Reforming the Administrative Procedure Act: Democracy Index Rulemaking

This Essay argues that the current regime of administrative law should be changed by creating legal incentives for agencies to involve the public in the rulemaking process via democracy index rulemaking. Democracy index rulemaking would create a clear incentive for agencies to involve the public by requiring that the more participation that occurred during the rulemaking process, the more deference that such an agency rule would receive in court. An agency could receive this deference by using normal notice and comment procedures and receiving a large number of relevant and non-repetitive comments on a proposed rule, with the precise amount of deference then tied to the number of comments received. Alternatively, the agency could use a special procedure, called deliberative notice and comment, which would involve jury deliberations (involving a set of juries composed of stakeholders as well as of members of the general public) regarding the proposed administrative rule. An agency using this special democratic process would guarantee itself deference. Either way, democracy index rulemaking would create a system that would encourage public participation, with all of its virtues, while at the same time avoiding many of the negatives of other regimes of public participation

The Narrowing of Federal Power By the American Political Capital

This Essay--prepared for a symposium hosted by the William & Mary Bill of Rights Journal on the future of the District of Columbia--argues that American federal power can be better understood by considering the features of the metropolitan area that houses the most important parts of the American federal government. In other American metropolitan areas and in most capital metropolitan areas elsewhere in the world, local life features multiple and diverse industries. Washington is the metropolitan area that houses the most important parts of the American federal government, and Washington is dominated by the government and related industries. Washington is, in other words, a political capital. The ambition of this Essay is to make a descriptive point related to the status of Washington as a political capital. Because of its location in a metropolitan area dominated by a single industry, federal officials and those whom federal officials interact with are a narrower slice of the large and diverse American republic. While the American Constitution might permit a range of federal outcomes, the American political capital narrows that range of outcomes. This narrowing has a number of implications. On the one hand, the American system is less responsive to the range of interests existing in the United States. On the other hand, the American political capital plays a particularly important role in limiting the access by, and creation of, damaging private or governmental forces

The stochastic behavior of a molecular switching circuit with feedback

Background: Using a statistical physics approach, we study the stochastic switching behavior of a model circuit of multisite phosphorylation and dephosphorylation with feedback. The circuit consists of a kinase and phosphatase acting on multiple sites of a substrate that, contingent on its modification state, catalyzes its own phosphorylation and, in a symmetric scenario, dephosphorylation. The symmetric case is viewed as a cartoon of conflicting feedback that could result from antagonistic pathways impinging on the state of a shared component. Results: Multisite phosphorylation is sufficient for bistable behavior under feedback even when catalysis is linear in substrate concentration, which is the case we consider. We compute the phase diagram, fluctuation spectrum and large-deviation properties related to switch memory within a statistical mechanics framework. Bistability occurs as either a first-order or second-order non-equilibrium phase transition, depending on the network symmetries and the ratio of phosphatase to kinase numbers. In the second-order case, the circuit never leaves the bistable regime upon increasing the number of substrate molecules at constant kinase to phosphatase ratio. Conclusions: The number of substrate molecules is a key parameter controlling both the onset of the bistable regime, fluctuation intensity, and the residence time in a switched state. The relevance of the concept of memory depends on the degree of switch symmetry, as memory presupposes information to be remembered, which is highest for equal residence times in the switched states. Reviewers: This article was reviewed by Artem Novozhilov (nominated by Eugene Koonin), Sergei Maslov, and Ned Wingreen.Comment: Version published in Biology Direct including reviewer comments and author responses, 28 pages, 7 figure

On vv--domains and star operations

Let $\ast$ be a star operation on an integral domain $D$. Let \f(D) be the set of all nonzero finitely generated fractional ideals of $D$. Call $D$ a $\ast$--Pr\"ufer (respectively, $(\ast, v)$--Pr\"ufer) domain if $(FF^{-1})^{\ast}=D$ (respectively, $(F^vF^{-1})^{\ast}=D$) for all F\in \f(D). We establish that $\ast$--Pr\"ufer domains (and $(\ast, v)$--Pr\"ufer domains) for various star operations $\ast$ span a major portion of the known generalizations of Pr\"{u}fer domains inside the class of $v$--domains. We also use Theorem 6.6 of the Larsen and McCarthy book [Multiplicative Theory of Ideals, Academic Press, New York--London, 1971], which gives several equivalent conditions for an integral domain to be a Pr\"ufer domain, as a model, and we show which statements of that theorem on Pr\"ufer domains can be generalized in a natural way and proved for $\ast$--Pr\"ufer domains, and which cannot be. We also show that in a $\ast$--Pr\"ufer domain, each pair of $\ast$-invertible $\ast$-ideals admits a GCD in the set of $\ast$-invertible $\ast$-ideals, obtaining a remarkable generalization of a property holding for the "classical" class of Pr\"ufer $v$--multiplication domains. We also link $D$ being $\ast$--Pr\"ufer (or $(\ast, v)$--Pr\"ufer) with the group Inv$^{\ast}(D)$ of $\ast$-invertible $\ast$-ideals (under $\ast$-multiplication) being lattice-ordered

Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants.

