrence/First Appearance Datum (LO/FAD) of the calcareous nannofossil species Tribrachiatus.digitalis. Another solution would be to decouple series and stages so that the Ypresian Stage remains essentially unaltered but the base of tbe Eocene is relocated so as to be correlated on the basis of the Carbon Isotope Excursion (CIE). Two (compromise) solutions consist in erecting a new stage for the upper/terminal Paleocene (between the Thanetian [sensu Dollfus] and Ypresian Stages) characterised at its base by the global stable isotope excursion. The P/E GSSP may then be placed at the base of the stratotypic Ypresian Stage (thus preserving historical continuity and conceptual denotation and stability) or at the base of the newly erected stage (facilitating correlation of the base of the Eocene series, at least in principle). Both GSSPs should be placed in suitable marine stratigraphic sections yet to be determined but upon which there is considerable current investigative activity

Pedagogical Agents for Fostering Question-Asking Skills in Children

Question asking is an important tool for constructing academic knowledge, and a self-reinforcing driver of curiosity. However, research has found that question asking is infrequent in the classroom and children's questions are often superficial, lacking deep reasoning. In this work, we developed a pedagogical agent that encourages children to ask divergent-thinking questions, a more complex form of questions that is associated with curiosity. We conducted a study with 95 fifth grade students, who interacted with an agent that encourages either convergent-thinking or divergent-thinking questions. Results showed that both interventions increased the number of divergent-thinking questions and the fluency of question asking, while they did not significantly alter children's perception of curiosity despite their high intrinsic motivation scores. In addition, children's curiosity trait has a mediating effect on question asking under the divergent-thinking agent, suggesting that question-asking interventions must be personalized to each student based on their tendency to be curious.Comment: Accepted at CHI 202

Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes

Influenza A infection is a global disease that has been responsible for four pandemics over the last one hundred years. However, it remains poorly understood as to why some infected individuals succumb to life threatening complications whilst others recover and are relatively unaffected. Using gene-expression analysis of circulating leukocytes, here we show that the progression towards severe influenza A infection is characterised by an abnormal transcriptional reprogramming of cell cycle and apoptosis pathways. In severely infected humans, leukocyte gene-expression profiles display opposing cell cycle activities; an increased aberrant DNA replication in the G1/S phase yet delayed progression in the G2/M phase. In mild infection, cell cycle perturbations are fewer and are integrated with an efficient apoptotic program. Importantly, the loss of integration between cell cycle perturbations and apoptosis marks the transition from a mild viral illness to a severe, life threatening infection. Our findings suggest that circulating immune cells may play a significant role in the evolution of the host response. Further study may reveal alternative host response factors previously unrecognized in the current disease model of influenza

Incorporating Hydrologic Data and Ecohydrologic Relationships into Ecological Site Descriptions

The purpose of this paper is to recommend a framework and methodology for incorporating hydrologic data and ecohydrologic relationships in Ecological Site Descriptions (ESDs) and thereby enhance the utility of ESDs for assessing rangelands and guiding resilience-based management strategies. Resilience-based strategies assess and manage ecological state dynamics that affect state vulnerability and, therefore, provide opportunities to adapt management. Many rangelands are spatially heterogeneous or sparsely vegetated where the vegetation structure strongly influences infiltration and soil retention. Infiltration and soil retention further influence soil water recharge, nutrient availability, and overall plant productivity. These key ecohydrologic relationships govern the ecologic resilience of the various states and community phases on many rangeland ecological sites (ESs) and are strongly affected by management practices, land use, and disturbances. However, ecohydrologic data and relationships are often missing in ESDs and state-and-transition models (STMs). To address this void, we used literature to determine the data required for inclusion of key ecohydrologic feedbacks into ESDs, developed a framework and methodology for data integration within the current ESD structure, and applied the framework to a select ES for demonstrative purposes. We also evaluated the utility of the Rangeland Hydrology and Erosion Model (RHEM) for assessment and enhancement of ESDs based in part on hydrologic function. We present the framework as a broadly applicable methodology for integrating ecohydrologic relationships and feedbacks into ESDs and resilience-based management strategies. Our proposed framework increases the utility of ESDs to assess rangelands, target conservation and restoration practices, and predict ecosystem responses to management. The integration of RHEM technology and our suggested framework on ecohydrologic relations expands the ecological foundation of the overall ESD concept for rangeland management and is well aligned with resilience-based, adaptive management of US rangelands. The proposed enhancement of ESDs will improve communication between private land owners and resource managers and researchers across multiple disciplines in the field of rangeland management