Satisfaction with body image for early adolescent females: The impact of pubertal timing within different school environments

During adolescence dramatic physical changes take place which the individual must incorporate into his or her evolving body image. The impact of different school environments on this incorporation process is explored using data on 225 White females from a longitudinal study. Differences in physical characteristics between early, middle, and late developers were assessed each year. The effects of pubertal timing on satisfaction with body image dimensions and self-esteem were then explored for sixth- and seventh-graders within different school environments. Reference group theory was used to examine three alternative hypotheses. Early versus late onset of menarche had different effects on certain aspects of satisfaction with body image, depending on the school environment. Results support the strength of the cultural ideal of thinness for women, but no other hypothesis had consistent support. The findings indicated the need to consider a multiplicity of factors in relation to specific body image dimensions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45266/1/10964_2005_Article_BF02090319.pd

Physical attractiveness as a mediator of the impact of early pubertal changes for girls

The present study examined the effects of early pubertal development and physical attractiveness on the popularity, body image, and self-esteem of over 200 sixth-grade girls. Two rival hypotheses were explored. The first suggests that physically attractive girls, because of their more favorable social environment, will exhibit fewer psychosocial difficulties than unattractive girls during pubertal development. The second hypothesis argues that attractive girls will exhibit greater difficulty during pubertal transition because their self-image is more intimately connected with their physical appearance. Although there were no significant interactions between attractiveness and pubertal development for either popularity or body image, the second hypothesis was supported with respect to self-esteem. Specifically, developing attractive girls exhibited lower self-esteem than their unattractive counterparts. The results are discussed in terms of the relative vulnerability to bodily changes of girls differing in physical attractiveness.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45265/1/10964_2005_Article_BF02088640.pd

BMPER Mutation in Diaphanospondylodysostosis Identified by Ancestral Autozygosity Mapping and Targeted High-Throughput Sequencing

Diaphanospondylodysostosis (DSD) is a rare, recessively inherited, perinatal lethal skeletal disorder. The low frequency and perinatal lethality of DSD makes assembling a large set of families for traditional linkage-based genetic approaches challenging. By searching for evidence of unknown ancestral consanguinity, we identified two autozygous intervals, comprising 34 Mbps, unique to a single case of DSD. Empirically testing for ancestral consanguinity was effective in localizing the causative variant, thereby reducing the genomic space within which the mutation resides. High-throughput sequence analysis of exons captured from these intervals demonstrated that the affected individual was homozygous for a null mutation in BMPER, which encodes the bone morphogenetic protein-binding endothelial cell precursor-derived regulator. Mutations in BMPER were subsequently found in three additional DSD cases, confirming that defects in BMPER produce DSD. Phenotypic similarities between DSD and Bmper null mice indicate that BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development