175 research outputs found
Anticancer effect of a novel palladium-saccharinate complex of terpyridine by inducing apoptosis on ehrlich ascites carcinoma (EAC) in balb-C mice
Background/Aim: [Pd(sac)(terpy)](sac)•4H2O (sac=saccharinate and terpy=2,2′:6′,2-terpyridine) is newlysynthesized palladium(II) (Pd) complex. We investigated the antiproliferative and apoptotic effects of this complex on Ehrlich ascites carcinoma (EAC). Materials and Methods: EAC cells were administered to 33 Balb/c mice. Mice were divided randomly into four groups: control, cisplatin, Pd(II) complex and paclitaxel. Control group animals received 0.9% NaCl; other groups received treatments cisplatin, Pd(II) complex and paclitaxel on days 7 and 12. At day 14, animals were sacrificed. Expression of active caspase-3, p53 and proliferating cell nuclear antigen (PCNA) was investigated and apoptosis was evaluated by terminal deoxynucleotidyltransferase (TdT)-mediated nick-end labelling (TUNEL) technique. Results: Expression of p53 and PCNA were found to be decreased (p<0.0001), cells with active caspase-3 and TUNEL-positive cells were found to be increased (p<0.0001) in all treatment groups. Conclusion: Like cisplatin and paclitaxel, this Pd(II) complex has a strong anticancer activity against EAC by inducing apoptosis and suppressing proliferation in vivo.Istanbul University (UDP-47082
Farklı Tiroxin Dozları Uygulanan Rana ridibunda (Anura amphibia)’nın Gastrointestinal Kanalındaki Somatostatin Hücrelerinin İmmünohistokimyasal Olarak Araştırılması.
A study on the secretory function of thyroid gland in TRH stimulated (Triturus cristatus; Urodela-amphibia).
Effects of Cimetidine and Ranitidine on Liver and Various Blood Parameters of Mus musculus albinus.
Anura Amfibilerde Hipotalamus, Hipofiz Bezi ve Tiroid Bezi Arasındaki Fonksiyonel İlişkiler’’
TRH ile uyarılmış Triturus cristatus (Urodela-amphibia) tiroid bezinin salgılama fonksiyonuna ait bir çalışma
Eksojen TRH’un Triturus cristatus (Urodela-Amphibia)’da hipofiz bezi TSH hücreleri üzerine olan etkileri
The effets of exogenous thyrotrophin-releasing hormone (TRH) on the hypophysis gland TSH cells of Triturus cristatus
- …