1,395 research outputs found
Upping the Ante!: Physical Therapist Management of Femoral Anteversion
The purpose of this case report is to describe the outcomes following the rehabilitation of an 11-year-old female athlete with femoral anteversion utilizing Pilates based therapy in conjunction with traditional physical therapy.https://soar.usa.edu/flsaspring2017/1019/thumbnail.jp
Dysregulated NK cell PLCγ2 signaling and activity in juvenile dermatomyositis
Juvenile dermatomyositis (JDM) is a debilitating pediatric autoimmune disease manifesting with characteristic rash and muscle weakness. To delineate signaling abnormalities in JDM, mass cytometry was performed with PBMCs from treatment-naive JDM patients and controls. NK cell percentages were lower while frequencies of naive B cells and naive CD4+ T cells were higher in JDM patients than in controls. These cell frequency differences were attenuated with cessation of active disease. A large number of signaling differences were identified in treatment-naive JDM patients compared with controls. Classification models incorporating feature selection demonstrated that differences in phospholipase Cγ2 (PLCγ2) phosphorylation comprised 10 of 12 features (i.e., phosphoprotein in a specific immune cell subset) distinguishing the 2 groups. Because NK cells represented 5 of these 12 features, further studies focused on the PLCγ2 pathway in NK cells, which is responsible for stimulating calcium flux and cytotoxic granule movement. No differences were detected in upstream signaling or total PLCγ2 protein levels. Hypophosphorylation of PLCγ2 and downstream mitogen-activated protein kinase-activated protein kinase 2 were partially attenuated with cessation of active disease. PLCγ2 hypophosphorylation in treatment-naive JDM patients resulted in decreased calcium flux. The identification of dysregulation of PLCγ2 phosphorylation and decreased calcium flux in NK cells provides potential mechanistic insight into JDM pathogenesis
X-ray spectra from magnetar candidates. II Resonant cross sections for electron-photon scattering in the relativistic regime
Recent models of spectral formation in magnetars called renewed attention on
electron-photon scattering in the presence of ultra-strong magnetic fields.
Investigations presented so far mainly focussed on mildly relativistic
particles and magnetic scattering was treated in the non-relativistic (Thomson)
limit. This allows for consistent spectral calculations up to a few tens of
keVs, but becomes inadequate in modelling the hard tails (<200 keV) detected by
INTEGRAL from magnetar sources. In this paper, the second in a series devoted
to model the X-/soft gamma-ray persistent spectrum of magnetar candidates, we
present explicit, relatively simple expressions for the magnetic Compton
cross-section at resonance which account for Landau-Raman scattering up to the
second Landau level. No assumption is made on the magnetic field strength. We
find that sensible departures from the Thomson regime can bealready present at
B ~5E12 G. The form of the magnetic cross section we derived can be easily
implemented in Monte Carlo transfer codes and a direct application to magnetar
spectral calculations will be presented in a forthcoming study.Comment: 14 pages, 5 figures, accepted for publication in MNRA
Electron-Positron Jets from a Critically Magnetized Black Hole
The curved spacetime surrounding a rotating black hole dramatically alters
the structure of nearby electromagnetic fields. The Wald field which is an
asymptotically uniform magnetic field aligned with the angular momentum of the
hole provides a convenient starting point to analyze the effects of radiative
corrections on electrodynamics in curved spacetime. Since the curvature of the
spacetime is small on the scale of the electron's Compton wavelength, the tools
of quantum field theory in flat spacetime are reliable and show that a rotating
black hole immersed in a magnetic field approaching the quantum critical value
of ~G cm is unstable. Specifically, a maximally rotating
three-solar-mass black hole immersed in a magnetic field of ~G would be a copious producer of electron-positron pairs with a
luminosity of erg s.Comment: 10 pages, 6 figures, submitted to Phys. Rev.
