Additional file 1: Figure S1. of Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells

Structure of the PSMB5 gene and mRNA (A). DNA chromatogram showing the location of PSMB5 Q62P mutation in exon 2 (B). 3D protein structure of the PSMB5 Q62P performed using Swiss Prot database, showing the location of the PSMB5 Q62P on the alpha helix (blue arrow). A previously reported PSMB5 mutation (Cys63) is shown (C). (PPTX 419 kb