Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

Acid-sensing ion channels have important functions in physiology and pathology, but the molecular composition of acid-activated chloride channels had remained unclear. We now used a genome-wide siRNA screen to molecularly identify the widely expressed acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR. ASOR is formed by TMEM206 proteins which display two transmembrane domains (TMs) and are expressed at the plasma membrane. Ion permeation-changing mutations along the length of TM2 and at the end of TM1 suggest that these segments line ASOR's pore. While not belonging to a gene family, TMEM206 has orthologs in probably all vertebrates. Currents from evolutionarily distant orthologs share activation by protons, a feature essential for ASOR's role in acid-induced cell death. TMEM206 defines a novel class of ion channels. Its identification will help to understand its physiological roles and the diverse ways by which anion-selective pores can be formed

Does competition in the housing market cause transport poverty? Interrelations of residential location choice and mobility

Abstract Introduction This contribution examines the impact of the housing market on daily mobility and is based on the assumption that, in a supply-dominated housing market, as availability and affordability decline, many people must compromise, particularly on accessibility-related decision criteria when searching for a residential location. This applies even more to households with low financial flexibility, which can neither bear the high cost of housing in accessible inner-city neighborhoods nor afford the higher cost of mobility in less well-connected suburban areas. Methods These interrelations are examined in a current study in more detail by means of problem-centered qualitative interviews highlighting the situation of low-income households, using the Munich Metropolitan Region as an example. This paper gives an overview of interrelations and presents selected results of the study. Results Low-income households do not change their residential location unless it is really necessary. If they do move, they are nearly unable to optimize their location in order to have better access to destinations. Whereas they are able to change some destinations, there are also some immutable destinations, which lead to an increase in effort spent on transport. Conclusions All in all the insights presented confirm the suggested assumptions. They show the very limited residential choices low-income households have, but leave room for further evaluations on possible implications