Illustration of the Correlation Clustering using an example of the graph <i>G</i> with {+} and {-} edges colored in black and red respectively.

<p>In graph <i>G</i> the gray circles refer to nodes (e.g. gene names) and connecting lines to edges (E) with {+} and {-} values. Green and blue circles represent putative clusters.</p

Illustration of expression profile of <i>x</i> and <i>y</i> with following patterns: A) <i>x</i> and <i>y</i> have both high similarity based on absolute difference and <i>r</i>(<i>x</i>,<i>y</i>); B) <i>x</i> and <i>y</i> have low similarity based on absolute difference but high <i>r</i>(<i>x</i>,<i>y</i>); C) <i>x</i> and <i>y</i> have very low similarity based on absolute difference but high negative <i>r</i>(<i>x</i>,<i>y</i>).

<p>Illustration of expression profile of <i>x</i> and <i>y</i> with following patterns: A) <i>x</i> and <i>y</i> have both high similarity based on absolute difference and <i>r</i>(<i>x</i>,<i>y</i>); B) <i>x</i> and <i>y</i> have low similarity based on absolute difference but high <i>r</i>(<i>x</i>,<i>y</i>); C) <i>x</i> and <i>y</i> have very low similarity based on absolute difference but high negative <i>r</i>(<i>x</i>,<i>y</i>).</p

The overall ICC method workflow culminating with formation of the largest Interconnected Correlation Gene Cluster (ICGC).

<p>The overall ICC method workflow culminating with formation of the largest Interconnected Correlation Gene Cluster (ICGC).</p

Nsf1 was not nuclear under rich sulfur conditions.

<p>M2 <i>NSF1-GFP</i> cells transformed with pNIC96-mCherry-hphMX were pre-cultured in YNB S- medium to early log phase and shifted to fresh YNB S+ or YNB S- medium. Cells were monitored by fluorescence microscopy at the indicated times. The arrow (→) represents medium shift.</p

Distribution of the <i>z</i>-scores corresponding to all genes (a total of 5667 genes) with the empirical probability density function plotted as a red line.

<p>The probability (<i>p</i>) corresponds to probability density function of finding a particular <i>z</i>-score at a particular value. The calculated <i>z</i>-scores were derived from <i>r</i> values. These values were obtained from a comparison of the <i>NSF1</i> expression profile to that of every other gene in the dataset (r). The blue bars correspond to critical regions at 0.95</p

Nsf1 localized to the nucleus under limiting sulfur conditions.

<p>M2 <i>NSF1-GFP</i> cells transformed with pNIC96-mCherry-hphMX were pre-cultured in YNB S- medium to early log phase and shifted to fresh YNB S+ or YNB S- medium. Cells were monitored by fluorescence microscopy at the indicated times. The arrow (→) represents media shift.</p

Yangonindimers A-C, three new kavalactone dimers from <i>Piper methysticum</i> (kava)

<p>Three new kavalactone dimers, designated as yangonindimers A-C (<b>1</b>–<b>3</b>), along with one known analogue were isolated from the roots of <i>Piper methysticum</i>. Their structures were elucidated via extensive analysis of their 1D, 2D NMR and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units. Compounds <b>1</b>–<b>4</b> were evaluated for their cytotoxic activities against human tumour cell lines NCI-H46, SW480 and HepG2, but none showed significant activity.</p