13 research outputs found
Circulating levels of novel adipocytokines in patients with colorectal cancer
Objective: Adipocytokines have been reported to contribute to the pathogenesis of colorectal cancer
(CRC). The aim of this matched case-control study was to explore circulating novel adipocytokines, such
as serum visfatin, omentin-1 and vaspin levels in patients with CRC.
Method: Serum visfatin, omentin-1, and vaspin levels were measured in 69 subjects (39 patients with
colorectal cancer and 30 age- and sex-matched healthy controls) using enzyme-linked immunosorbent
assay (ELISA) methods.
Results: Compared with the controls, patients with CRC had significantly higher circulating omentin-1
(203.23 vs 9.12 ng/ml, p < 0.0001) visfatin (4.03 vs 2.01 ng/ml, p < 0.0001) and vaspin (0.54 vs 0.31 ng/
ml, p = 0.015) levels. After adjustment for covariates (age and body mass index), patients with CRC had
significantly higher serum omentin-1 (p < 0.0001), visfatin (p < 0.0001), and vaspin (p = 0.040) levels than
the control group. Furthermore, the results did not change when age and waist-to-hip ratio were considered
as covariates in the general linear models.
Conclusions: The observed higher levels of omentin-1, visfatin, and vaspin in patients with CRC, independent
of measures of obesity, suggest that these adipocytokines may have a potential role in the development
of CRC through mechanisms other than the indirect mechanisms that are active in the association
between obesity and CRC
Circulating levels of novel adipocytokines in patients with colorectal cancer
Objective: Adipocytokines have been reported to contribute to the pathogenesis of colorectal cancer
(CRC). The aim of this matched case-control study was to explore circulating novel adipocytokines, such
as serum visfatin, omentin-1 and vaspin levels in patients with CRC.
Method: Serum visfatin, omentin-1, and vaspin levels were measured in 69 subjects (39 patients with
colorectal cancer and 30 age- and sex-matched healthy controls) using enzyme-linked immunosorbent
assay (ELISA) methods.
Results: Compared with the controls, patients with CRC had significantly higher circulating omentin-1
(203.23 vs 9.12 ng/ml, p < 0.0001) visfatin (4.03 vs 2.01 ng/ml, p < 0.0001) and vaspin (0.54 vs 0.31 ng/
ml, p = 0.015) levels. After adjustment for covariates (age and body mass index), patients with CRC had
significantly higher serum omentin-1 (p < 0.0001), visfatin (p < 0.0001), and vaspin (p = 0.040) levels than
the control group. Furthermore, the results did not change when age and waist-to-hip ratio were considered
as covariates in the general linear models.
Conclusions: The observed higher levels of omentin-1, visfatin, and vaspin in patients with CRC, independent
of measures of obesity, suggest that these adipocytokines may have a potential role in the development
of CRC through mechanisms other than the indirect mechanisms that are active in the association
between obesity and CRC
E-Health literacy of medical and health sciences university students in Mashhad, Iran in 2016: a pilot study
Background: In order to provide a better healthcare education to the society, health care students should have an
acceptable electronic health (E-Health) literacy.
Objective: The aim of this study was to assess the level of E-Health literacy of Medicine and Health Sciences
university students in Mashhad, Iran.
Methods: This cross-sectional study was performed on 192 students of Mashhad University of Medical Sciences
using a validated Persian translate of the E-Health literacy scale (P-EHEALS) questionnaire in 2016.
Demographic data including age, monthly income, level of education, preference of website for obtaining health
related information and minutes of Internet use per day were obtained from the subjects. Independent-samples ttest
and analysis of variance (ANOVA) were used for comparison between groups, and Pearson correlation
coefficient and linear regression were used to assess the correlation between study parameters and EHEALS
score using SPSS version 21.
Results: A total of 192 (67.2% female and 32.8% male) subjects with mean age of 24.71±5.30 years participated
in the study. Mean P-EHEALS score of the subjects was 28.21±6.95. There was a significant difference in P- EHEALS score between genders (p<0.001), department (p=0.001), education level (p<0.001) and health status
(p=0.003) as well as monthly income (p=0.03), website preference categories (p=0.02). Male students were
significantly more likely to gain higher P-EHEALS scores.
Conclusion: The level of E-Health literacy was low in Medical and Health Sciences university students in
Mashhad. More studies are needed to assess the contributors to E-Health literac
The effect of age on the outcome of esophageal cancer surgery
Background: Surgery is still the best way for treatment of esophageal cancer. The increase in life expectancy and the rising incidence of esophageal tumors have led to a great number of elderly candidates for complex surgery. The purpose of this study was to evaluate the effects of advanced age (70 years or more) on the surgical outcome of esophagectomy for esophageal cancer at a single high-volume center. Materials and Methods: Between January 2000 and April 2006, 480 cases with esophageal cancer underwent esophagectomy in the referral cancer institute. One hundred sixty-five patients in the elderly group (70 years old or more) were compared with 315 patients in the younger group (< 70 years). All in-hospital morbidity and mortality were studied. Results: The range of age was 38-84 years, with a mean of 58.7. The mean age of the elderly and younger groups was 74 and 53.2, respectively. In the younger group, 70 patients (22.2%) and in the elderly group, 39 patients (23.6%) were complicated ( P 0.72).The most common complications in the two groups were pulmonary complications (9.8% in younger and 10.3% in elderly) ( P 0.87). Rates of anastomotic leakage and cardiac complications were also similar between the two groups. Hospital mortality rates in younger and elderly patients were 2.8% and 3%, respectively. There was no significant difference between the two groups in morbidities and mortality ( P -value > 0.05). Conclusions: With increased experience and care, the outcomes of esophagectomy in elderly patients are comparable to young patients. Advanced age alone is not a contraindication for esophagectomy