Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy

<div><p>Purpose</p><p>We investigated whether laser speckle flowgraphy (LSFG) results are comparable in both eyes and whether it is useful in the diagnosis of disparity in ocular ischemic syndrome (OIS) patients.</p><p>Methods</p><p>We compared the mean blur rate (MBR) value for various fundus regions in both eyes of 41 healthy subjects and 15 internal carotid artery occlusion (ICAO) cases. We calculated the standard value of the Laterality Index (LI), which was the MBR comparison of both eyes in each of the regions, in the control subjects. We then investigated the correlation between both eyes for the LIs in the entire fundus, the degree of ICAO and visual function.</p><p>Results</p><p>The disparity of the LIs in both eyes was least in the entire area of the fundus in control subjects and there was a significant correlation between both eyes of the 41 healthy individuals (P = 0.019). Significant correlations were found for the LI, visual acuity and degree of ICAO. The specificity and sensitivity of LI in the entire area was 93.8% and 100%, respectively.</p><p>Conclusions</p><p>LSFG revealed normal individuals have symmetrical fundus blood flow. LSFG could detect OIS and might be a useful tool for detecting disparities in fundus blood flow.</p></div

Case 1. The false color maps of a patient with ocular ischemic syndrome.

<p>Top, right eye; bottom, left eye. Although the color map of the right eye is normal, that of the left eye shows that the choroidal vasculature has disappeared and that there are faint retinal vessels present, suggesting decreased retinal and choroidal blood flows.</p

Patient MBR values for each of the comparison areas.

<p>Patient MBR values for each of the comparison areas.</p

Bilateral comparison of the mean blur ratios in the entire image in normal individuals.

<p>Correlation coefficient of the linear fit r = 0.8594 (P = 0.019).</p

Summary of MBR values from 41 healthy individuals.

<p>Summary of MBR values from 41 healthy individuals.</p

False color maps of bilateral Laser Speckle Flowgraphy in both eyes of a normal subject.

<p>Top, right eye; bottom, left eye. The right and left differences in the normal subjects was not significant in the blood flow.</p

Regions in which the mean blur ratio were measured.

<p>A indicates the retinal artery; B, the retinal vein; C, the temporal sector of the disc; D, the macular area; E, the peripapillary area; and F, the entire image.</p