9 research outputs found
A Performance Analysis Framework for WiFi/WiMAX Heterogeneous Metropolitan Networks Based on Cross-Layer Design
The communication between network nodes within different protocol domains is often regarded simply as a black box with unknown configuration conditions in the path. We address network heterogeneity using a white box approach and focus on its interconnection processes. To achieve this purpose, a Performance Analysis Framework (PAF) is proposed which is composed of the formalization of the latter using process algebra (PA) and the corresponding teletraffic performance models. In this contribution, we target the IEEE 802.16 and IEEE 802.11 protocols. For the teletraffic models, we extend previous models for such scenario with the inclusion of the following protocol operational parameters (metrics): bit error rate (BER), packet error ratio (PER), and packet length (pl). From the framework teletraffic models, the optimal packet length (OPL), end to end throughput, delay, and packet loss are obtained. The PAF outperforms previous modeling solutions in terms of delay and throughput relative to NS3 simulation results. </jats:p
Ripensare modelli e prassi di valutazione della qualità nella scuola dell’infanzia. Una ricerca esplorativa nel campo della formative educational evaluation Rethinking Models and Practices of Quality Evaluation in the Kindergarten. An Explorative and Qualitative Research in the Field of "Formative Educational Evaluation"
L’articolo descrive il percorso triennale e alcuni principali risultati di una ricerca di educational evaluation condotta, nella prospettiva della ricerca-formazione (Becchi et.al., 1997; Lodini, Vannini, 2006), nella scuola dell’infanzia di un quartiere bolognese.
A partire da un uso problematico e critico della scala Sovasi (Harms, Clifford, 1994) e delle specifiche procedure metodologiche previste dal modello della valutazione formativa della qualità della scuola (Bondioli, Ferrari, 2004), la ricerca ha portato a diversi ordini di risultati, sul piano della valutazione sia esterna sia interna.
In merito alla valutazione esterna, sono stati osservati i profili Sovasi di 15 sezioni di scuola dell’infanzia, evidenziando le differenze fra i diversi plessi scolastici e individuando le prassi “di qualità” condivise che contraddistinguono le scelte progettuali e didattiche del quartiere e che costituiscono un patrimonio educativo per tutti i contesti 3-6 del Comune di Bologna.
In merito alla valutazione interna, sono state monitorate, tramite la scala Sovasi, le 15 sezioni, osservandone i progressivi miglioramenti e promuovendo – nei gruppi di insegnanti e grazie all’uso di specifici strumenti di supporto – prassi di riflessione e di riprogettazione.
La ricerca ha infine portato a riflettere criticamente sulla metodologia valutativa utilizzata e a individuare nuovi indicatori e aspetti procedurali utili alla messa a punto di un nuovo strumento di osservazione, complementare e non alternativo alla Scala Sovasi. Il percorso di formative educational evaluation si propone pertanto anche come una ricerca di tipo esplorativo-qualitativa (Lumbelli, 2006), preliminare ad una futura fase di verifica – su di un campione rappresentativo di sezioni di scuola dell’infanzia – della validità di una nuova ipotesi metodologica di valutazione della qualità della scuola dell’infanzia
The A431E mutation in PSEN1 causing Familial Alzheimer's Disease originating in Jalisco State, Mexico: An additional fifteen families
Immunologic and inflammatory processes are involved in the pathogenesis of acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM2). Human leukocyte antigen-G (HLA-G) is a negative regulator of the immune response. This study evaluates the 14 bp Del/Ins HLA-G polymorphism in ACS and DM2. Three hundred and seventy individuals from Western Mexico were recruited and categorized into three groups: ACS (86), DM2 without coronary complications (70), and healthy subjects (214). Genotyping of the 14 bp Del/Ins HLA-G polymorphism was performed by PCR and Native-PAGE. The most common risk factors were hypertension and overweight in ACS and DM2, respectively. The genetic distribution of the 14 bp Del/Ins HLA-G polymorphism showed no significant differences between groups (P ? 0.23). Nonetheless, the Ins/Ins genotype was associated with high blood pressure (HBP) in the DM2 group (OR c = 1.65, P = 0.02). The genetic recessive model showed similar findings (OR c = 3.03, P = 0.04). No association was found in ACS, with a P of 0.05; nevertheless, the prevalence of Ins/Ins carriers was quite similar to that found in the DM2-HBP group. The 14 bp Del/Ins HLA-G polymorphism was not a susceptibility factor for ACS or DM2; however, the Ins/Ins genotype might have contributed to the development of HBP in the studied groups. " 2014 Ilian Janet García-González et al.",,,,,,"10.1155/2014/898159",,,"http://hdl.handle.net/20.500.12104/45016","http://www.scopus.com/inward/record.url?eid=2-s2.0-84896873133&partnerID=40&md5=1030a197b7894a2fa74b129b6c6601f
Homocysteine, MTHFR C677T and A1298C polymorphisms, and clinical and biochemical variables in the mexican population [Homociste�na, polimorfismos MTHFR C677T, A1298C e vari�veis cl�nico-bioqu�micas em popula��o mexicana]
