Development of programs for computing characteristics of ultraviolet radiation

Efficient programs were developed for computing all four characteristics of the radiation scattered by a plane-parallel, turbid, terrestrial atmospheric model. They were developed (FORTRAN 4) and tested on the IBM /360 computers with 2314 direct access storage facility. The storage requirement varies between 200K and 750K bytes depending upon the task. The scattering phase matrix (or function) is expanded in a Fourier series whose number of terms depend upon the zenith angles of the incident and scattered radiations, as well as on the nature of aerosols. A Gauss-Seidel procedure is used for obtaining the numerical solution of the transfer equation

The effect of polypropylene fibres within concrete with regard to fire performance in structures

Purpose – The purpose of this paper is to examine the effect of various polypropylene fibre additions (types and volume) to concrete with regard to explosive spalling when subject to high temperatures similar to those experienced in building or tunnel fires. Design/methodology/approach – Medium strength concrete was manufactured with varying proportions of polypropylene fibres. Plain control samples were used to determine the original concrete strength and this was used as a benchmark following high temperature heat tests to evaluate the surface condition and final compressive strength. A pilot study was used to determine an appropriate heat source for the test. This was three Bunsen burners, however sufficient heat could not be generated within 150mm concrete cubes and the concrete was shown to be a significant insulator and fire protection for structural members. The concrete test cubes were tested in a saturated condition which may reflect conditions where concrete is used in an external environment and thus is subject to soaking. Findings – One hundred and fifty millimetre concrete cubes with and without fibres were placed into a furnace at 1,000°C. Explosive spalling was shown to be reduced with the use of polypropylene fibres but the final compressive strength of concrete was significantly reduced and had little residual structural value after a two hour period of heating. Research limitations/implications – As the concrete tested was saturated, this condition provided a worst case scenario with regards to the build up of hydrostatic and vapour pressure within the cube. A range of percentage moisture contents would produce a more evenly balanced view of the effects of fibres in concrete. A single grade of concrete was used for the test. As the permeability of concrete influences the rate at which steam can escape from the interior of a saturated concrete cube, testing a range of concrete strengths would show this aspect of material performance with regard to spalling and final residual strength. Further research is recommended with regard to moisture contents, strengths of concrete and a range of temperatures

मन्नू भंडारी के गघ साहित्य का मूल्यांकन

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Ecology of Chital (Axis axis) in Gir

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A non-main-sequence secondary in SY Cancri

Simultaneous spectroscopic and photometric observations of the Z Cam type dwarf nova SY Cancri were used to obtain absolute flux calibrations. A comparison of the photometric calibration with a wide slit spectrophotometric calibration showed that either method is equally satisfactory. A radial velocity study of the secondary star, made using the far red NaI doublet, yielded a mass ratio q = 0.68; this is very different from the value of 1.13 quoted in the literature. Using the new lower mass ratio, and constraining the mass of the white dwarf to be within reasonable limits, then leads to a mass for the secondary star that is substantially less than would be expected for its orbital period if it satisfied a main-sequence mass-radius relationship. We find a spectral type of M0 that is consistent with that expected for a main-sequence star of the low mass we have found. However, in order to fill its Roche lobe, the secondary must be significantly larger than a main sequence star of that mass and spectral type. The secondary is definitely not a normal main-sequence star.Comment: 13 pages, 9 figures, 6 tables, accepted for publication in MNRA

Drug-Excipient Compatibility Studies in Formulation Development: Current Trends and Techniques

The safety, efficacy, quality and stability of a formulation are the cornerstones of any new drug development process. In order to consistently maintain these attributes in a finished dosage form, it is important to have a comprehensive understanding of the physico-chemical characteristics of the active pharmaceutical ingredient (API), as well as all other components (e.g. excipients, manufacturing aids, packaging materials) of the drug product. In a new drug development process, a detailed characterization of the API and other formulation components is usually carried out during the preformulation stage. The preformulation stage involves characterization of several aspects of the API including solubility, dissolution, permeability, polymorph/salt screening, stability (solidstate and solution-state), ionization properties, particle size distribution, API-excipient compatibilities etc. [1]. Excipients are ubiquitous to virtually every pharmaceutical formulation, and facilitate the manufacture, stability, administration, delivery of the API, and/or provide other functionalities to the dosage form. Excipients are used to improve processing (e.g. improving powder flow [2, 3], powder compactibility [4-6] etc.), enhance aesthetics (e.g. identification, branding etc. [7]), optimize product performance (e.g. modified drug-release [8-11]), and/or to facilitate patient compliance (e.g. taste masking [12-15]). They may constitute anywhere from 1 to 99 % of the total formulation mass. Due to the intimate contact of the API with one or more excipients in a formulation, there exists a likelihood of physical and/or chemical interactions between them. Any such interactions may result in a negative impact on the physical, stability or performance attributes of the drug product [16, 17]. The choice of excipients is of crucial importance to avoid these negative effects, and to facilitate the development of a robust and an effective formulation [18-20]. Thus, for a rational selection of excipients, screening of excipient-API compatibility is recognized as an important aspect of formulation development. Moreover, the USFDA’s 21st century current Good Manufacturing Practices (cGMP) initiative and International Council on Harmonization (ICH) Q8 guidelines encourage the pharmaceutical manufacturers to apply Quality by Design (QbD) principles in their drug development process [21, 22]. These guidelines include expectations of a clear understanding of any interactions between the formulation components. Moreover, recent advances in various thermal and non-thermal analytical techniques have led to an improved efficiency in the detection, monitoring and prevention of the incompatibilities early in the drug development process [23, 24]. This article aims to provide a brief overview of the nature of drug-excipient incompatibilities; as well as current trends and techniques used to evaluate these compatibilities in formulation development

A solid dispersion based on milk-micelle as a drug-carrier for the enhancement of the aqueous solubility of ritonavir

The goal of present investigation was to evaluate the feasibility of formulating a solid-dispersion using milk-micelles as drug-carriers, to enhance the aqueous solubility of ritonavir

Afro-Caribbean Immigrant Faculty Experiences in the American Academy: Voices of an Invisible Black Population

Afro-Caribbean immigrants have been an integral part of the history and shaping of the United States since the early 1900s. This current study explores the experiences of five Afro-Caribbean faculty members at traditionally White institutions of higher education. Despite the historical presence and influence of Afro-Caribbean communities and the efforts within education systems to address the needs of Afro-Caribbean constituents, Afro-Caribbean faculty members continue to be rendered indiscernible in higher education and to be frequently and erroneously perceived as African–Americans. The study examines the lived experiences of these individuals in the hegemonic White spaces they occupy at their institutions with both White and Black populations. Through their narratives, issues of stereotyping, microaggression, and isolation are addressed. The participants also offer solutions to address these issues by university administrators, department heads, faculty development professionals, diversity officers, policy makers, and other stakeholders. The voices in this study shed light on an overlooked, misunderstood, and under-researched population within our faculty ranks in the American Academy

Investigation of the effect of atmospheric dust on the determination of total ozone from the earth's ultraviolet reflectivity measurements

Results are presented on the effect of atmospheric aerosols on the value of total ozone, in an atmospheric column of the terrestrial atmosphere, estimated from the simulated measurements of the ultraviolet radiation back scattered by the earth atmosphere models. Simulated measurements were used in five (configuration of the BUV experiment of Nimbus-4 satellite), and in six (configuration of the TOMS section of the SBUV/TOMS experiment on Nimbus-G) narrow spectral regions in the ultraviolet part of the spectrum