34 research outputs found
Spin Accumulation in Quantum Wires with Strong Rashba Spin-Orbit Coupling
We present analytical and numerical results for the effect of Rashba
spin-orbit coupling on band structure, transport, and interaction effects in
quantum wires when the spin precession length is comparable to the wire width.
In contrast to the weak-coupling case, no common spin-quantization axis can be
defined for eigenstates within a single-electron band. The situation with only
the lowest spin-split subbands occupied is particularly interesting because
electrons close to Fermi points of the same chirality can have approximately
parallel spins. We discuss consequences for spin-dependent transport and
effective Tomonaga-Luttinger descriptions of interactions in the quantum wire.Comment: 4 pages, 4 figures, expanded discussion of spin accumulatio
Effect of bulk inversion asymmetry on the Datta-Das transistor
A model of the Datta-Das spin field-effect transistor is presented which, in
addition to the Rashba interaction, takes into account the influence of bulk
inversion asymmetry of zinc-blende semiconductors. In the presence of bulk
inversion asymmetry, the conductance is found to depend significantly on the
crystallographic orientation of the channel. We determine the channel direction
optimal for the observation of the Datta-Das effect in GaAs and InAs-based
devices.Comment: 4 pages, Revtex4, 4 EPS figure
Spin-current modulation and square-wave transmission through periodically stubbed electron waveguides
Ballistic spin transport through waveguides, with symmetric or asymmetric
double stubs attached to them periodically, is studied systematically in the
presence of a weak spin-orbit coupling that makes the electrons precess. By an
appropriate choice of the waveguide length and of the stub parameters injected
spin-polarized electrons can be blocked completely and the transmission shows a
periodic and nearly square-type behavior, with values 1 and 0, with wide gaps
when only one mode is allowed to propagate in the waveguide. A similar behavior
is possible for a certain range of the stub parameters even when two-modes can
propagate in the waveguide and the conductance is doubled. Such a structure is
a good candidate for establishing a realistic spin transistor. A further
modulation of the spin current can be achieved by inserting defects in a
finite-number stub superlattice. Finite-temperature effects on the spin
conductance are also considered.Comment: 19 pages, 8 figure
Spin transport of electrons through quantum wires with spatially-modulated strength of the Rashba spin-orbit interaction
We study ballistic transport of spin-polarized electrons through quantum
wires in which the strength of the Rashba spin-orbit interaction (SOI) is
spatially modulated. Subband mixing, due to SOI, between the two lowest
subbands is taken into account. Simplified approximate expressions for the
transmission are obtained for electron energies close to the bottom of the
first subband and near the value for which anticrossing of the two lowest
subbands occurs. In structures with periodically varied SOI strength, {\it
square-wave} modulation on the spin transmission is found when only one subband
is occupied and its possible application to the spin transistor is discussed.
When two subbands are occupied the transmission is strongly affected by the
existence of SOI interfaces as well as by the subband mixing
Spin injection into a ballistic semiconductor microstructure
A theory of spin injection across a ballistic
ferromagnet-semiconductor-ferromagnet junction is developed for the Boltzmann
regime. Spin injection coefficient is suppressed by the Sharvin
resistance of the semiconductor , where is the
Fermi-surface cross-section. It competes with the diffusion resistances of the
ferromagnets , and in the absence of contact
barriers. Efficient spin injection can be ensured by contact barriers. Explicit
formulae for the junction resistance and the spin-valve effect are presented.Comment: 5 pages, 2 column REVTeX. Explicit prescription relating the results
of the ballistic and diffusive theories of spin injection is added. To this
end, some notations are changed. Three references added, typos correcte
Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines – Multi-country assessment
Background: In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess a possible association and inform policy on future use of adjuvants, we conducted a multi-country study of narcolepsy and adjuvanted pH1N1 vaccines. Methods: We used electronic health databases to conduct a dynamic retrospective cohort study to assess narcolepsy incidence rates (IR) before and during pH1N1 virus circulation, and after pH1N1 vaccination campaigns in Canada, Denmark, Spain, Sweden, Taiwan, the Netherlands, and the United Kingdom. Using a case-control study design, we evaluated the risk of narcolepsy following AS03- and MF59-adjuvanted pH1N1 vaccines in Argentina, Canada, Spain, Switzerland, Taiwan, and the Netherlands. In the Netherlands, we also conducted a case-coverage study in children born between 2004 and 2009. Results: No changes in narcolepsy IRs were observed in any periods in single study sites except Sweden and Taiwan; in Taiwan incidence increased after wild-type pH1N1 virus circulation and in Sweden (a previously identified signaling country), incidence increased after the start of pH1N1 vaccination. No association was observed for Arepanrix-AS03 or Focetria-MF59 adjuvanted pH1N1 vaccines and narcolepsy in children or adults in the case-control study nor for children born between 2004 and 2009 in the Netherlands case-coverage study for Pandemrix-AS03. Conclusions: Other than elevated narcolepsy IRs in the period after vaccination campaigns in Sweden, we did not find an association between AS03- or MF59-adjuvanted pH1N1 vaccines and narcolepsy in children or adults in the sites studied, although power to evaluate the AS03-adjuvanted Pandemrix brand vaccine was limited in our study
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility
Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls. We directly implicate ten genes in general onset CD for the first time to our knowledge via association to coding variation, four of which lie within established CD GWAS loci. In nine instances, a single coding variant is significantly associated, and in the tenth, ATG4C, we see additionally a significantly increased burden of very rare coding variants in CD cases. In addition to reiterating the central role of innate and adaptive immune cells as well as autophagy in CD pathogenesis, these newly associated genes highlight the emerging role of mesenchymal cells in the development and maintenance of intestinal inflammation.Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn's disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.Cellular mechanisms in basic and clinical gastroenterology and hepatolog
Small area estimation: new developments and directions
The purpose of this paper is to provide a critical review of the main advances in small area estimation (SAE) methods in recent years. We also discuss some of the earlier developments, which serve as a necessary background for the new studies. The review focuses on model dependent methods with special emphasis on point prediction of the target area quantities, and mean square error assessments. The new models considered are models used for discrete measurements, time series models and models that arise under informative sampling. The possible gains from modeling the correlations among small area random effects used to represent the unexplained variation of the small area target quantities are examined. For review and appraisal of the earlier methods used for SAE, see Ghosh and Rao (1994)