Characterization of ferrochrome slag as an embankment and pavement material

Various efforts are being made to use the industrial wastes as an alternate construction material to conserve the natural resources and effective utilization of the industrial waste to sustain the industrialization. But limited attempts have been made to characterize Indian ferrochrome slag as a construction material. In the work an effort has been made to characterize the ferrochrome slag as an embankment and pavement material. Different laboratory tests pertaining to Geotechnical and highway material characterization has been made and the results have been compared with other industrial wastes like fly ash, red mud and natural soil. An effort also has been made to use stabilize the low strength, residual soil in terms of increasing its strength and California bearing ratio values

Gathering over Meeting Nodes in Infinite Grid

The gathering over meeting nodes problem asks the robots to gather at one of the pre-defined meeting nodes. The robots are deployed on the nodes of an anonymous two-dimensional infinite grid which has a subset of nodes marked as meeting nodes. Robots are identical, autonomous, anonymous and oblivious. They operate under an asynchronous scheduler. They do not have any agreement on a global coordinate system. All the initial configurations for which the problem is deterministically unsolvable have been characterized. A deterministic distributed algorithm has been proposed to solve the problem for the remaining configurations. The efficiency of the proposed algorithm is studied in terms of the number of moves required for gathering. A lower bound concerning the total number of moves required to solve the gathering problem has been derived

A comprehensive review of radiation shielding concrete:Properties, design, evaluation, and applications

This review paper provides a comprehensive analysis of radiation shielding concrete, covering its properties, design, evaluation, and applications. It begins with an introduction, stating the objective and scope. The paper explores radiation shielding basics, including ionizing radiation, shielding principles, and materials used for shielding. Concrete's properties relevant to shielding, radiation attenuation mechanisms, and factors affecting its efficiency are discussed. Different types of radiation shielding concrete are examined, along with their applications. The design and formulation of shielding concrete, including mix proportions, optimization techniques, and quality control, are presented. Evaluation methods and standards are discussed. Lastly, challenges, future directions, and emerging technologies are outlined. This review paper serves as a valuable resource for professionals involved in radiation shielding. The review on radiation shielding concrete highlighted its effectiveness in attenuating ionizing radiation, emphasizing material composition, density, and thickness as key design factors. Evaluation methods, such as gamma spectroscopy and Monte Carlo simulations, are discussed, demonstrating its versatile applications in nuclear facilities, healthcare, and space exploration

I. Evaluation of Detoxified Castor Meal on Rats Ii. Toxic and Hemagglutinating Activity of Ricin

Chemistr

Structural determination of virus protein U from HIV-1 by NMR in membrane environments

AbstractVirus protein U (Vpu) from HIV-1, a small membrane protein composed of a transmembrane helical domain and two α-helices in an amphipathic cytoplasmic domain, down modulates several cellular proteins, including CD4, BST-2/CD317/tetherin, NTB-A, and CCR7. The interactions of Vpu with these proteins interfere with the immune system and enhance the release of newly synthesized virus particles. It is essential to characterize the structure and dynamics of Vpu in order to understand the mechanisms of the protein–protein interactions, and potentially to discover antiviral drugs. In this article, we describe investigations of the cytoplasmic domain of Vpu as well as full-length Vpu by NMR spectroscopy. These studies are complementary to earlier analysis of the transmembrane domain of Vpu. The results suggest that the two helices in the cytoplasmic domain form a U-shape. The length of the inter-helical loop in the cytoplasmic domain and the orientation of the third helix vary with the lipid composition, which demonstrate that the C-terminal helix is relatively flexible, providing accessibility for interaction partners

Efficacy of low-energy extracorporeal shockwave therapy and a supervised clinical exercise protocol for the treatment of chronic lateral epicondylitis: A randomised controlled study