The objective of the current work was to analyze the relationship of serum homocysteine (Hcy) with MTHFR C677T and A1298C polymorphisms and clinical and biochemical variables in the Mexican population. Hcy (immunoassay) levels and polymorphism (PCR/RFLP) levels were determined in 102 individuals from the general population. The 677TT genotype showed significant association with body weight (r=0.012) and the 1298CC genotype tended to be associated with BMI (r?0.06). Serum levels of Hcy in women (51/102) were 8.33 �1.86 ?mol/L and in men (51/102) 11.64 � 4.15 ?mol/L. The Hcy was positively associated with body weight (r=0.004) and negatively with Hb and Hct (r=0.001). Higher levels of Hcy were found in smokers (r=0.009) and a tendency to hyperhomocysteinemia in alcoholics and in menopausal women. There was no association of Hcy with MTHFR C677T and A1298C polymorphisms, although the analysis with dominant inheritance model for the C677T polymorphism (TT + CT vs. CC) showed a semidominant effect (r<0.10). In this study, the presence of MTHFR C677T and A1298C polymorphisms did not represent a significant risk factor for hyperhomocysteinemia; however, those differences may point out the dependence of the relative levels of Hcy modified genotypes on various environmental factors
Theoretical study on the sequential hydroxylation of C82 fullerene based on Fukui function
Background. Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The-844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim of the study is to evaluate the association of-844 G>A PAI-1 polymorphism with ACS. Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS. Results. The most important risk factor in our population was hypertension, followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with ACS. The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of ACS dyslipidemic patients (OR = 1.99, P = 0.04). The A allele and AA genotype of-844 polymorphism of PAI-1 gene are risk factors for ACS. The AA genotype might be associated with the development of dyslipidemia in ACS patients. " 2015 Ilian Janet García-González et al.",,,,,,"10.1155/2015/460974",,,"http://hdl.handle.net/20.500.12104/45324","http://www.scopus.com/inward/record.url?eid=2-s2.0-84924270260&partnerID=40&md5=3bb5ad8941556bba0fa8d03c532e535f",,,,,,,,"Disease Markers",,,,"2015",,"Scopu
The-844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in mexican population
Background. Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The-844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim of the study is to evaluate the association of-844 G>A PAI-1 polymorphism with ACS. Methods. A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS. Results. The most important risk factor in our population was hypertension, followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with ACS. The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of ACS dyslipidemic patients (OR = 1.99, P = 0.04). The A allele and AA genotype of-844 polymorphism of PAI-1 gene are risk factors for ACS. The AA genotype might be associated with the development of dyslipidemia in ACS patients. © 2015 Ilian Janet Garciá-González et al
Homocysteine, MTHFR C677T and A1298C polymorphisms, and clinical and biochemical variables in the mexican population [Homocisteína, polimorfismos MTHFR C677T, A1298C e variáveis clínico-bioquímicas em população mexicana]
The objective of the current work was to analyze the relationship of serum homocysteine (Hcy) with MTHFR C677T and A1298C polymorphisms and clinical and biochemical variables in the Mexican population. Hcy (immunoassay) levels and polymorphism (PCR/RFLP) levels were determined in 102 individuals from the general population. The 677TT genotype showed significant association with body weight (r=0.012) and the 1298CC genotype tended to be associated with BMI (r̃0.06). Serum levels of Hcy in women (51/102) were 8.33 ±1.86 μmol/L and in men (51/102) 11.64 ± 4.15 μmol/L. The Hcy was positively associated with body weight (r=0.004) and negatively with Hb and Hct (r=0.001). Higher levels of Hcy were found in smokers (r=0.009) and a tendency to hyperhomocysteinemia in alcoholics and in menopausal women. There was no association of Hcy with MTHFR C677T and A1298C polymorphisms, although the analysis with dominant inheritance model for the C677T polymorphism (TT + CT vs. CC) showed a semidominant effect (r<0.10). In this study, the presence of MTHFR C677T and A1298C polymorphisms did not represent a significant risk factor for hyperhomocysteinemia; however, those differences may point out the dependence of the relative levels of Hcy modified genotypes on various environmental factors
Second female case of Myhre syndrome
Myhre syndrome is a rare disorder characterized by low birthweight, short stature, mental retardation, facial dysmorphism (blepharophimosis, midfacial hypoplasia, prognathism), heart anomalies, muscle hypertrophy, decreased joint mobility and deafness. To date 11 male cases and only one female case have been reported. This paper describes the second female case and compares the clinical and radiological findings between female and male patients. © 2004 Lippincott Williams & Wilkins
