2,852 research outputs found

    Tolerability and efficacy of single dose albendazole, diethylcarbamazine citrate (DEC) or co-administration of albendazole with DEC in the clearance of Wuchereria bancrofti in asymptomatic microfilaraemic volunteers in Pondicherry, South India: a hospital-based study

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    BACKGROUND: The tolerability and efficacy of single dose albendazole (400 mg), diethylcarbamazine citrate (DEC) (6 mg/kg bodyweight) or co-administration of albendazole (400 mg) + DEC (6 mg/kg bodyweight) was studied in 54 asymptomatic Wuchereria bancrofti microfilaraemic volunteers in a double blind hospital-based clinical study. RESULTS: There was no significant difference in the overall incidence of adverse reactions between the three drug groups [42.1% (albendazole), 52.9% (DEC) and 61.1% (albendazole + DEC); P > 0.05]. The mean score of adverse reaction intensity did not differ significantly between the DEC and albendazole + DEC groups. However, the values in these two groups were significantly higher compared to that of albendazole alone [1.8 ± 3.0 (albendazole) vs. 5.6 ± 7.1 (DEC), 6.7 ± 6.6 (albendazole + DEC); P < 0.05]. By day 360 post-therapy there was no significant difference between the three drug groups in relation to the clearance of microfilaria [26.3% (albendazole), 17.6% (DEC), 27.8% (albendazole + DEC)], reduction in geometric mean parasite density [94.7% (albendazole), 89.5% (DEC), 95.4% (albendazole + DEC)] or reduction in filarial antigenaemia [83% (albendazole), 87% (DEC), 75% (albendazole + DEC)]. Furthermore, there was a significant decrease in mean geometric parasite density (P < 0.05) as well as antigenaemia optical density values (P < 0.01) between pre-therapy levels and day 360 post-therapy in all three groups. CONCLUSIONS: This study has shown that single dose albendazole (400 mg) has similar efficacy in the clearance of microfilaria as that of DEC or the co-administration of the two drugs. The results strengthen the rationale of using albendazole for mass annual single dose administration for the control of transmission of lymphatic filariasis

    Assessment of wetland ecosystem health using the pressure-state-response (PSR) model: A case study of Mursidabad District of West Bengal (India)

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    © 2020 by the authors. Wetlands are essential for protein production, water sanctification, groundwater recharge, climate purification, nutrient cycling, decreasing floods and biodiversity preservation. The Mursidabad district in West Bengal (India) is situated in the floodplain of the Ganga-Padma and Bhagirathi rivers. The region is characterized by diverse types of wetlands; however, the wetlands are getting depredated day-by-day due to hydro-ecological changes, uncontrolled human activities and rapid urbanization. This study attempted to explore the health status of the wetland ecosystem in 2013 and 2020 at the block level in the Mursidabad district, using the pressure-state-response model. Based on wetland ecosystem health values, we categorized the health conditions and identified the blocks where the health conditions are poor. A total of seven Landsat ETM+ spaceborne satellite images in 2001, 2013 and 2020 were selected as the data sources. The statistical data included the population density and urbanization increase rate, for all administrative units, and were collected from the census data of India for 2001 and 2011. We picked nine ecosystem indicators for the incorporated assessment of wetland ecosystem health. The indicators were selected considering every block in the Mursidabad district and for the computation of the wetland ecosystem health index by using the analytical hierarchy processes method. This study determined that 26.92% of the blocks fell under the sick category in 2013, but increased to 30.77% in 2020, while the percentage of blocks in the very healthy category has decreased markedly from 11.54% to 3.85%. These blocks were affected by higher human pressure, such as population density, urbanization growth rate and road density, which resulted in the degradation of wetland health. The scientific protection and restoration techniques of these wetlands should be emphasized in these areas

    Alpha 1 antitrypsin gene: A case-control study in chronic obstructive pulmonary disease

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    Alpha-1 antitrypsin (AAT) deficiency is an inherited disorder that causes low levels of, or no AAT in the blood. The most common illness in adults with AAT deficiency is lung disease during the third and fourth decades of life. Most commonly, it is associated with chronic obstructive pulmonary disease (COPD). Mutations in the protease inhibitor (PI) gene, located on chromosome 14, are associated with this genetic disorder. The Z protein is due to a single amino acid substitution of 342 glutamine lysine. Although cigarette smoking is the main environmental risk factor, only about 15% of smokers develop clinically significant disease suggesting other influences on disease expression. The study included hospital based age and sex matched 100 cases of COPD and 100 controls without COPD recruited from Christian Medical Centre, Jorhat, Assam. These cases were recruited from February 2009 to December 2009. Subjects were included in the COPD group on the basis of lung function test. DNA extraction was done by DNA extraction kit and amplification for AAT gene was done by site directed mutagenesis polymerase chain reaction (PCR) method as described by Tazellar et al. (1992). We found that smoking was the prior cause of COPD. A1AT deficiency is not prevalent in our population subset but certain other genes could be the attributable factor for COPD.Key words: Alpha 1-antitrypsin, chronic obstructive pulmonary disorder (COPD)