AbstractThis randomised controlled trial was designed to evaluate the efficacy of low-energy extracorporeal shockwave therapy with a supervised exercise protocol for the treatment of chronic lateral epicondylitis. Thirty patients of lateral epicondylitis were randomly placed into two groups: an experimental group (n = 15) and a control group (n = 15). The experimental group received low-energy extracorporeal shockwave therapy and supervised exercise once a week for 3 weeks, whereas the control group received a supervised exercise protocol three times a week. Both the groups were instructed to carry out a home exercise programme twice daily for 4 weeks.Outcome parameters included in this study were pain intensity, pain-free grip strength, and the Disability of Arm, Shoulder, and Hand questionnaire. Data were collected at baseline and after the end of treatment (at 4th week). There was a decline in pain, and improvements in pain-free grip strength and limb function in both groups compared with the baseline values. At the end of the treatment period, the experimental group had greater reduction in pain intensity and better improvement in limb function (p < 0.01). It can be concluded that low-energy extracorporeal shockwave therapy, when combined with regular exercise, is an effective method for reducing pain and improving upper limb function in patients with chronic lateral epicondylitis

A Scenario of COVID-19 Disease on Mental Health Among the General Age-groups

The COVID-19 (SARS-CoV-2) virus causes a respiratory disease with physical and mental health effects, ending at general morbidity and fatality from some latest coronavirus strains, at times. During the present pandemics, people stay mainly at home, contributing to some elevated stress levels. World Health Organization (WHO) contemplates that the additional steps like, quarantine and self-isolation have stimulated daily routines of peoples, leading to a rise in agitation, oppression, sleeplessness, alcohol addiction, drug-addictions and suicidal behaviors; consequently, causing increase in cases of domestic violence, even. At this stage, health service providers cannot help the poor, elderly people, children who are susceptible to pre-medical adverse conditions. This work aims to highlight the general scenario of the mental health locally in India during covid-19 pandemic. Some lifestyles, such as yoga, meditation, Ayurvedic medication, avoiding reading on corona too much and watching TV about it, while staying with the own family with the popular healthier lifestyles are recommended to alleviate stress

A Review of the Cardiac and Cardiovascular Effects of COVID-19 in Adults and Children

Symptomatic coronavirus disease 2019 (COVID-19) typically affects the respiratory system but can involve the cardiovascular system. Cardiac complications of COVID-19 can result directly from myocarditis or indirectly from numerous other mechanisms. Differentiating between primary and secondary cardiovascular involvement-our focus in this review-may help to identify the long-term effects of COVID-19 on the heart in adults and children

The Structure of the Chemokine Receptor CXCR1 in Phospholipid Bilayers and Interactions with IL-8

CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth(1-3). IL-8, released in response to inflammatory stimuli, binds to the extracellular side of CXCR1. The ligand-activated intracellular signaling pathways result in neutrophil migration to the site of inflammation(2). CXCR1 is a class-A, rhodopsin-like G-protein-coupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors(4-7). Despite its importance, its molecular mechanism is poorly understood due to the limited structural information available. Recently, structure determination of GPCRs has advanced by tailoring the receptors with stabilizing mutations, insertion of the protein T4 lysozyme and truncations of their amino acid sequences(8), as well as addition of stabilizing antibodies and small molecules(9) that facilitate crystallization in cubic phase monoolein mixtures(10). The intracellular loops of GPCRs are critical for G-protein interactions(11) and activation of CXCR1 involves both N-terminal residues and extracellular loops(2,12,13). Our previous NMR studies indicate that IL-8 binding to the N-terminal residues is mediated by the membrane, underscoring the importance of the phospholipid bilayer for physiological activity(14). Here we report the three-dimensional structure of human CXCR1 determined by NMR spectroscopy. The receptor is in liquid crystalline phospholipid bilayers, without modification of its amino acid sequence and under physiological conditions. Features important for intracellular G-protein activation and signal transduction are revealed

mRNA Coronavirus Disease 2019 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study

In this survey study of institutions across the US, marked variability in evaluation, treatment, and follow-up of adolescents 12 through 18 years of age with mRNA coronavirus disease 2019 (COVID-19) vaccine-associated myopericarditis was noted. Only one adolescent with life-threatening complications was reported, with no deaths at any of the participating institutions