HPMC Matrix Granule Formation: Selection of Suitable Granulating Fluid

Objective: The purpose of this study was to investigate and select the suitable granulating fluid for the matrix granules consisting of hydroxypropyl methylcellulose (HPMC).Method: Viscosity of the granulating fluids containing HPMC in different solvents was determined. The matrix granules obtained from mixing the granulating fluid with propranolol HCl, HPMC and lactose were assessed for bulk density, particle size distribution, flowability and friability. SEM, DSC, powder x-ray diffraction and drug dissolution studies were conducted to characterize the physical properties of the granules.Results: Type of granulating liquid affected the granule properties. The utilization of isopropyl alcohol as a granulating liquid and subsequently adding with water was a suitable system for agglomeration of powders. Good physical properties were obtained for the granule prepared by using this granulating fluid.Conclusion: Type of solvent and amount of water played an important role for physical properties of HPMC in the formation of the matrix granule due to the hydrophilicity and gel formation of this polymer. The use of isopropyl alcohol as granulating liquid and subsequently adding with water was a suitable process in producing the matrix granules consisting of HPMC.Keywords: hydroxypropyl methylcellulose, matrix granule, granulating flui

Drug release behavior of polymeric matrix filled in capsule

A single unit sustainable drug release system was developed using hydroxypropyl methylcellulose (HPMC)-based matrices filled in capsule as the drug delivery device. Release behavior of propranolol HCl from these capsules was investigated and least square fitting was performed for the dissolution data with the different mathematical expressions. Effect of diluent, polymer, pH and hydrodynamic force on the drug release from the developed systems was investigated. The utilization of HPMC as a matrix former extended the drug release longer than 8 h. HPMC viscosity grades affected the drug release, that is, increasing the amount of fillers such as lactose and dibasic calcium phosphate enhanced the drug release rate of HPMC matrices. The hydrodynamic force, type and amount of incorporated polymer apparently influenced the drug release. The physiochemical properties of polymers and interaction between HPMC and other polymers were important factors for prolongation of the drug release. The release mechanism from HPMC-based matrices in capsules was the non-Fickian transport in which the sustainable drug release of HPMC capsules could be achieved by the addition of polymeric matrix

Sustained Release of Propranolol HCl Using Matrix Granule Comprising Wax and Polymers

ABSTRACT Typically, propranolol HCl was fast release from matrix granules filled into capsule therefore the effect of the preparation technique and matrix component on the modulation of the release of propranolol HCl was performed for producing the sustainable release of this model drug. Propranolol HCl granules containing different component prepared with different techniques were tested for the drug dissolution using dissolution apparatus. The effect of dissolution medium type and rotation speed on drug release was conducted. Preparation of matrix granule by mixing propranolol HCl dispersed in melted phytowax with HPMC and xanthan gum and subsequently wetting with the granulating liquid could provide slower drug release. The mechanism of the drug release was found to be matrix diffusion control. The release of propranolol HCl from matrix granules displayed similar behavior in water, HCl buffer pH 1.2, phosphate buffer pH 6.8 and pH change. Higher rotation speed enhanced the release of drug from matrix capsule