Perioperative management of patients treated with the non-vitamin K antagonist oral anticoagulants is an ongoing challenge. Due to the lack of good clinical studies involving adequate monitoring and reversal therapies, management requires knowledge and understanding of pharmacokinetics, renal function, drug interactions, and evaluation of the surgical bleeding risk. Consideration of the benefit of reversal of anticoagulation is important and, for some low risk bleeding procedures, it may be in the patient's interest to continue anticoagulation. In case of major intra-operative bleeding in patients likely to have therapeutic or supra-therapeutic levels of anticoagulation, specific reversal agents/antidotes would be of value but are currently lacking. As a consequence, a multimodal approach should be taken which includes the administration of 25 to 50 U/kg 4-factor prothrombin complex concentrates or 30 to 50 U/kg activated prothrombin complex concentrate (FEIBA®) in some life-threatening situations. Finally, further studies are needed to clarify the ideal therapeutic intervention

Paraísos fiscales

Los paraísos fiscales tienen sus orígenes a mediados del siglo XX, cuando países con escasos recursos atraían inversiones extranjeras a través de legislación flexible y permisiva en materia financiera y tributaria. Las razones y motivaciones por la que los individuos hacen uso de estos medios de elusión y evasión pueden resumirse en el hecho de evitar la tributación en los países en que son residentes. Esto trae aparejado inequidades en la tributación y reducción en la recaudación de los estados, sumando presión impositiva sobre los contribuyentes que efectivamente cumplen con sus obligaciones fiscales, dejando escapar a aquellos que utilizan la figura en cuestión para evitar el pago de tributos.Fil: Bafumo, Fernando David. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Castellino, Antonella. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Di Marco, Mariano Emir. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Fontana Mercado, Alejandro. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Tutera, Mauricio. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

The relationship between galaxy and dark matter halo size from z ∼ 3 to the present

We explore empirical constraints on the statistical relationship between the radial size of galaxies and the radius of their host dark matter haloes from z similar to 0.1-3 using the Galaxy And Mass Assembly (GAMA) and Cosmic Assembly Near Infrared Deep Extragalactic Legacy Survey (CANDELS) surveys. We map dark matter halo mass to galaxy stellar mass using relationships from abundance matching, applied to the Bolshoi-Planck dissipationless N-body simulation. We define SRHR equivalent to r(e)/R-h as the ratio of galaxy radius to halo virial radius, and SRHR lambda equivalent to r(e)/(lambda R-h) as the ratio of galaxy radius to halo spin parameter times halo radius. At z similar to 0.1, we find an average value of SRHR similar or equal to 0.018 and SRHR. similar or equal to 0.5 with very little dependence on stellar mass. Stellar radius-halo radius (SRHR) and SRHR lambda have a weak dependence on cosmic time since z similar to 3. SRHR shows a mild decrease over cosmic time for low-mass galaxies, but increases slightly or does not evolve formoremassive galaxies. We find hints that at high redshift (z similar to 2-3), SRHR. is lower for more massive galaxies, while it shows no significant dependence on stellar mass at z less than or similar to 0.5. We find that for both the GAMA and CANDELS samples, at all redshifts from z similar to 0.1-3, the observed conditional size distribution in stellar mass bins is remarkably similar to the conditional distribution of lambda R-h. We discuss the physical interpretation and implications of these results

RuleVis: Constructing Patterns and Rules for Rule-Based Models

We introduce RuleVis, a web-based application for defining and editing "correct-by-construction" executable rules that model biochemical functionality, which can be used to simulate the behavior of protein-protein interaction networks and other complex systems. Rule-based models involve emergent effects based on the interactions between rules, which can vary considerably with regard to the scale of a model, requiring the user to inspect and edit individual rules. RuleVis bridges the graph rewriting and systems biology research communities by providing an external visual representation of salient patterns that experts can use to determine the appropriate level of detail for a particular modeling context. We describe the visualization and interaction features available in RuleVisand provide a detailed example demonstrating how RuleVis can be used to reason about intracellular interactions

Non-equilibrium phase transitions in biomolecular signal transduction

We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework

The Population of Damped Lyman-alpha and Lyman Limit Systems in the Cold Dark Matter Model

Lyman limit and damped Lyman-alpha absorption systems probe the distribution of collapsed, cold gas at high redshift. Numerical simulations that incorporate gravity and gas dynamics can predict the abundance of such absorbers in cosmological models. We develop a semi-analytical method to correct the numerical predictions for the contribution of unresolved low mass halos, and we apply this method to the Katz et al. (1996) simulation of the standard cold dark matter model ($\Omega=1$, $h=0.5$, $\Omega_b=0.05$, $\sigma_8=0.7$). Using this simulation and higher resolution simulations of individual low mass systems, we determine the relation between a halo's circular velocity $v_c$ and its cross section for producing Lyman limit or damped absorption. We combine this relation with the Press-Schechter formula for the abundance of halos to compute the number of absorbers per unit redshift. The resolution correction increases the predicted abundances by about a factor of two at z=2, 3, and 4, bringing the predicted number of damped absorbers into quite good agreement with observations. Roughly half of the systems reside in halos with circular velocities v_c>100\kms and half in halos with 35\kms. Halos with v_c>150\kms typically harbor two or more systems capable of producing damped absorption. Even with the resolution correction, the predicted abundance of Lyman limit systems is a factor of three below observational estimates, signifying either a failure of standard CDM or a failure of these simulations to resolve the systems responsible for most Lyman limit absorption. By comparing simulations with and without star formation, we find that depletion of the gas supply by star formation affects absorption line statistics at $z>=2$ only for column densities exceeding $N_{HI}=10^{22} cm^{-2}$.Comment: AASlatex, 17 pages w/ 3 embedded ps figures. Submitted to Ap