Paradigm clashes and progress: a personal reflection on a 50-year association with ABCT

Why is ABCT a successful, vibrant, and growing association when most other professional associations are withering on the vine? Since the first annual meeting of the organization, which I was privileged to attend, I have witnessed repeated changes in direction as new paradigms were introduced and debated. The clashing of ideas in these debates in our Association over the years centered on such things as classical versus operant learning principles, cognitive versus behavioral modes of intervention, the introduction of a focus on modifying affect and emotion, and “third wave” approaches. Indeed the very founding of the organization was based on a fundamental paradigm clash with the prevailing psychoanalytic approaches in the 1960s. The fact that through it all the organization continues to thrive reflects the secret to our success and our fundamental strength, a reliance on the slow but inexorable process of science.Accepted manuscrip

Evidence for a neural model to evaluate symmetry in V1

50 years ago Hubel and Wiesel discovered simple and complex cells in V1, but there is still no consensus on their functional roles. It is agreed that complex cells are more often selective for direction of motion than simple cells, that there are differences in the way they combine information within their receptive fields, and that complex cells probably receive most of their input from simple cells, but what this serial hierarchy achieves is not understood. There is another puzzling dichotomy that we think is related, namely that of cross-correlation, which is widely accepted as the operation performed on the input image by simple cells, and auto-correlation, which some think underlies the perception of Glass patterns, and possibly motion. We propose the hypothesis that complex cells signal auto-correlations in the visual image, but to evaluate them they require the preliminary analysis done by simple cells, and also pinwheels - structures intervening between simple cells and complex cells that were quite unknown to Hubel and Wiesel. We shall first present psychophysical evidence, using a new kind of random dot display, which suggests that both cross-correlation and auto-correlation are performed in early vision. We then point to recent evidence on the micro-circuitry of pinwheels, and mappings of their intrinsic activity, which shows how pinwheels might enable complex cells to respond selectively to autocorrelations in the input image that activates the simple cells. Auto-correlation is a powerful tool for detecting symmetry, and many may be surprised by evidence that such an abstract property is detected so early in visual perception

Evidence for Auto-Correlation and Symmetry Detection in Primary Visual Cortex

The detectability of patterns in random dot arrays was measured as a function of dot density and compared with the statistical limit set by different methods of detecting the pattern. For filtering, cross-correlation, convolution, or template matching, the limit is expected to be inversely proportional to the square root of dot density. But for auto-correlation, which can detect symmetries of various types, the limit is unaffected by dot density under many conditions. Confirming previous results, we found that the coherence-threshold is often constant for Glass patterns, but the range of constancy depends on details of the display procedure. Coherence-thresholds were found to increase when the average number of dots expected at each location rose towards or exceeded a value of one; we therefore think it results from the non-linear effects of occlusion that occur when a later-programmed dot falls in the same location as an earlier one. To test this, these non-linear effects were prevented by arranging the luminance of each location to be directly proportional to the number of times that location was covered by a dot. Millions of dots can be used for these images, and they retain the streakiness of Glass patterns, while discrete dots disappear. The constant coherence threshold for detecting this streakiness is maintained over a huge range of dot densities, extending right down to the range where discrete dots become visible and up to patterns that are essentially full-tone images with no discrete dots. At threshold, all these patterns have similar auto-correlation functions, as we can see from the way both low dot-number Glass-patterns and these mega-dot, multi-tone, Glass-like images are formed. This startling fact raises the question whether primary visual cortex computes auto-correlations as well as, or even instead of, the local, Fourier-type, wavelet analysis of the currently popular paradigm

Anger: the unrecognized emotion in emotional disorders

Anger plays a prominent definitional role in some psychological disorders currently widely scattered across DSM‐5 categories (e.g., intermittent explosive disorder, borderline personality disorder). But the presence and consequences of anger in the emotional disorders (e.g., anxiety disorders, depressive disorders) remain sparsely examined. In this review, we examine the presence of anger in the emotional disorders and find that anger is elevated across these disorders and, when it is present, is associated with negative consequences, including greater symptom severity and worse treatment response. Based on this evidence, anger appears to be an important and understudied emotion in the development, maintenance, and treatment of emotional disorders.First author draf

Addressing neuroticism in psychological treatment

Neuroticism has long been associated with psychopathology and there is increasing evidence that this trait represents a shared vulnerability responsible for the development and maintenance of a range of common mental disorders. Given that neuroticism may be more malleable than previously thought, targeting this trait in treatment, rather than its specific manifestations (e.g., anxiety, mood, and personality disorders), may represent a more efficient and cost-effective approach to psychological treatment. The goals of the current manuscript are to (a) review the role of neuroticism in the development of common mental disorders, (b) describe the evidence of its malleability, and (c) review interventions that have been explicitly developed to target this trait in treatment. Implications for shifting the focus of psychological treatment to underlying vulnerabilities, such as neuroticism, rather than on the manifest symptoms of mental health conditions, are also discussed.First author draf

