37 research outputs found
Characterization of high-temperature PbTe p-n junctions prepared by thermal diffusion and by ion-implantation
We describe here the characteristics of two types of high-quality PbTe
p-n-junctions, prepared in this work: (1) by thermal diffusion of In4Te3 gas
(TDJ), and (2) by ion implantation (implanted junction, IJ) of In (In-IJ) and
Zn (Zn-IJ). The results, as presented here, demonstrate the high quality of
these PbTe diodes. Capacitance-voltage and current-voltage characteristics have
been measured. The measurements were carried out over a temperature range from
~ 10 K to ~ 180 K. The latter was the highest temperature, where the diode
still demonstrated rectifying properties. This maximum operating temperature is
higher than any of the earlier reported results.
The saturation current density, J0, in both diode types, was ~ 10^-5 A/cm2 at
80 K, while at 180 K J0 ~ 10^-1 A/cm2 in TDJ and ~ 1 A/cm2 in both
ion-implanted junctions. At 80 K the reverse current started to increase
markedly at a bias of ~ 400 mV for TDJ, and at ~550 mV for IJ. The ideality
factor n was about 1.5-2 for both diode types at 80 K. The analysis of the C-V
plots shows that the junctions in both diode types are linearly graded. The
analysis of the C-V plots allows also determining the height of the junction
barrier, the concentrations and the concentration gradient of the impurities,
and the temperature dependence of the static dielectric constant. The
zero-bias-resistance x area products (R0Ae) at 80 K are: 850 OHMcm2 for TDJ,
250 OHMcm2 for In-IJ, and ~ 80 OHMcm2 for Zn-IJ, while at 180 K R0Ae ~ 0.38
OHMcm2 for TDJ, and ~ 0.1 OHMcm2 for IJ. The estimated detectivity is: D* ~
10^10 cmHz^(1/2)/W up to T=140 K, determined mainly by background radiation,
while at T=180 K, D* decreases to 108-107 cmHz^(1/2)/W, and is determined by
the Johnson noise
Teaching Medical Students Optimal Consulting Skills: The Challenge of Generating Better Referring Physicians.
Rationale and objectives We sought to incorporate a new teaching module into the traditional medical student radiology clerkship, to improve the necessary skills for future referring physicians. Materials and methods A new required and graded module was introduced in 2014 into the radiology clerkship in year three of medical school: the Mystery Case. Each student was provided a unique and undifferentiated case from a dedicated teaching file containing de-identified images and requisition data. Students were expected to complete three serial tasks over one week: 1) prepare a voice recognition-derived, structured radiological report utilizing appropriate and relevant vocabulary; 2) discuss pertinent additional clinical information; and 3) discuss appropriate follow-up imaging, in addition to information on how to best prepare patients for these potential patient exams (e.g., with or without contrast, bowel preparation, and length of study). Students were provided written examples and dedicated class instruction with interactive discussions covering specific cases and associated related cases through random pairing with radiology resident and attending mentors. At the close of the week, students gave brief oral presentations of their cases and submitted the tasks for a written evaluation. Upon completion of the clerkship, the students completed a Likert-type six-item survey to evaluate the perceived improvement in select skills. Results The survey was completed by 82% (54/66) of the enrolled students, with 85% finding the Mystery Case an effective use of time. Medical students perceived an improved awareness of the patient care process (77%), awareness of the medical imaging resources available (89%), ability to understand a radiology report (74%), and ability to advise patients (69%). Conclusion Introduction of the Mystery Case as a graded exercise in the medical school radiology clerkship was perceived by students as effective use of time, with an improvement in the skills essential for future referring physicians
Minority carrier transport in p-ZnO nanowires
In this work, we explore the minority carrier diffusion length in zinc oxide nanowires, using the electron beam-induced current technique. Systematic measurements as a function of temperature were performed on p-type, Sb-doped ZnO film, containing a 4 mu m thick nanowire layer. The minority carrier diffusion length exhibits a thermally activated increase with the energy of 74 +/- 5 meV. Electron beam irradiation also causes the diffusion length increase with the activation energy of 247 +/- 10 meV, likely related to Sb(Zn)-2V(Zn) acceptor-complex
Polimerne mješavine obložene Eudragitom: Potencijalni sustav za kontroliranu peroralnu isporuku teofilina
Sustained release (SR) dosage forms enable prolonged and continuous deposition of the drug in the gastrointestinal (GI) tract and improve the bioavailability of medications characterized by a narrow absorption window. In this study, a new strategy is proposed for the development of SR dosage forms for theophylline (TPH). Design of the delivery system was based on a sustained release formulation, with a modified coating technique and swelling features aimed to extend the release time of the drug. Different polymers, such as Carbopol 71G (CP), sodium carboxymethylcellulose (SCMC), ethylcellulose (EC) and their combinations were tried. Prepared matrix tablets were coated with a 5 % (m/m) dispersion of Eudragit (EUD) in order to get the desired sustained release profile over a period of 24 h. Various formulations were evaluated for drug concentration and in vitro drug release. It was found that the in vitro drug release rate decreased with increasing the amount of polymer. Coating with EUD resulted in a significant lag phase in the first two hours of dissolution in the acidic pH of simulated gastric fluid (SGF) due to decreased water uptake, and hence decreased driving force for drug release. Release became faster in the alkaline pH of simulated