6,538 research outputs found

    Islands of conformational stability for Filopodia

    Get PDF
    Filopodia are long, thin protrusions formed when bundles of fibers grow outwardly from a cell surface while remaining closed in a membrane tube. We study the subtle issue of the mechanical stability of such filopodia and how this depends on the deformation of the membrane that arises when the fiber bundle adopts a helical configuration. We calculate the ground state conformation of such filopodia, taking into account the steric interaction between the membrane and the enclosed semiflexible fiber bundle. For typical filopodia we find that a minimum number of fibers is required for filopodium stability. Our calculation elucidates how experimentally observed filopodia can obviate the classical Euler buckling condition and remain stable up to several tens of . We briefly discuss how experimental observation of the results obtained in this work for the helical-like deformations of enclosing membrane tubes in filopodia could possibly be observed in the acrosomal reactions of the sea cucumber Thyone, and the horseshoe crab Limulus. Any realistic future theories for filopodium stability are likely to rely on an accurate treatment of such steric effects, as analysed in this work

    Spicules and the effect of rigid rods on enclosing membrane tubes

    Full text link
    Membrane tubes (spicules) arise in cells, or artificial membranes, in the nonlinear deformation regime due to, e.g. the growth of microtubules, actin filaments or sickle hemoglobin fibers towards a membrane. We calculate the axial force exerted by the cylindrical membrane tube, and its average radius, by taking into account steric interactions between the fluctuating membrane and the enclosed rod. The force required to confine a fluctuating membrane near the surface of the enclosed rod diverges as the separation approaches zero. This results in a smooth crossover of the axial force between a square root and a linear dependence on the membrane tension as the tension increases and the tube radius shrinks. This crossover can occur at the most physiologically relevant membrane tensions. Our work may be important in (i) interpreting experiments in which axial force is related to the tube radius or membrane tension (ii) dynamical theories for biopolymer growth in narrow tubes where these fluctuation effects control the tube radius.Comment: 10 pages, 1 figur

    Preliminary Solar Sail Design and Fabrication Assessment: Spinning Sail Blade, Square Sail Sheet

    Get PDF
    Blade design aspects most affecting producibility and means of measurement and control of length, scallop, fullness and straightness requirements and tolerances were extensively considered. Alternate designs of the panel seams and edge reinforcing members are believed to offer advantages of seam integrity, producibility, reliability, cost and weight. Approaches to and requirements for highly specialized metalizing methods, processes and equipment were studied and identified. Alternate methods of sail blade fabrication and related special machinery, tooling, fixtures and trade offs were examined. A preferred and recommended approach is also described. Quality control plans, inspection procedures, flow charts and special test equipment associated with the preferred manufacturing method were analyzed and are discussed

    Scaling in the time-dependent failure of a fiber bundle with local load sharing

    Full text link
    We study the scaling behaviors of a time-dependent fiber-bundle model with local load sharing. Upon approaching the complete failure of the bundle, the breaking rate of fibers diverges according to r(t)(Tft)ξr(t)\propto (T_f-t)^{-\xi}, where TfT_f is the lifetime of the bundle, and ξ1.0\xi \approx 1.0 is a quite universal scaling exponent. The average lifetime of the bundle scales with the system size as NδN^{-\delta}, where δ\delta depends on the distribution of individual fiber as well as the breakdown rule.Comment: 5 pages, 4 eps figures; to appear in Phys. Rev.

    Bounds for the time to failure of hierarchical systems of fracture

    Full text link
    For years limited Monte Carlo simulations have led to the suspicion that the time to failure of hierarchically organized load-transfer models of fracture is non-zero for sets of infinite size. This fact could have a profound significance in engineering practice and also in geophysics. Here, we develop an exact algebraic iterative method to compute the successive time intervals for individual breaking in systems of height nn in terms of the information calculated in the previous height n1n-1. As a byproduct of this method, rigorous lower and higher bounds for the time to failure of very large systems are easily obtained. The asymptotic behavior of the resulting lower bound leads to the evidence that the above mentioned suspicion is actually true.Comment: Final version. To appear in Phys. Rev. E, Feb 199

    Probabilistic Approach to Time-Dependent Load-Transfer Models of Fracture

    Full text link
    A probabilistic method for solving time-dependent load-transfer models of fracture is developed. It is applicable to any rule of load redistribution, i.e, local, hierarchical, etc. In the new method, the fluctuations are generated during the breaking process (annealed randomness) while in the usual method, the random lifetimes are fixed at the beginning (quenched disorder). Both approaches are equivalent.Comment: 13 pages, 4 figures. To appear in Phys.Rev.
    corecore