An Exploration of African American Male College Students’ Perceptions of Factors that Contribute to Their Academic Success

According to the Congressional Black Caucus Foundation (2012), college degree attainment among African American males is only 16%, as compared to 20% for African American females, and 32% for Caucasian males. A great deal of research and emphasis has been placed on the struggles, challenges and shortcomings relative to African American male educational attainment. However, more work needs to be done to determine the factors that contribute to their academic success. The purpose of this phenomenological qualitative study was to explore the factors that contributed to the academic success of African American male college students that participated in the Baldwin Wallace University Scholars program (BW Scholars). For this program, cohorts of African American male students are selected during summers before ninth grade. Those scholars receive mentoring, academic enrichment and career readiness opportunities throughout their high school years in preparation for some sort of post-secondary enrollment. The aim of the program is to give the scholars the support that they need to graduate from high school. When a scholar applies to Baldwin Wallace for undergraduate studies and is accepted, he is given a full scholarship to the university. Through one-on-one interviews, eight African American male scholars participated in this study. The results revealed their unique perceptions of academic success, and their attitudes, behaviors, and skills that were necessary for program completion. Despite their attendance in troubled urban high schools, the participants of this study benefitted from encouragement among family and friends, were careful in choosing friends, displayed good time management skills, and had a strong work ethic, all of which were important for their degree completion. Ultimately, the aim of this study is that the insights shared by the participants further inform university instructional programs that are designed to serve African American male college students

An Exploration of African American Male College Students’ Perceptions of Factors that Contribute to Their Academic Success

According to the Congressional Black Caucus Foundation (2012), college degree attainment among African American males is only 16%, as compared to 20% for African American females, and 32% for Caucasian males. A great deal of research and emphasis has been placed on the struggles, challenges and shortcomings relative to African American male educational attainment. However, more work needs to be done to determine the factors that contribute to their academic success. The purpose of this phenomenological qualitative study was to explore the factors that contributed to the academic success of African American male college students that participated in the Baldwin Wallace University Scholars program (BW Scholars). For this program, cohorts of African American male students are selected during summers before ninth grade. Those scholars receive mentoring, academic enrichment and career readiness opportunities throughout their high school years in preparation for some sort of post-secondary enrollment. The aim of the program is to give the scholars the support that they need to graduate from high school. When a scholar applies to Baldwin Wallace for undergraduate studies and is accepted, he is given a full scholarship to the university. Through one-on-one interviews, eight African American male scholars participated in this study. The results revealed their unique perceptions of academic success, and their attitudes, behaviors, and skills that were necessary for program completion. Despite their attendance in troubled urban high schools, the participants of this study benefitted from encouragement among family and friends, were careful in choosing friends, displayed good time management skills, and had a strong work ethic, all of which were important for their degree completion. Ultimately, the aim of this study is that the insights shared by the participants further inform university instructional programs that are designed to serve African American male college students

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Whole-genome sequencing of patients with rare diseases in a national health system

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. We generated WGS data for 13,037 participants, of whom 9,802 had a rare disease, and provided a genetic diagnosis to 1,138 of the 7,065 extensively phenotyped participants. We identified 95 Mendelian associations between genes and rare diseases, of which 11 have been discovered since 2015 and at least 79 are confirmed to be aetiological. By generating WGS data of UK Biobank participants2, we found that rare alleles can explain the presence of some individuals in the tails of a quantitative trait for red blood cells. Finally, we identified four novel non-coding variants that cause disease through the disruption of transcription of ARPC1B, GATA1, LRBA and MPL. Our study demonstrates a synergy by using WGS for diagnosis and aetiological discovery in routine healthcare

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort (Nature, (2020), 583, 7814, (90-95), 10.1038/s41586-020-2265-1)

An amendment to this paper has been published and can be accessed via a link at the top of the paper