Synthesis and characterization of oxazine bearing pyridine scaffold as potential antimicrobial agents

<p>A series of novel compounds 1-((1-(4-(2<i>H</i>-benzo[e][1,3]oxazin-3(4<i>H</i>)-yl)phenyl)ethylidene)amino)-6-((benzylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles <b>(7a–o)</b> were synthesized by a sequence of multistep reactions. IR, ¹H NMR, ¹³C NMR, and mass spectral techniques were used to confirm the structures newly synthesized compounds. Antimicrobial activity of the title compounds <b>(7a–o)</b> was studied against strains of bacteria (<i>Staphylococcus aureus</i> and <i>Streptococcus pyogenes, Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) and fungi (<i>Candida albicans, Aspergillus niger</i> and <i>Aspergillus clavatus</i>) by serial dilution method. Compounds <b>7f</b> and <b>7k</b> exhibited significant antimicrobial activity.</p