Long-Term Persistence with Injectable Therapy in Relapsing-Remitting Multiple Sclerosis: An 18-Year Observational Cohort Study

<div><p>Disease modifying therapies (DMTs) reduce the frequency of relapses and accumulation of disability in multiple sclerosis (MS). Long-term persistence with treatment is important to optimize treatment benefit. This long-term, cohort study was conducted at the Calgary MS Clinic. All consenting adults with relapsing-remitting MS who started either glatiramer acetate (GA) or interferon-β 1a/1b (IFN-β) between January 1^st, 1996 and July 1^st, 2011 were included. Follow-up continued to February 1^st, 2014. Time-to-discontinuation of the initial and subsequently-prescribed DMTs (switches) was analysed using Kaplan-Meier survival analyses. Group differences were compared using log-rank tests and multivariable Cox regression models. Analysis included 1471 participants; 906 were initially prescribed GA and 565 were initially prescribed IFN-β. Follow-up information was available for 87%; 29 (2%) were lost to follow-up and 160 (11%) moved from Southern Alberta while still using DMT. Median time-to-discontinuation of all injectable DMTs was 11.1 years. Participants with greater disability at treatment initiation, those who started treatment before age 30, and those who started between 2006 and 2011 were more likely to discontinue use of all injectable DMTs. Median time-to-discontinuation of the initial DMT was 8.6 years. Those initially prescribed GA remained on treatment longer. Of 610 participants who discontinued injectable DMT, 331 (54%) started an oral DMT, or a second-line DMT, or resumed injectable DMT after 90 days. Persistence with injectable DMTs was high in this long-term population-based study. Most participants who discontinued injectable DMT did not remain untreated. Further research is required to understand treatment outcomes and outcomes after stopping DMT.</p></div

Kaplan-Meier and multivariable Cox regression analysis of potential factors associated with time-to-discontinuation of all first-line DMTs and the initial DMT prescribed.

<p>DMT = disease modifying therapy; EDSS = Expanded Disability Status Scale; GA = glatiramer acetate; IFN-β = interferon-beta; y = years, GOF = goodness-of-fit; n = 1465 in multivariable models.</p><p>^aLog-rank test.</p><p>^bWald test from multivariable Cox regression model adjusted for all covariates.</p><p>^cPer one-unit increase in MS duration.</p><p>Kaplan-Meier and multivariable Cox regression analysis of potential factors associated with time-to-discontinuation of all first-line DMTs and the initial DMT prescribed.</p