41 research outputs found

    A method to objectively assess muscular disorders of the lumbar back associated with chronic low back pain

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    Thesis (M.S.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.Recent information regarding chronic low back pain indicates that approximately 80% of all cases are muscular in origin. However, presently available diagnostic techniques and prescribed treatments are often ineffective in detecting and remedying this common ailment. The research effort reported in this thesis involves an electromyographic techniques used to objectively evaluate abnormal back muscle interactions associated with low back pain. In order to measure the functional state of the trunk extensor muscles. myoelectric (ME) activity was monitored from multiple sites of the lumbar musculature during sustained, isometric contractions. The fatigue characteristics of each muscle were quantified by observing the spectral shift of the power spectrum of the ME signal. The resulting "fatigue patterns" thus represented the dynamic interaction of the synergistic back muscles. Differences in these patterns associated with low back disorders may represent functional disturbances. To obtain an indication of the force contribution of each muscle, their relative activity levels were also monitored. Multifactor analysis of variance (ANOVA) techniques demonstrated significantly higher fatigue rates in the back extensor muscles of back patients as compared to pain-free controls. With regard to overall strength, however, back patients and controls were remarkably similar. Possible explanations of the observed endurance deficiency in back patients are: 1) muscle atrophy resulting from low patient motivation and inactivity, or 2) higher precontraction metabolic concentrations in the erector spinae muscles of back patients caused by high resting tensions and frequent muscle spasm, or 3) compensation by healthy muscles in order to relieve and/or protect deficient and/or injured synergists. In conjunction with the above-described study involving back patients, additional research was performed using pain-free controls to investigate the ability of the erector spinae muscles to recover following a fatiguing contraction. Recovery was quantified by observing the time required for the ME power spectrum to return to it's initial state following fatigue. Preliminary findings suggest the existence a circulatory reactive mechanism occurring immediately following a high level, ischemia-producing contraction. Furthermore, the reproducability of the back assessment procedure was established by repeating the procedure on the same day and on adjacent days. The results maintained that the assessment procedure is reliable.2031-01-0

    An Economic Analysis of the Costs of Operating Livestock Trucking Firms in North Dakota

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    Demand and Price Analysis, Livestock Production/Industries,

    Learning in Goal Oriented Autonomous Systems

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    This report, prepared for the Computer Science Laboratory at SRI International, covers the development of a Learning component for PAGODA, a modular architecture for goal directed agents that explore an environment without need for constant commands from an operator. Two learning algorithms are presented and our algorithm implementations analyzed. The report highlights the changes made to PAGODA and the development challenges encountered. Additionally, several potential improvements to the PAGODA system are given

    A Microfluidic Cell Concentrator

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    Merton City Knowledge

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    This paper serves as a proposal to the London Borough of Merton as to why it should adopt a city planning and management concept called City Knowledge. The concept of City Knowledge is defined, explained and illustrated with examples from cities in Europe and the United States. It details how the idea is a change in the way a municipality should employ this scheme. Real life examples are used to show how City Knowledge could benefit the borough, with special attention to a case study involving safety in the Housing and Social Services Department. The situations are tailored in such a way that the reader can easily relate to them

    The VerIFAST: An integrated method for cell isolation and extracellular/intracellular staining

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    a Isolation and characterization of a specific subset of cells from a large heterogeneous population is necessary for studying rare subpopulations of cells. Existing methods require transfer or wash steps that risk causing loss of the rare cell population of interest. Integrated methods reduce loss, making these methods especially useful for reliable isolation of rare cell populations. In this report, we demonstrate the VerIFAST, a device that builds upon the simplified workflow of the Immiscible Filtration Assisted by Surface Tension (IFAST) to integrate a method for cellular isolation with methods for extra-and intracellular staining. First, a front-end purification step allows cells and unwanted particulates to passively settle out of the operational path of the paramagnetic particles, resulting in good efficiency of capture (.80%) and purity (.70%) with a single virtual wall traverse. Second, a Sieve Chamber is used downstream of the isolation chamber that removes excess unbound paramagnetic particles (PMPs) and performs complex multi-step washing procedures without centrifugation or transfer steps. Further, cellular staining can be performed in the device and is demonstrated for extracellular epithelial cell adhesion molecule (EpCAM), intracellular pan-cytokeratins, and Ki-67
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