Spin-Orbit and Tensor Forces in Heavy-quark Light-quark Mesons: Implications of the New Ds state at 2.32 GeV

We consider the spectroscopy of heavy-quark light-quark mesons with a simple model based on the non-relativistic reduction of vector and scalar exchange between fermions. Four forces are induced: the spin-orbit forces on the light and heavy quark spins, the tensor force, and a spin-spin force. If the vector force is Coulombic, the spin-spin force is a contact interaction, and the tensor force and spin-orbit force on the heavy quark to order $1/m_1m_2$ are directly proportional. As a result, just two independent parameters characterize these perturbations. The measurement of the masses of three p-wave states suffices to predict the mass of the fourth. This technique is applied to the $D_s$ system, where the newly discovered state at 2.32 GeV provides the third measured level, and to the $D$ system. The mixing of the two $J^P=1^+$ p-wave states is reflected in their widths and provides additional constraints. The resulting picture is at odds with previous expectations and raises new puzzles.Comment: 6 pages, 1 figur

The DESI Experiment, a whitepaper for Snowmass 2013

The Dark Energy Spectroscopic Instrument (DESI) is a massively multiplexed fiber-fed spectrograph that will make the next major advance in dark energy in the timeframe 2018-2022. On the Mayall telescope, DESI will obtain spectra and redshifts for at least 18 million emission-line galaxies, 4 million luminous red galaxies and 3 million quasi-stellar objects, in order to: probe the effects of dark energy on the expansion history using baryon acoustic oscillations (BAO), measure the gravitational growth history through redshift-space distortions, measure the sum of neutrino masses, and investigate the signatures of primordial inflation. The resulting 3-D galaxy maps at z<2 and Lyman-alpha forest at z>2 will make 1%-level measurements of the distance scale in 35 redshift bins, thus providing unprecedented constraints on cosmological models.Comment: 14 pages, 4 figures, a White Paper for Snowmass 201

Predicting Acute Urinary Retention in Patients with Elevated Post Void Residuals

Objectives: To perform a retrospective analysis in order to evaluate factors that may help predict which men with elevated PVRs that were at increased risk to develop AUR

4S-Hydroxylation of insulin at ProB28 accelerates hexamer dissociation and delays fibrillation

Daily injections of insulin provide lifesaving benefits to millions of diabetics. But currently available prandial insulins are suboptimal: The onset of action is delayed by slow dissociation of the insulin hexamer in the subcutaneous space, and insulin forms amyloid fibrils upon storage in solution. Here we show, through the use of non-canonical amino acid mutagenesis, that replacement of the proline residue at position 28 of the insulin B-chain (ProB28) by (4S)-hydroxyproline (Hzp) yields an active form of insulin that dissociates more rapidly, and fibrillates more slowly, than the wild-type protein. Crystal structures of dimeric and hexameric insulin preparations suggest that a hydrogen bond between the hydroxyl group of Hzp and a backbone amide carbonyl positioned across the dimer interface may be responsible for the altered behavior. The effects of hydroxylation are stereospecific; replacement of ProB28 by (4R)-hydroxyproline (Hyp) causes little change in the rates of fibrillation and hexamer disassociation. These results demonstrate a new approach that fuses the concepts of medicinal chemistry and protein design, and paves the way to further engineering of insulin and other therapeutic proteins

Detection of Bacterial Antigens and Alzheimer\u27s Disease-like Pathology in the Central Nervous System of BALB/c Mice Following Intranasal Infection with a Laboratory Isolate of Chlamydia pneumoniae

Pathology consistent with that observed in Alzheimer’s disease (AD) has previously been documented following intranasal infection of normal wild-type mice with Chlamydia pneumoniae (Cpn) isolated from an AD brain (96-41). In the current study, BALB/c mice were intranasally infected with a laboratory strain of Cpn, AR-39, and brain and olfactory bulbs were obtained at 1-4 months post-infection (pi). Immunohistochemistry for amyloid beta or Cpn antigens was performed on sections from brains of infected or mock-infected mice. Chlamydia-specific immunolabeling was identified in olfactory bulb tissues and in cerebrum of AR-39 infected mice. The Cpn specific labeling was most prominent at 1 month pi and the greatest burden of amyloid deposition was noted at 2 months pi, whereas both decreased at 3 and 4 months. Viable Cpn was recovered from olfactory bulbs of 3 of 3 experimentally infected mice at 1 and 3 months pi, and in 2 of 3 mice at 4 months pi. In contrast, in cortical tissues of infected mice at 1 and 4 months pi no viable organism was obtained. At 3 months pi, only 1 of 3 mice had a measurable burden of viable Cpn from the cortical tissues. Mock-infected mice (0 of 3) had no detectable Cpn in either olfactory bulbs or cortical tissues. These data indicate that the AR-39 isolate of Cpn establishes a limited infection predominantly in the olfactory bulbs of BALB/c mice. Although infection with the laboratory strain of Cpn promotes deposition of amyloid beta, this appears to resolve following reduction of the Cpn antigen burden over time. Our data suggest that infection with the AR-39 laboratory isolate of Cpn results in a different course of amyloid beta deposition and ultimate resolution than that observed following infection with the human AD-brain Cpn isolate, 96-41. These data further support that there may be differences, possibly in virulence factors, between Cpn isolates in the generation of sustainable AD pathology