Detecting Network Soft-failures with the Network Link Outlier Factor (NLOF)

In this paper, we describe and experimentally evaluate the performance of our Network Link Outlier Factor (NLOF) for detecting soft-failures in communication networks. The NLOF is computed using the throughput values derived from NetFlow records. The flow throughput values are clustered in two stages, outlier values are determined within each cluster, and the flow outliers are used to compute the outlier factor or score for each network link. When sampling NetFlow records across the full span of a network, NLOF enables the detection of soft-failures across the span of the network; large NLOF scores correlate well with links experiencing failure

A STUDY ON STRUCTURE OF PO-TERNARY SEMIRINGS

This paper is divided into two sections. In section 1, the notion of a PO-ternary semiring was introduced and examples are given.  Further the terms commutative PO-ternary semiring , quasi commutative PO-ternary semiring, normal PO-ternary semiring, left pseudo commutative PO-ternary semiring, lateral  pseudo commutative PO-ternary semiring, right pseudo commutative PO-ternary semiring and pseudo commutative PO-ternary semiring are introduced and characterized them.  Further the terms left singular, right singular and singular with respect to addition and left singular, right singular, lateral singular, singular with respect to ternary multiplication and two sided singular are introduced and made a study on them. In section 2, the terms; PO-ternary subsemiring, PO-ternary subsemiring of T generated by a set A, cyclic PO-ternary subsemiring and cyclic PO-ternary semiring are introduced.  It is proved that T be a PO-ternary semiring and A be a non-empty subset of T.  Then (A) = {a1a2....an-1;n ϵ N, a1,a2....an Ïµ A } is a smallest PO-ternary subsemiring of T.  Let T be a PO-ternary semiring and A be a non-empty subset of T.  <A> = the intersection of all PO-ternary subsemirings of  T containing A

REPLACEMENT OF COARSE AGGREGATE IN CONCRETE WITH WASTE CONCRETE AGGREGATE

Concrete is the most broadly utilized as development materials on the planet. Truth be told, concrete is utilized in for all intents and purposes everything and there is still no substitutes are accessible for a large number of its application. Without concrete, the network and society today couldn't exist. Subsequently, loads of analysts and designers are doing the exploration of the total sources. All these exploration as elective hotspots for the substitution of the normal totals in delivering concrete in the different future development works. In that idea we had influenced the exploration on the fine total substitution in M20 to level cement with the development and annihilation squander on Different examples like M1,M2,M3,M4 and M5. The proportion of sand supplanted to reused fine total are 100:0% as control, 80:20%, 50:50%, 20:80% and 0:100%. The venture clarifies about the properties of materials utilized in concrete, mechanical and transport properties of the soli

Skin Extracellular Matrix Breakdown Following Paclitaxel Therapy in Patients with Chemotherapy-Induced Peripheral Neuropathy.

The chemotherapeutic agent paclitaxel causes peripheral neuropathy, a dose-limiting side effect, in up to 68% of cancer patients. In this study, we investigated the impact of paclitaxel therapy on the skin of breast cancer patients with chemotherapy-induced peripheral neuropathy (CIPN), building upon previous findings in zebrafish and rodents. Comprehensive assessments, including neurological examinations and quality of life questionnaires, were conducted, followed by intraepidermal nerve fiber (IENF) density evaluations using skin punch biopsies. Additionally, RNA sequencing, immunostaining for Matrix-Metalloproteinase 13 (MMP-13), and transmission electron microscopy provided insights into molecular and ultrastructural changes in this skin. The results showed no significant difference in IENF density between the control and CIPN patients despite the presence of patient-reported CIPN symptoms. Nevertheless, the RNA sequencing and immunostaining on the skin revealed significantly upregulated MMP-13, which is known to play a key role in CIPN caused by paclitaxel therapy. Additionally, various genes involved in the regulation of the extracellular matrix, microtubules, cell cycle, and nervous system were significantly and differentially expressed. An ultrastructural examination of the skin showed changes in collagen and basement membrane structures. These findings highlight the presence of CIPN in the absence of IENF density changes and support the role of skin remodeling as a major contributor to CIPN

Topoisomerase IB: a relaxing enzyme for stressed DNA

DNA topoisomerase I enzymes relieve the torsional strain in DNA; they are essential for fundamental molecular processes such as DNA replication, transcription, recombination, and chromosome condensation; and act by cleaving and then religating DNA strands. Over the past few decades, scientists have focused on the DNA topoisomerases biological functions and established a unique role of Type I DNA topoisomerases in regulating gene expression and DNA chromosome condensation. Moreover, the human enzyme is being investigated as a target for cancer chemotherapy. The active site tyrosine is responsible for initiating two transesterification reactions to cleave and then religate the DNA backbone, allowing the release of superhelical tension. The different steps of the catalytic mechanism are affected by various inhibitors; some of them prevent the interaction between the enzyme and the DNA while others act as poisons, leading to TopI-D NA lesions, breakage of DNA, and eventually cellular death. In this review, our goal is to provide an overview of mechanism of human topoisomerase IB action together with the different types of inhibitors and their effect on the enzyme functionality