212 research outputs found
A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release
A novel thermoresponsive snaptop for stimulated cargo release from superparamagnetic iron oxide core - mesoporous silica shell nanoparticles based on a [2 + 4] cycloreversion reaction (retro-Diels Alder reaction) is presented. The non-invasive external actuation through alternating magnetic fields makes this material a promising candidate for future applications in externally triggered drug delivery
Resonant Transfer and Excitation in Li-Like F Colliding with Hâ‚‚
We have measured coincidences between x rays and projectiles that have captured one electron in F6+ + H2 collisions at projectile energies between 15 and 33 MeV. The cross sections for capture and simultaneous x-ray emission as a function of projectile energy show clear structures. Indications of an unexpectedly high population of high-n states predominantly formed by resonant transfer and excitation (RTE) were found. Above the Kln (n\u3e1) RTE resonance energies another maximum was observed
Comparison of exact and approximate cross-sections in relativistic Coulomb excitation
We present a new method of obtaining time-dependent matrix elements of the
electromagnetic pulse produced by a highly-relativistic projectile. These
matrix elements are used in a coupled-channel calculation to predict the
cross-sections for population of 1- and 2-phonon states of the giant dipole
resonance. Comparisons are made with the predictions of the long-wavelength and
Born approximations.Comment: 26 pages, LaTex2
Population of Highly Excited Intermediate Resonance States by Electron Transfer and Excitation
Coincidences between two sulfur K x rays were detected from collisions of hydrogenlike S ions with H2 gas in the projectile energy range between 150 and 225 MeV. These K x rays are emitted in the decay of doubly excited states formed in the collisions via transfer and excitation. The excitation function for two coincident Kβ transitions peaks at about 175 MeV, slightly above the expected KMM resonance energy for resonant transfer and excitation (RTE). This demonstrates the occurrence of ΔN≥2 transitions (i.e., KMM and higher resonances) in the RTE process. The cross sections for the population of the very highly excited states are higher than those predicted by theoretical calculations that use dielectronic recombination rates folded with the Compton profile for the bound electrons
Machine learning models predict liver steatosis but not liver fibrosis in a prospective cohort study
Introduction
Screening for liver fibrosis continues to rely on laboratory panels and non-invasive tests such as FIB-4-score and transient elastography. In this study, we evaluated the potential of machine learning (ML) methods to predict liver steatosis on abdominal ultrasound and liver fibrosis, namely the intermediate-high risk of advanced fibrosis, in individuals participating in a screening program for colorectal cancer.
Methods
We performed ultrasound on 5834 patients admitted between 2006 and 2020, and transient elastography on a subset of 1240 patients. Steatosis on ultrasound was diagnosed if liver areas showed a significantly increased echogenicity compared to the renal parenchyma. Liver fibrosis was defined as a liver stiffness measurement ≥8 kPa in transient elastography. We evaluated the performance of three algorithms, namely Extreme Gradient Boosting, Feed-Forward neural network and Logistic Regression, deriving the models using data from patients admitted from January 2007 up to January 2016 and prospectively evaluating on the data of patients admitted from January 2016 up to March 2020. We also performed a performance comparison with the standard clinical test based on Fibrosis-4 Index (FIB-4).
Results
The mean age was 58±9 years with 3036 males (52%). Modelling laboratory parameters, clinical parameters, and data on eight food types/dietary patterns, we achieved high performance in predicting liver steatosis on ultrasound with AUC of 0.87 (95% CI [0.87–0.87]), and moderate performance in predicting liver fibrosis with AUC of 0.75 (95% CI [0.74–0.75]) using XGBoost machine learning algorithm. Patient-reported variables did not significantly improve predictive performance. Gender-specific analyses showed significantly higher performance in males with AUC of 0.74 (95% CI [0.73–0.74]) in comparison to female patients with AUC of 0.66 (95% CI [0.65–0.66]) in prediction of liver fibrosis. This difference was significantly smaller in prediction of steatosis with AUC of 0.85 (95% CI [0.83–0.87]) in female patients, in comparison to male patients with AUC of 0.82 (95% CI [0.80–0.84]).
Conclusion
ML based on point-prevalence laboratory and clinical information predicts liver steatosis with high accuracy and liver fibrosis with moderate accuracy. The observed gender differences suggest the need to develop gender-specific models
Inclusive meson production in peripheral collisions of ultrarelativistic heavy ions
There exist several proposals to use Weizs\"{a}cker-Williams photons
generated by ultrarelativistic heavy ions to produce exotic particles in
fusion reactions. To estimate the background conditions for such
reactions we analyze various mechanisms of meson production in very peripheral
collisions of ultrarelativistic heavy ions at RHIC and LHC energies. Besides
fusion they include also electromagnetic interactions
and strong nucleon-nucleon interactions in grazing collisions. All these
processes are characterised by low multiplicities of produced particles.
and events are simulated by corresponding Monte Carlo codes,
RELDIS and FRITIOF. In each of these processes a certain fraction of pions is
produced close to the mid-rapidity region that gives a background for the
events. The possibility of selecting mesons produced in
fusion events via different cut procedures is
demonstrated.Comment: 27 pages with 4 eps-figures included, uses axodraw.sty Tab.2 and 3
correcte
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Study of material properties using channeling radiation
A possible application for channeling radiation is for investigating the properties of crystals in which the channeling occurs. In this paper we present some general considerations concerning channeling radiation as a measurement technique, and then we proceed to describe several specific examples
Particle emission following Coulomb excitation in ultrarelativistic heavy-ion collisions
We study nuclear reactions induced by virtual photons associated with
Lorentz-boosted Coulomb fields of ultrarelativistic heavy ions. Evaporation,
fission and multifragmentation mechanisms are included in a new RELDIS code,
which describes the deexcitation of residual nuclei formed after single and
double photon absorption in peripheral heavy-ion collisions. Partial cross
sections for different dissociation channels, including the multiple neutron
emission ones, are calculated and compared with data when available. Rapidity
and transverse momentum distributions of nucleons, nuclear fragments and pions,
produced electromagnetically, are also calculated. These results provide
important information for designing large-rapidity detectors and zero-degree
calorimeters at RHIC and LHC. The electromagnetic dissociation of nuclei
imposes some constrains on the investigation of exotic particle production in
gamma-gamma fusion reactions.Comment: 26 LaTeX pages including 8 figures, uses epsf.st
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