Unstable states in QED of strong magnetic fields
We question the use of stable asymptotic scattering states in QED of strong
magnetic fields. To correctly describe excited Landau states and photons above
the pair creation threshold the asymptotic fields are chosen as generalized
Licht fields. In this way the off-shell behavior of unstable particles is
automatically taken into account, and the resonant divergences that occur in
scattering cross sections in the presence of a strong external magnetic field
are avoided. While in a limiting case the conventional electron propagator with
Breit-Wigner form is obtained, in this formalism it is also possible to
calculate -matrix elements with external unstable particles.Comment: Revtex, 7 pages. To appear in Phys. Rev. D53(2
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An Evaluation of the Potential for Creep of 3013 Inner Can Lids
This report provides the technical basis to conclude that creep induced deformation of Type 304L austenitic stainless steel can lids on inner 3013 containers will be insignificant unless the temperature of storage exceeds 400 C. This conclusion is based on experimental literature data for Types 304 and 316 stainless steel and on a phenomenological evaluation of potential creep processes
Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung
<p>Abstract</p> <p>Background</p> <p>Claudins are the main components of tight junctions, structures which are associated with cell polarity and permeability. The aim of this study was to analyze the expression of claudins 1, 3, 4, 5, and 7 in developing human lung tissues from 12 to 40 weeks of gestation.</p> <p>Methods</p> <p>47 cases were analyzed by immunohistochemisty for claudins 1, 3, 4, 5 and 7. 23 cases were also investigated by quantitative RT-PCR for claudin-1, -3 and -4.</p> <p>Results</p> <p>Claudin-1 was expressed in epithelium of bronchi and large bronchioles from week 12 onwards but it was not detected in epithelium of developing alveoli. Claudin-3, -4 and -7 were strongly expressed in bronchial epithelium from week 12 to week 40, and they were also expressed in alveoli from week 16 to week 40. Claudin-5 was expressed strongly during all periods in endothelial cells. It was expressed also in epithelium of bronchi from week 12 to week 40, and in alveoli during the canalicular period. RT-PCR analyses revealed detectable amounts of RNAs for claudins 1, 3 and 4 in all cases studied.</p> <p>Conclusion</p> <p>Claudin-1, -3, -4, -5, and -7 are expressed in developing human lung from week 12 to week 40 with distinct locations and in divergent quantities. The expression of claudin-1 was restricted to the bronchial epithelium, whereas claudin-3, -4 and -7 were positive also in alveolar epithelium as well as in the bronchial epithelium. All claudins studied are linked to the development of airways, whereas claudin-3, -4, -5 and -7, but not claudin-1, are involved in the development of acinus and the differentiation of alveolar epithelial cells.</p
Activated Magnetospheres of Magnetars
Like the solar corona, the external magnetic field of magnetars is twisted by
surface motions of the star. The twist energy is dissipated over time. We
discuss the theory of this activity and its observational status. (1) Theory
predicts that the magnetosphere tends to untwist in a peculiar way: a bundle of
electric currents (the "j-bundle") is formed with a sharp boundary, which
shrinks toward the magnetic dipole axis. Recent observations of shrinking hot
spots on magnetars are consistent with this behavior. (2) Continual discharge
fills the j-bundle with electron-positron plasma, maintaining a nonthermal
corona around the neutron star. The corona outside a few stellar radii strongly
interacts with the stellar radiation and forms a "radiatively locked" outflow
with a high e+- multiplicity. The locked plasma annihilates near the apexes of
the closed magnetic field lines. (3) New radiative-transfer simulations suggest
a simple mechanism that shapes the observed X-ray spectrum from 0.1 keV to 1
MeV: part of the thermal X-rays emitted by the neutron star are reflected from
the outer corona and then upscattered by the inner relativistic outflow in the
j-bundle, producing a beam of hard X-rays.Comment: 23 pages, 7 figures; review chapter in the proceedings of ICREA
Workshop on the High-Energy Emission from Pulsars and Their Systems, Sant
Cugat, Spain, April 201
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