Di-μ-methanolato-κ4 O:O-bis[tri­chlorido(dimethyl­formamide-κO)tin(IV)]

The title compound, [Sn2(CH3O)2Cl6(C3H7NO)2], contains two hexa­coordinated SnIV atoms symmetrically bridged by two deprotonated methanol ligands, with an inversion center in the middle of the planar Sn2O2 ring. The other sites of the distorted octa­hedral coordination geometry of the SnIV atom are occupied by three Cl atoms and one O atom from a dimethyl­formamide mol­ecule. The complex mol­ecules are connected by weak C—H⋯Cl hydrogen bonds into a two-dimensional supra­molecular network parallel to (10)

Dimethyl­bis(3-methylsulfanyl-1,2,4-thia­diazole-5-thiol­ato)tin(IV)

In the title compound, [Sn(CH3)2(C3H3N2S3)2], the SnIV atom is coordinated within a C2N2S2 donor set that defines a skew-trapezoidal bipyramidal geometry in which the methyl groups lie over the weakly coordinated N atoms. Two independent mol­ecules comprise the asymmetric unit, each of which lies on a mirror plane that passes through the C2Sn unit

(E)-1-[4-(Dimethyl­amino)benzyl­idene]thio­semicarbazide

In the title mol­ecule, C10H14N4S, the thio­rea plane and benzene ring form a dihedral angle of 16.0 (3) Å. In the crystal structure, inter­molecular N—H⋯S hydrogen bonds link the mol­ecules into ribbons extended in the [100] direction; these incorporate inversion dimers

Oxido{N-[(2-oxido-1-naphthyl-κO)methyl­idene]asparaginato-κ2 O 1,N 2}(1,10-phenanthroline-κ2 N,N′)vanadium(IV) N,N-dimethyl­formamide monosolvate

The tridentate Schiff base ligand of the title complex, [V(C15H12N2O4)O(C12H8N2)]·C3H7NO, was derived from the condensation of 2-hy­droxy-1-naphthaldehyde and l-asparagine. The central VIV atom is six-coordinated by one oxide O atom, two N atoms from 1,10-phenanthroline and one N atom and two O atoms from the Schiff base ligand in a distorted octa­hedral geometry. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds connect mol­ecules into centrosymmetric dimers. The C atoms of the dimethyl­formamide solvent mol­ecule are disordered over two sites with site-occupancy factors of 0.732 (13) and 0.268 (13)

{4′-[4-(4,4′-Bipyridin-1-ylmeth­yl)phen­yl]-2,2′:6′,2′′-terpyridine}chloridoplatinum(II) bis­(perchlorate) acetonitrile disolvate sesquihydrate

The asymmetric unit of the title compound, [PtCl(C32H24N5)](ClO4)2·2CH3CN·1.5H2O, comprises two unique PtII complex cations, four perchlorate anions, four acetonitrile solvent mol­ecules and three water mol­ecules. The Pt atom is four-coordinated by a tridentate chelating 2,2′:6′,2′′-terpyridine ligand and a chloride ion in a square-planar geometry with modest distortion imposed by the constraint of the terpyridyl ligand. The r.m.s. deviations from the plane comprising the four ligand donor atoms and the Pt atom are 0.0381 and 0.0472 Å in the two complex cations

Time trend analysis of thyroid cancer surgery in China: single institutional database analysis of 15,000 patients

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Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis

© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Xu, X., Li, G., Li, C., Zhang, J., Wang, Q., Simmons, D. K., Chen, X., Wijesena, N., Zhu, W., Wang, Z., Wang, Z., Ju, B., Ci, W., Lu, X., Yu, D., Wang, Q., Aluru, N., Oliveri, P., Zhang, Y. E., Martindale, M. Q., & Liu, J. Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. National Science Review, 6(5), (2019):993-1003, doi:10.1093/nsr/nwz064.Major evolutionary transitions are enigmas, and the most notable enigma is between invertebrates and vertebrates, with numerous spectacular innovations. To search for the molecular connections involved, we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans. We focused on gametes and early embryos, where the methylomes are known to evolve divergently between fish and mammals. Here, we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects, but clearly presents in deuterostomes such as echinoderms and invertebrate chordates, and then becomes more evident in vertebrates. Functional association analysis suggests that DNA methylation reprogramming is associated with development, reproduction and adaptive immunity for vertebrates, but not for invertebrates. Interestingly, the single HOX cluster of invertebrates maintains unmethylated status in all stages examined. In contrast, the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis. Notably, the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals. Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution, especially after the evolutionary transitions from invertebrates to vertebrates, and then to mammals.This work was supported by the National Key Research and Development Program of China (2018YFC1003303), the Strategic Priority Research Program of the CAS (XDB13040200), the National Natural Science Foundation of China (91519306, 31425015), the Youth Innovation Promotion Association of the CAS and the Key Research Program of Frontier Sciences, CAS (QYZDY-SSW-SMC016)

Surgical resection of recurrent differentiated thyroid cancer: patterns, detection, staging, and treatment of 683 patients

BackgroundDespite improvements in overall survival, the recurrence of differentiated thyroid cancer (DTC) is becoming more common and remains a challenge necessitating accurate reappraisal of the patient. This study aimed to describe the characteristics, reasons, morbidity, and strategies of second operations for DTC.MethodsThis was a retrospective observational study of patients with DTC who underwent a second surgery between June 2008 and June 2021 in the Department of Thyroid Surgery at China–Japanese Union Hospital, Jilin University, P.R. China. All clinical characteristics were recorded, and the analysis was estimated using SPSS.ResultsSecond surgeries were detected in 683 patients. The proportion of second operations changed with the update of international guidelines from 2015 (P < 0.001). The true recurrence rate progressively increased from 21.3% to 61.5%. The rate of an “absence of preoperative FNA” or an “absence of intraoperative pathology at first surgery” decreased from 49.8% to 12.7%, while that of a “misdiagnosis of preoperative FNA at second surgery” decreased from 10% to 1.8%. The most common tumor location during the second surgery was the lateral lymph nodes (n = 104, 36.5%), with a median time to relapse of 36 months. Completion of thyroidectomy and lymph node dissection correlated with the second operation.ConclusionAfter 2015, second surgeries were more standardized, the incidence of complications decreased, and real recurrence became the most common reason for a second DTC surgery