Distribution of population sense-heritability inside and outside genes.

<p>Distribution of heritability estimated from all SNPs, SNPs inside genes and SNPs outside genes by chromosome for crystallised intelligence, fluid intelligence and cognitive decline.</p

Variance explained for top ten regions ranked by significance or LRT for crystallised and fluid intelligence and cognitive decline.

<p>^a heritability of region when full model fitting 11 variance components first ten independent (i.e. non overlapping) regions and rest of genome.</p><p>^b Only the best supported of multiple overlapping regions was fitted.</p

Population-sense regional heritability for each brain-measured intermediate phenotype within the top g_f associated region on chromosome 5.

<p>²_ps: estimated regional population-sense heritability, SE: estimated standard error of the regional population-sense heritability. P:p-value from the LRT test testing the significance of the genetic variance component. Tissue: brain region, h</p

Top 20 independent autosomal GWAS hits.

<p>Top 20 independent autosomal GWAS hits.</p

Distribution of hair loss by male pattern baldness polygenic score decile in the independent sample.

<p>Distribution of hair loss by male pattern baldness polygenic score decile in the independent sample.</p

Manhattan Plot of imputed autosomal GWAS and genotyped X chromosome of male pattern baldness (p-values truncated at 1x10^-150).

<p>Manhattan Plot of imputed autosomal GWAS and genotyped X chromosome of male pattern baldness (p-values truncated at 1x10^-150).</p

Genome wide thresholds for the Likelihood Ratio Test (LRT) derived from N permutations.

<p>Genome wide thresholds for the Likelihood Ratio Test (LRT) derived from N permutations.</p

Plot of likelihood ratio test for phenotypic variance explained by each of 10,908 regions (groups of 101 consecutive SNPS) (bars) and −log₁₀ P-values>2.7 for single SNP association (circles).

<p>Dashed line is 1% nominal significance threshold for LRT for individual regions, dotted line is 5% genome-wide significance threshold for individual regions obtained by permutation analysis. <b>A</b> crystallised intelligence n = 1791, <b>B</b> fluid intelligence n = 1706 , and <b>C</b> cognitive change n = 1602.</p

Pleiotropic regions affecting multiple traits.

<p>Pleiotropic regions affecting multiple traits.</p

Region on chromosome 5 significantly associated with fluid intelligence.

<p>Annotation from Ensembl genome browser.</p