Factors Associated with Adherence to Taking Iron Tablet among Pregnant Women in Lebak, Banten

Background: Pregnant women are at high risk of iron deficiency anemia due to increased nutrient requirement during pregnancy. Iron deficiency anemia can make individuals feel tired and exhausted. Severe anemia can also lead to complications in pregnancy. For instance, it can weaken the mother’s immune system and make infections more likely. It also increases the risk of low birth weight. Adherence to taking iron tablet is a key to prevention and control of iron deficiency anemia. This study aimed to determine factors associated with iron tablet adherence in pregnant women. Subjects and Method: This was a cross-sectional study, carried out at Puskesmas (Community Health Center), Mandala, Lebak, Banten, from July to October 2017. A sample of 185 pregnant women was selected by accidental sampling. The dependent variable was adherence to take iron tablet. The independent variables were maternal knowledge, attitude, and husband support. The data were collected by questionnaire and analyzed by a multiple logistic regression. Results: Adherence to take iron tablet increased with good maternal knowledge (OR= 5.61; 95% CI= 2.47 to 12.77; p<0.001), positive attitude (OR= 5.58; 95% CI= 2.68 to 11.61; p<0.001), and strong husband’s support (OR= 5.53; 95% CI= 2.60 to 11.73; p<0.001). Conclusion: Adherence to take iron tablet increases with good maternal knowledge,positive attitude, and strong husband’s support. Keywords: adherence, iron tablet, maternal knowledge, attitude, husband support

A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS IN THE TREATMENT OF BACTERIAL VAGINOSIS

Introduction: Metronidazole is commonly used to treat bacterial vaginosis (BV) despite its various side effects and frequent cases of BV recurrences. This study aimed to compare the effectiveness of probiotic vs metronidazole for bacterial vaginosis. Methods: A meta-analysis of randomized control trials (RCTs) was performed on the studies available in PubMed, Science Direct, Web of Science, Springer Link and the Cochrane databases. The meta-analysis was based on random-effects models and included studies evaluating BV therapy in women during their reproductive age. The data were analyzed using Rev Man 5 software for the heterogeneity. Results: Thirteen studies involving 2149 subjects were included in the analysis. The results of this meta-analysis showed that probiotic has a beneficial effect on the treatment of BV compared to placebo (OR: 0.62; 95%CI= 0.40 – 0.97). In addition, probiotics can reduce the risk of BV incidence by a halftime compared to metronidazole (RR: 0.51; 95% CI= 0.20 – 1.33), Conclusion: Probiotic therapy could be used as an alternative to metronidazole therapy for bacterial vaginosis. Keywords: the meta-analysis, bacterial vaginosis, randomized controlled tria

The Effectiveness of Adding Probiotic to Antimicrobial Agents for the Treatment of Bacterial Vaginosis: a Systematic Review

Background: Common antimicrobial regimens for treating bacterial vaginosis often cause recurrence and bacterial resistance. Previous studies have reported that a combination of antimicrobial and probiotic consisting of Lactobacillus spp. Is an effective treatment for recurrent bacterial vaginosis. Lactobacillus plays an important role in vaginal health by replacing the pathogenic colonies in vagina. This study aimed to determine the effectiveness of adding probiotic to antimicrobial therapeutic for the prevention of bacterial vaginosis(BV) recurrence.Subjects and Method: A systematic review was conducted by searching the following databases: PubMed, Science Direct, Web of Science, Springer Link and the Cochrane. The review included randomized controlled trials (RCTs) conducted in primary hospitals and private clinics. The Amsel criteria and Nugent score were used for diagnosis appraisal of bacterial vaginosis. were included in this systematic review consisting of the two types of bacterial vaginosis treatment. All pooled data analyses were based on random-effects models and intention to treat (ITT). Data were analyzed using Rev Man 5 software.Results: The review included 5 RCTs involving 692 women on reproductive age underwent treatment of BV for 5 days or more.The studies showed that combination of probiotic and antimicrobial treatment reduced the risk of bacterial vaginosis recurrence a half time compared to antimicrobial treatment alone(RR= 0.49; 95% CI= 0.17 to 1.44).Conclusion: Adding probiotic to antimicrobial regimens is more effective than antimicrobial regimens alone for treating bacterial vaginosis recurrence.Keywords: probiotic, antimicrobial, bacterial vaginosis recurrence, randomized controlled trialCorrespondence: Aquartuti Tri Darmayanti. Masters Program in Public Health, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6281329380114.Indonesian Journal of Medicine (2017), 2(3): 161-168https://doi.org/10.26911/theijmed.2017.02.03.0

Factors Affecting COVID-19 Vaccination Acceptance in Pregnant Women: A Meta-Analysis

Background: Pregnant women infected with COVID-19 were more likely to develop more severe cases than those who are not pregnant. While existing international guidelines have not prioritized routine vaccination of all pregnant women due to a lack of data on safety and effectiveness, vaccination of pregnant women is still voluntary. It was essential to understand the factors that influence the acceptance of vaccination in pregnant women, which will significantly contribute to the return of society to a pre-pandemic state. This study aimed to analyze the reasons and factors that make pregnant women receive the COVID-19 vaccination. Subjects and Method: This study was a meta-analysis. Online articles from 2010 to 2020 were searched from databases, including Pubmed, MEDLINE, EMBASE, CINAHL, and Science Direct. The PICO was as follows. Population= pregnant women. Intervention= age>25 years old, higher education, better knowledge. Comparison= age<25 years old, lower education, poorer knowledge. Outcome= acceptance of vacci-nation COVID-19. Keywords "pregnant" AND "COVID-19 vaccination", "preg¬nancy" AND "vaccination and factor associated", "pregnant women" AND "acceptance and COVID-19 vaccination". The data were analyzed by RevMan 5.3 application. Results: A total of five articles were included for meta-analysis. The data showed that pregnant women having a bachelor's degree or above (OR= 2.97; 95% CI= 1.98 to 4.45; p <0.001) and being over 25 years old (OR= 2.92; 95% CI= 2.22 to 3.85; p<0.001) were associated with an increased chance of COVID-19 vaccination acceptance. Although better knowledge about vaccination was influential, it was statistically non-significant (OR= 6.42; 95% CI= 0.83 to 49.52; p= 0.070). Conclusion: The chance of COVID-19 vaccination acceptance increases with having a bachelor's degree or above and being over 25 years old in pregnant women. Keywords: vaccine, acceptance, COVID-19, pregnant women Correspondence: Catur Setyorini. Universitas ‘Aisyiyah Yogyakarta. Jl. Siliwangi Jl. West Ringroad 63, Yogyakarta. Email: [email protected]. Mobile: 081229895846