intestinal fluid (SIF) owing to increased solubility of both the coating and matrixing agents. The optimized formulation was subjected to in vivo studies in rabbits and the pharmacokinetic parameters of developed formulations were compared with the commercial (Asmanyl®) formulation. Asmanyl® tablets showed faster absorption (tmax 4.0 h) compared to the TPH formulation, showing a tmax value of 8.0 h. The cmax and AUC values of TPH formulation were significantly (p < 0.05) higher than those for Asmanyl®, revealing relative bioavailability of about 136.93 %. Our study demonstrated the potential usefulness of eudraginated polymers for the oral delivery of the sparingly soluble drug theophylline.Pripravci za produljeno oslobađanje (SR) omogućavaju produljeno i kontinuirano oslobađanje lijeka u gastrointestinalnom (GI) traktu i poboljšavaju bioraspoloživost lijekova s uskim apsorpcijskim prozorom. U radu se predlaže nova strategija za razvoj formulacija s produljenim oslobađanjem teofilina (TPH), koja se temelji na sustavu za produljeno oslobađanje, kojem je u svrhu produljenja vremena oslobađanja modificiran način oblaganja i bubrenja. Korišteni su različiti polimeri, kao što su Carbopol 71G (CP), natrijeva karboksimetilceluloza (SCMC), etilceluloza (EC) i njihove kombinacije. Pripravljene matriks tablete obložene su 5-postotnom (m/m) disperzijom Eudragita (EUD) kako bi se postiglo produljeno oslobađanje tijekom 24 h. U pripravljenim formulacijama određena je koncentracija lijeka i in vitro oslobađanje. Rezultati pokazuju da se povećanjem udjela polimera smanjuje brzina oslobađanja in vitro. Oblaganje s EUD značajno je produljilo lag fazu tijekom prva 2 sata otapanja u kiselom pH simuliranog želučanog soka (SGF). Naime, oblaganje usporava ulazak vode i tako smanjuje pogonsku silu za oslobađanje lijeka. Zbog povećane topljivosti obložnog sloja i matriksa u lužnatom mediju, oslobađanje u simuliranoj intestinalnoj tekućini (SIF) je brže. Optimizirana formulacija ispitana je in vivo na zečevima. Farmakokinetički parametri novih formulacija uspoređivani su s komercijalnim pripravkom Asmanyl®. Asmanyl® tablete pokazuju bržu apsorpciju (tmax 4,0 h) u odnosu na TPH formulaciju (tmax 8,0 h). cmax i AUC vrijednosti TPH formulacije bile su značajno (p < 0,05) više od onih za Asmanyl®, što ukazuje na relativnu bioraspoloživost od oko 136,93 %. Stoga smatramo da su polimeri obloženi eudragitom potencijalno korisni za oralnu upotrebu teško topljivog lijeka teofilina
Antagonism of Sorafenib and Regorafenib actions by platelet factors in hepatocellular carcinoma cell lines
Studies Of Electron Trapping In Zno Semiconductor
It has been recently discovered that electron injection into Phosphorus-, Lithium-, Antimony- or Nitrogen-doped ZnO semiconductor, using electron beam from a Scanning Electron Microscope, as well as a forward bias application to the p-n junction or Schottky barrier, leads to a multiple-fold increase of minority carrier diffusion length and lifetime (1-4). It has also been demonstrated that forward biasing a ZnO-based photovoltaic detector results in a several-fold responsivity enhancement due to a longer minority carrier diffusion length in the detector\u27s p-region as a result of electron injection (5,6). The observed electron injection effects were attributed to the charging of the metastable centers associated with the above-referenced impurities. ©The Electrochemical Society
Розвиток іскрового плазмового спікання (ІПС) для отримання нанокристалічного термоелектричного матеріалу Bi0.5Sb1.5Te3 p-типу
Bismuth antimony telluride is the most commonly used commercial thermoelectric material for power generation and refrigeration over the temperature range of 200–400 K. Improving the performance of these materials is a complected balance of optimizing thermoelectric properties. Decreasing the grain size of Bi0.5Sb1.5Te3 significantly reduces the thermal conductivity due to the scattering phonons on the grain boundaries. In this work, it is shown the advances of spark plasma sintering (SPS) for the preparation of nanocrystalline p-type thermoelectrics based on Bi0.5Sb1.5Te3 at different temperatures (240, 350, 400oC). The complex study of structural and thermoelectric properties of Bi0.5Sb1.5Te3 were presented. The high dimensionless thermoelectric figure of merit ZT ~ 1 or some more over 300–400 K temperature range for nanocrystalline p-type Bi0.5Sb1.5Te3 was obtained.Телурид сурми вісмуту є найбільш часто використовуваним комерційним термоелектричним матеріалом для виробництва електроенергії та охолодження в діапазоні температур 200 - 400 К. Поліпшення експлуатаційних характеристик цих матеріалів доповнюється балансом оптимізації термоелектричних властивостей. Зменшення розміру зерен Bi0,5Sb1,5Te3 суттєво знижує теплопровідність за рахунок розсіювання фононів на границях зерен. У цій роботі показано досягнення іскрового плазмового спікання (ІПС) для отримання нанокристалічних термоелектриків р-типу на основі Bi0,5Sb1,5Te3 при різних температурах (240, 350, 400oC). Було представлено комплексне дослідження структурних та термоелектричних властивостей Bi0.5Sb1.5Te3. Отримано високе значення безрозмірної термоелектричної добротності ZT ~ 1 і навіть трохи більше в діапазоні температур 300 - 400 K для нанокристалічного Bi0,5Sb1,5Te3 p-типу провідності
Photoconductivity of PbTe:In films with variable microstructure
It is shown that the microstructure and features of formation of surface states in nanocrystalline and polycrystalline PbTe:In films most significantly affect the character of photoconductivity in the spectral range of 1–2.5 THz. We present the results of a study and comparative analysis of the character of conductivity of PbTe:In films in the temperature range from 4.2 to 300 K in a static mode and in variable electric fields with a frequency of up to 1 MHz with illumination with white light and under the effect of high-power terahertz laser pulses with a wavelength of up to 280 μm