188 research outputs found
Radiolocalisation and imaging of stably HPLAP-transfected MO4 tumours with monoclonal antibodies and fragments.
Immunotargeting of PLAP-expressing tumours was studied for two radioiodinated, highly specific anti-PLAP monoclonal antibodies, 7E8 and 17E3, differing 10-fold in affinity, as well as for 7E8 F(ab')2 fragments. An anti-CEA monoclonal antibody or anti-CD3 F(ab')2 fragments were used as controls. Specific and non-specific targeting was examined in nude mice simultaneously grafted with PLAP-positive tumours derived from MO4 1-4 cells, and CEA-positive tumours, derived from 5583-S cells. Results indicated that (1) MO4 1-4 tumours, with a stable expression of PLAP on the plasma membrane, represent a useful new in vivo model for immunodirected tumour targeting; (2) differences in antibody affinity for PLAP in vitro are not reflected in antibody avidity for tumour cells in vivo; and (3) excellent selective and specific localisation of the PLAP-positive tumours is achieved when 7E8 F(ab')2 fragments are used. The high tumour/blood ratios (10.7 +/- 3.9 at 46 h after injection) were due to a much faster blood clearance of 7E8 F(ab')2 fragments. At this time point, the mean tumour/non-tumour tissue ratio was as high as 34.5, and the mean specific localisation index was 29.0. As expected, the F(ab')2 fragments provided high tumour imaging efficiency on gamma camera recording. These data imply important potentials of the PLAP/anti-PLAP system for immunolocalisation and therapy in patients, but also emphasise that in vitro criteria alone are not reflected in in vivo tumour localisation capacities of antibodies
Landbouw
On 18 June 2007 at 1140 hrs (local time), [the Victim] a (Commercial demining group) Deminer, inadvertently caused an item of explosive ordnance (EO), which is considered to be a No. 4A anti-personnel mine, to activate, while conducting the manual mine clearance full excavation procedure. As a result of the explosion [the Victim] was thrown backwards by the blast wave and suffered a traumatic amputation of the right hand, a fractured right humerous and critical head and eye injuries
Ultralow surface recombination of c-Si substrates passivated by plasma-assisted atomic layer deposited Al2O3
First Observation of the Doubly Charmed Baryon Xi_cc^+
We observe a signal for the doubly charmed baryon Xi_cc^+ in the charged
decay mode Xi_cc^+ --> Lambda_c^+ K- pi+ in data from SELEX, the charm
hadro-production experiment at Fermilab. We observe an excess of 15.9 events
over an expected background of 6.1 +/- 0.5 events, a statistical significance
of 6.3sigma. The observed mass of this state is (3519 +/- 1) MeV/c^2. The
Gaussian mass width of this state is 3MeV/c^2, consistent with resolution; its
lifetime is less than 33fsec at 90% confidence.Comment: 5 pages, 3 figures, accepted for publication in Physical Review
Letter
First observation of a narrow charm-strange meson DsJ(2632) -> Ds eta and D0 K+
We report the first observation of a charm-strange meson DsJ(2632) at a mass
of 2632.6+/-1.6 MeV/c^2 in data from SELEX, the charm hadro-production
experiment E781 at Fermilab. This state is seen in two decay modes, Ds eta and
D0 K+. In the Ds eta decay mode we observe an excess of 49.3 events with a
significance of 7.2sigma at a mass of 2635.9+/-2.9 MeV/c^2. There is a
corresponding peak of 14 events with a significance of 5.3sigma at 2631.5+/-1.9
MeV/c^2 in the decay mode D0 K+. The decay width of this state is <17 MeV/c^2
at 90% confidence level. The relative branching ratio Gamma(D0K+)/Gamma(Dseta)
is 0.16+/-0.06. The mechanism which keeps this state narrow is unclear. Its
decay pattern is also unusual, being dominated by the Ds eta decay mode.Comment: 5 pages, 3 included eps figures. v2 as accepted for publication by
PR
First Measurement of pi e -> pi e gamma Pion Virtual Compton Scattering
Pion Virtual Compton Scattering (VCS) via the reaction pi e --> pi e gamma
was observed in the Fermilab E781 SELEX experiment. SELEX used a 600 GeV/c pi-
beam incident on target atomic electrons, detecting the incident pi- and the
final state pi-, electron and gamma. Theoretical predictions based on chiral
perturbation theory are incorporated into a Monte Carlo simulation of the
experiment and are compared to the data. The number of reconstructed events (9)
and their distribution with respect to the kinematic variables (for the
kinematic region studied) are in reasonable accord with the predictions. The
corresponding pi- VCS experimental cross section is sigma=38.8+-13 nb, in
agreement with the theoretical expectation sigma=34.7 nb.Comment: 10 pages, 12 figures, 4 tables, 25 references, SELEX home page is
http://fn781a.fnal.gov/, revised July 21, 2002 in response to journal referee
Comment
Observation of the Cabibbo-suppressed decay Xi_c+ -> p K- pi+
We report the first observation of the Cabibbo-suppressed charm baryon decay
Xi_c+ -> p K- pi+. We observe 150 +- 22 events for the signal. The data were
accumulated using the SELEX spectrometer during the 1996-1997 fixed target run
at Fermilab, chiefly from a 600 GeV/c Sigma- beam. The branching fractions of
the decay relative to the Cabibbo-favored Xi_c+ -> Sigma+ K- pi+ and Xi_c+ ->
X- pi+ pi+ are measured to be B(Xi_c+ -> p K- pi+)/B(Xi_c+ -> Sigma+ K- pi+) =
0.22 +- 0.06 +- 0.03 and B(Xi_c+ -> p K- pi+)/B(Xi_c+ -> X- pi+ pi+) = 0.20 +-
0.04 +- 0.02, respectively.Comment: 5 pages, RevTeX, 3 figures (postscript), Submitted to Phys. Rev. Let
Measurement of the Ds lifetime
We report precise measurement of the Ds meson lifetime. The data were taken
by the SELEX experiment (E781) spectrometer using 600 GeV/c Sigma-, pi- and p
beams. The measurement has been done using 918 reconstructed Ds. The lifetime
of the Ds is measured to be 472.5 +- 17.2 +- 6.6 fs, using K*(892)0K+- and phi
pi+- decay modes. The lifetime ratio of Ds to D0 is 1.145+-0.049.Comment: 5 pages, 2 figures submitted to Phys. Lett.
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