Water education grades K-6

Preface: Water Activites for Elementary Children is based upon the assumption that children learn best by doing. In education, and especilly in science, talking is not necessarily teaching. The most desireable types of learning involve direct, first hand experience, not just a teacher\u27s interpretation of these experiences. This set of learning experiences has been designed for teachers, teachers-in-training, and children, Each concept includes background information for the teacher and learning activities for the children. Lessons are designed so taht a teacher can successfully teach a unit or lession with a minimum of knowledge, preparation, and equipmnet. Most of the suggested materials are common, inexpensive items that can be easily obtained. Activities include student experiments, teacher demonstrations, reference study, and field experiences. Extension activities are designed to enrich each basic lesson. What is Water Education? Publich understanding of water, water management, and water related issues is basic to solving present and future water problems. Unfortunately, most people are only vaguely aware of the role water plays in their lives. The long term challenge is to make people water-literate, to educate citizens with respect to the problems and complexities of monitoring both ecologically and economically sound people-water ineractions. The authors assume that such understandins have simple background beginnings. For a child, these beginnings constitute playing with water. For an adult, these beginnings consist of awareness of people-water relationships in the immediate environment. Water literacy includes the following components: 1. Comprehension: An individual should know some of the facts about water, have an understanding of water-related concepts, and be able to express them in oral and/or written form. 2. Attitudes: An individual must have the ability and willingness to develop responsible and realistic attitudes based on what has been learned about water. 3. Skills: The ability and willingness to act in direct response to waht has been learned about water, to use the skills of observation, inference, classification, and problems solving in laboratory or real life situations, and to handle and use available equipment effectively. Water is a great excuse to do some fun and exciting things! The activities in this manual will help students develop a scientific attitude. Children can begin to learn cause and effect relationship, increase their natural curiosity, suspend judgment, develop a desire to search for answers, and approach problems with an open mind

Water Education ... With Emphasis on Deer Creek Reservoir - Provo River Drainage Area (Grades 5-8)

Introduction: The major goals of this publication are to: * promote an awareness of the importance of water resources associated with the target watershed; * provide teachers with learning resources which are easily used in the classroom or in the field; and * provide teachers with teaching materials which help satisfy State Core Standards

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

BACKGROUND: Mutations in the presenilin (PSEN) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter gamma-secretase activity to promote accumulation of toxic Abeta42 peptides. In this study, we compared the histopathologic and biochemical profiles of ten FAD cases expressing independent PSEN mutations and determined the degradation patterns of amyloid-beta precursor protein (AbetaPP), Notch, N-cadherin and Erb-B4 by gamma-secretase. In addition, the levels of Abeta40/42 peptides were quantified by ELISA. RESULTS: We observed a wide variation in type, number and distribution of amyloid deposits and neurofibrillary tangles. Four of the ten cases examined exhibited a substantial enrichment in the relative proportions of Abeta40 over Abeta42. The AbetaPP N-terminal and C-terminal fragments and Tau species, assessed by Western blots and scanning densitometry, also demonstrated a wide variation. The Notch-1 intracellular domain was negligible by Western blotting in seven PSEN cases. There was significant N-cadherin and Erb-B4 peptide heterogeneity among the different PSEN mutations. CONCLUSION: These observations imply that missense mutations in PSEN genes can alter a range of key gamma-secretase activities to produce an array of subtly different biochemical, neuropathological and clinical manifestations. Beyond the broad common features of dementia, plaques and tangles, the various PSEN mutations resulted in a wide heterogeneity and complexity and differed from sporadic AD.Fil: Maarouf, Chera L.. Sun Health Research Institute; Estados UnidosFil: Daugs, Ian D.. Sun Health Research Institute; Estados UnidosFil: Spina, Salvatore. Universita Degli Studi Di Siena; Italia. Indiana University; Estados UnidosFil: Vidal, Ruben. Indiana University; Estados UnidosFil: Kokjohn, Tyler A.. Sun Health Research Institute; Estados Unidos. Midwestern University; Estados UnidosFil: Patton, R. Lyle. Sun Health Research Institute; Estados UnidosFil: Kalback, Walter M.. Sun Health Research Institute; Estados UnidosFil: Luehrs, Dean C.. Sun Health Research Institute; Estados UnidosFil: Walker, Douglas G.. Sun Health Research Institute; Estados UnidosFil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Beach, Thomas G.. Sun Health Research Institute; Estados UnidosFil: Ghetti, Bernardino. Indiana University; Estados UnidosFil: Roher, Alex E.. Sun Health Research Institute; Estados Unido

Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease

Background. Epidemiological studies indicate a statistical linkage between atherosclerotic vascular disease (ATH) and Alzheimer\u27s disease (AD). Autopsy studies of cardiac disease in AD have been few and inconclusive. In this report, clinical and gross anatomic measures of cardiac disease were compared in deceased human subjects with and without AD. Methods. Clinically documented cardiovascular conditions from AD (n = 35) and elderly non-demented control subjects (n = 22) were obtained by review of medical records. Coronary artery stenosis and other gross anatomical measures, including heart weight, ventricular wall thickness, valvular circumferences, valvular calcifications and myocardial infarct number and volume were determined at autopsy. Results. Compared to non-demented age-similar control subjects, those with AD had significantly fewer total diagnosed clinical conditions (2.91 vs 4.18), decreased coronary artery stenosis (70.8 vs 74.8%), heart weight (402 vs 489 g for males; 319 vs 412 g for females) and valvular circumferences. Carriage of the Apolipoprotein E-ε4 allele did not influence the degree of coronary stenosis. Group differences in heart weight remained significant after adjustment for age, gender, body mass index and apolipoprotein E genotype while differences in coronary artery stenosis were significantly associated with body mass index alone. Conclusions. The results are in agreement with an emerging understanding that, while midlife risk factors for ATH increase the risk for the later development of AD, once dementia begins, both risk factors and manifest disease diminish, possibly due to progressive weight loss with increasing dementia as well as disease involvement of the brain\u27s vasomotor centers. © 2011 Beach et al; licensee BioMed Central Ltd