Modified brinley plots: advantages and disadvantages

Accepted manuscrip

A functional analysis of two transdiagnostic, emotion-focused interventions on nonsuicidal self-injury

OBJECTIVE: Nonsuicidal self-injury (NSSI) is prevalent and associated with clinically significant consequences. Developing time-efficient and cost-effective interventions for NSSI has proven difficult given that the critical components for NSSI treatment remain largely unknown. The aim of this study was to examine the specific effects of mindful emotion awareness training and cognitive reappraisal, 2 transdiagnostic treatment strategies that purportedly address the functional processes thought to maintain self-injurious behavior, on NSSI urges and acts. METHOD: Using a counterbalanced, combined series (multiple baseline and data-driven phase change) aggregated single-case experimental design, the unique and combined impact of these 2 4-week interventions was evaluated among 10 diagnostically heterogeneous self-injuring adults. Ecological momentary assessment was used to provide daily ratings of NSSI urges and acts during all study phases. RESULTS: Eight of 10 participants demonstrated clinically meaningful reductions in NSSI; 6 participants responded to 1 intervention alone, whereas 2 participants responded after the addition of the alternative intervention. Group analyses indicated statistically significant overall effects of study phase on NSSI, with fewer NSSI urges and acts occurring after the interventions were introduced. The interventions were also associated with moderate to large reductions in self-reported levels of anxiety and depression, and large improvements in mindful emotion awareness and cognitive reappraisal skills. CONCLUSIONS: Findings suggest that brief mindful emotion awareness and cognitive reappraisal interventions can lead to reductions in NSSI urges and acts. Transdiagnostic, emotion-focused therapeutic strategies delivered in time-limited formats may serve as practical yet powerful treatment approaches, especially for lower-risk self-injuring individuals.Dr. Barlow receives royalties from Oxford University Press, Guilford Publications Inc., Cengage Learning, and Pearson Publishing. Grant monies for various projects come from the National Institute of Mental Health (F31MH100761), the National Institute of Alcohol and Alcohol Abuse, and Colciencias (Government of Columbia Initiative for Science, Technology, and Health Innovation). Consulting and honoraria during the past several years have come from the Agency for Healthcare Research and Quality, the Foundation for Informed Medical Decision Making, the Department of Defense, the Renfrew Center, the Chinese University of Hong Kong, Universidad Catolica de Santa Maria (Arequipa, Peru), New Zealand Psychological Association, Hebrew University of Jerusalem, Mayo Clinic, and various American Universities. (F31MH100761 - National Institute of Mental Health; National Institute of Alcohol and Alcohol Abuse; Colciencias (Government of Columbia Initiative for Science, Technology, and Health Innovation))Accepted manuscrip

Cognitive-behavioral therapy for anxiety in Parkinson's disease

Parkinson's disease (PD) is characterized by motor symptoms, but nonmotor symptoms also significantly impair daily functioning and reduce quality of life. Anxiety is prevalent and debilitating in PD, but remains understudied and undertreated. Much affective research in PD focuses on depression rather than anxiety, and as such, there are no evidence-based treatments for anxiety in this population. Cognitive-behavioral therapy (CBT) has shown promise for treating depression in PD and may be efficacious for anxiety. This exploratory study implemented a multiple-baseline single-case experimental design to evaluate the utility and feasibility of CBT for individuals with PD who also met criteria for a DSM-5 anxiety disorder ( n = 9). Participants were randomized to a 2-, 4-, or 6-week baseline phase, followed by 12 CBT sessions, and two post treatment assessments (immediately post treatment and 6-week follow-up). Multiple outcome measures of anxiety and depression were administered weekly during baseline and intervention. Weekly CBT sessions were conducted in-person ( n = 5) or via secure videoconferencing ( n = 4). At post treatment, seven of the nine participants showed significant reductions in anxiety and/or depression, with changes functionally related to treatment and most improvements maintained at 6-week follow-up. Effects of CBT on secondary outcomes varied across participants, with preliminary evidence for reduction in fear of falling. Adherence and retention were high, as were treatment satisfaction and acceptability. The findings of this pilot study provide preliminary evidence for the utility of CBT as a feasible treatment for anxiety and comorbid depressive symptoms in PD and highlight the potential of telehealth interventions for mood in this population.Accepted manuscrip