Prospective Associations of Actual and Perceived Descriptive Norms with Drinking Among Emerging Adults

<p><i>Background</i>: Descriptive norms are commonly associated with participant drinking. However, study participants may incorrectly perceive that their peers drink about the same amount as they do, which would bias estimates of drinking homogeneity. <i>Objectives</i>: This research examined the magnitude of associations between emerging adults' reports of their own drinking and peer drinking measured the previous year by measures of (1) participants' perceptions of friends' drinking; and (2) actual drinking reported by nominated peers. <i>Methods</i>: The data are from annual surveys conducted in 2014 and 2015, Waves 4 and 5 (the first 2 years after high school) of 7 annual assessments as part of the NEXT Generation Health Study (n = 323). Associations of participant alcohol use with perceived friend use (five closest, closest male, and closest female friends), and with actual peer use. Logistic regression analyses estimated the magnitudes of prospective associations between each measure of peer drinking at W4 and participant drinking at W5.</p

Relationship of work-family conflict, self-reported social support and job satisfaction to burnout syndrome among medical workers in southwest China: A cross-sectional study

<div><p>Background</p><p>Burnout is a psychosomatic syndrome widely observed in Chinese medical workers due to the increasing cost of medical treatment, excessive workload, and excessive prescribing behavior. No studies have evaluated the interrelationship among occupational burnout, work-family conflict, social support, and job satisfaction in medical workers. The aim of this study was to evaluate these relationships among medical workers in southwest China.</p><p>Methods</p><p>This cross-sectional study was conducted between March 2013 and December 2013, and was based on the fifth National Health Service Survey (NHSS). A total of 1382 medical workers were enrolled in the study. Pearson correlation analysis and general linear model univariate analysis were used to evaluate the relationship of work-family conflict, self-reported social support, and job satisfaction with burnout syndrome in medical workers.</p><p>Results</p><p>We observed that five dimensions of job satisfaction and self-reported social support were negatively associated with burnout syndrome, whereas three dimensions of work-family conflict showed a positive correlation. In a four-stage general linear model analysis, we found that demographic factors accounted for 5.4% of individual variance in burnout syndrome (F = 4.720, P<0.001, R² = 0.054), and that work-family conflict, self-reported social support, and job satisfaction accounted for 2.6% (F = 5.93, P<0.001, R² = 0.080), 5.7% (F = 9.532, P<0.001, R² = 0.137) and 17.8% (F = 21.608, P<0.001, R² = 0.315) of the variance, respectively. In the fourth stage of analysis, female gender and a lower technical title correlated to a higher level of burnout syndrome, and medical workers without administrative duties had more serious burnout syndrome than those with administrative duties.</p><p>Conclusions</p><p>In conclusion, the present study suggests that work-family conflict and self-reported social support slightly affect the level of burnout syndrome, and that job satisfaction is a much stronger influence on burnout syndrome in medical workers of southwest China.</p></div

Pearson correlation analysis of the relationship of work-family conflict, social support at work, and job satisfaction with burnout syndrome.

<p>Pearson correlation analysis of the relationship of work-family conflict, social support at work, and job satisfaction with burnout syndrome.</p

General linear model analysis with burnout syndrome dimensions as a dependent variable.

<p>General linear model analysis with burnout syndrome dimensions as a dependent variable.</p

Socio-demographic characteristics of investigated subjects.

<p>Socio-demographic characteristics of investigated subjects.</p

Additional file 3: of Trajectories of eating behaviors in a nationally representative cohort of U.S. adolescents during the transition to young adulthood

“Estimates (β ± SE) from linear generalized estimating equations predicting retrospective and prospective 1-year body mass index (BMI, kg/m 2 ) change,” contains results from models examining longitudinal associations of eating behaviors with change in BMI. (XLSX 12 kb

Additional file 2: of Trajectories of eating behaviors in a nationally representative cohort of U.S. adolescents during the transition to young adulthood

“Estimates (β ± SE) from linear generalized estimating equation models examining associations of eating behavior trends over time by sex and race/ethnicity,” contains results from models examining eating behavior trends by sex and race/ethnicity. (XLSX 13 kb

DataSheet_1_Treatment for a B-cell acute lymphoblastic leukemia patient carrying a rare TP53 c.C275T mutation: A case report.pdf

TP53 mutations are associated with poor prognosis in the vast majority of cancers. In this study, we present a pediatric B-cell acute lymphoblastic leukemia (B-ALL) patient carrying a rare TP53 c.C275T mutation. This extremely rare mutation affects an amino acid residue located between the TAD domain and the DNA-binding domain of p53. The patient was resistant to most conventional chemotherapy regimens and remained minimal residual disease (MRD)-positive after five rounds of such regimens. We tested the sensitivity of the patient’s leukemic cells to 21 anti-cancer drugs by performing in vitro drug sensitivity assays. The results showed that bortezomib had a very strong killing effect on the patient’s leukemic cells. Therefore, we subsequently treated the patient with bortezomib combined with vindesine, cytarabine, and fludarabine. After one course of treatment, the patient became MRD-negative, and there was no recurrence during a 9-month follow-up. In conclusion, our report suggests that the TP53 c.C275T mutation is associated with poor prognosis in B-ALL. Fortunately, bortezomib combined with chemotherapy could achieve a better therapeutic effect than conventional regimens in this type of ALL.</p