    TeV Scale Implications of Non Commutative Space time in Laboratory Frame with Polarized Beams

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    We analyze e+eγγe^{+}e^{-}\rightarrow \gamma\gamma, eγeγe^{-}\gamma \rightarrow e^{-}\gamma and γγe+e\gamma\gamma \rightarrow e^{+}e^{-} processes within the Seiberg-Witten expanded noncommutative scenario using polarized beams. With unpolarized beams the leading order effects of non commutativity starts from second order in non commutative(NC) parameter i.e. O(Θ2)O(\Theta^2), while with polarized beams these corrections appear at first order (O(Θ)O(\Theta)) in cross section. The corrections in Compton case can probe the magnetic component(ΘB\vec{\Theta}_B) while in Pair production and Pair annihilation probe the electric component(ΘE\vec{\Theta}_E) of NC parameter. We include the effects of earth rotation in our analysis. This study is done by investigating the effects of non commutativity on different time averaged cross section observables. The results which also depends on the position of the collider, can provide clear and distinct signatures of the model testable at the International Linear Collider(ILC).Comment: 22 pages, 19 figures, new comments and references added, few typos corrected, Published in JHE

    Lower bounds on the dilation of plane spanners

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    (I) We exhibit a set of 23 points in the plane that has dilation at least 1.43081.4308, improving the previously best lower bound of 1.41611.4161 for the worst-case dilation of plane spanners. (II) For every integer n13n\geq13, there exists an nn-element point set SS such that the degree 3 dilation of SS denoted by δ0(S,3) equals 1+3=2.7321\delta_0(S,3) \text{ equals } 1+\sqrt{3}=2.7321\ldots in the domain of plane geometric spanners. In the same domain, we show that for every integer n6n\geq6, there exists a an nn-element point set SS such that the degree 4 dilation of SS denoted by δ0(S,4) equals 1+(55)/2=2.1755\delta_0(S,4) \text{ equals } 1 + \sqrt{(5-\sqrt{5})/2}=2.1755\ldots The previous best lower bound of 1.41611.4161 holds for any degree. (III) For every integer n6n\geq6 , there exists an nn-element point set SS such that the stretch factor of the greedy triangulation of SS is at least 2.02682.0268.Comment: Revised definitions in the introduction; 23 pages, 15 figures; 2 table

    Management of a Fungal Perinephric Abscess (PNA): Dilemma Revisited

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    ABSTRACT Candida species can cause a wide variety of clinical syndromes, especially in immunocompromised and diabetic patients. Primary perirenal candidial abscess has been a rare reported entity. Here we report a rare case of primary PNA due to Candida species in an immunocompetent patient with diabetes mellitus and its minimal invasive management. Retrospective and prospective analysis of clinical, laboratory and radiological records along with continued follow up of patient was done. This patient was 48-year-old man, admitted with burning in micturition, right flank discomfort and low grade fever since 1 year. Abdominal ultrasound and computerized tomography were suggestive of a PNA of the right kidney. Candida species was isolated from sample obtained by C.T. guided needle aspiration. Culture of aspirate showed sensitivity to azoles. Systemic antifungal therapy based on culture report was started in form of oral drug. The patient responded well leading to resolution of lump and the fever. Appropriate timely treatment appears to be having a promising role in definitive therapy for renal and PNA due to Candida even in immunocompetent host with predisposing factors such as diabetes mellitus. This case highlights the fact that fungal infections should be included in the differential diagnosis of PNA in such patients

    Higher spin fermions in the BTZ black hole

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    Recently it has been shown that the wave equations of bosonic higher spin fields in the BTZ background can be solved exactly. In this work we extend this analysis to fermionic higher spin fields. We solve the wave equations for arbitrary half-integer spin fields in the BTZ black hole background and obtain exact expressions for their quasinormal modes. These quasinormal modes are shown to agree precisely with the poles of the corresponding two point function in the dual conformal field theory as predicted by the AdS/CFT correspondence. We also obtain an expression for the 1-loop determinant in terms of the quasinormal modes and show it agrees with that obtained by integrating the heat kernel found by group theoretic methods.Comment: 29 page
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