104 research outputs found
Localizzazione inusuale di cisti del dotto tireoglosso
nglish version
Summary: An unusual localization of thyroglossal duct cyst.
M. Barbaro, A. Di Mario, D. De Seta, G. Rispoli, E. Covelli, G.A. Bertoli, A. Minni
Thyroglossal duct cysts are most common neck masses after benign lymphonodes. They originate from primitive thiroglossal duct, so they could be locate along its course. Every mass in the middle line of the neck can be considerated as a thyroglossal cyst. Best treatment is surgery (Sistrunk procedure).
We present a case of unusual localization at floor of the mouth of thyroglossal in a 34 years old woman. To our knowledge in literature, only two cases, have been reported both
Brown Tumour in a Patient with Secondary Hyperparathyroidism Resistant to Medical Therapy: Case Report on Successful Treatment after Subtotal Parathyroidectomy
Brown tumour represents a serious complication of hyperparathyroidism.
Differential diagnosis, based on histological examination, is only presumptive and clinical, radiological and laboratory data are necessary for definitive diagnosis. Here we describe a case of a brown tumour localised in the maxilla due to secondary hyperparathyroidism in a young women with chronic renal failure. Hemodialysis and pharmacological treatment were unsuccessful in controlling secondary hyperparathyroidism making it necessary to proceed with a subtotal parathyroidectomy. The proper timing of the parathyroidectomy and its favourable effect on regression of the brown tumor made it possible to avoid a potentially disfiguring surgical removal of the brown tumor
Clinical and organizational evidence of the efficacy and effectiveness from cardiac rehabilitation: an update
The increasing evidence on the favourable cost/effectiveness impact of the comprehensive cardiac rehabilitation program for the treatment of a wide spectrum of cardiovascular conditions have imposed to healthcare services a major attention on a critical analysis of the results in different clinical indications and delivery organisations. The Regional Health Agency of Liguria, in the occasion of drawing up regional guidelines directed to define the clinical indications and the effectiveness of the cardiac rehabilitation delivery model (in-patients, out-patients and home-based) and its requisites, indications and procedures, has updated the reference guidelines (PLNG and SIGN) with the evidence provided by the more recent literature, focusing its attention on the clinical and, in particular, organizational effectiveness. The document, on the base of these evidences, provides some effective proposals and some organizational advices
Case Report Brown Tumour in a Patient with Secondary Hyperparathyroidism Resistant to Medical Therapy: Case Report on Successful Treatment after Subtotal Parathyroidectomy
Brown tumour represents a serious complication of hyperparathyroidism. Differential diagnosis, based on histological examination, is only presumptive and clinical, radiological and laboratory data are necessary for definitive diagnosis. Here we describe a case of a brown tumour localised in the maxilla due to secondary hyperparathyroidism in a young women with chronic renal failure. Hemodialysis and pharmacological treatment were unsuccessful in controlling secondary hyperparathyroidism making it necessary to proceed with a subtotal parathyroidectomy. The proper timing of the parathyroidectomy and its favourable effect on regression of the brown tumor made it possible to avoid a potentially disfiguring surgical removal of the brown tumor
Impact of depression on circulating endothelial progenitor cells in patients with acute coronary syndromes
Aims: Depression has been identified as a risk factor for an
adverse prognosis and reduced survival in patients with
acute coronary syndrome (ACS). The number of endothelial
progenitor cells (EPCs) is an independent predictor of
clinical outcomes in patients with ACS. The aim was to
evaluate the impact of depression on EPC levels in patients
with ACS.
Methods: Out of 74 ACS patients [23 non-ST-segment
elevation myocardial infarction (NSTEMI), 48 STEMI], 36 had
a diagnosis of major depressive episode (MDE) according
to Diagnostic and Statistical Manual of Mental Disorders 4th
edition (DSM-IV) criteria at the time of the inclusion in the
study. Control groups were as follows: 15 healthy
individuals and 18 patients with current MDE without a
history of cardiovascular diseases. EPCs were defined as
CD34RCD133RKDRR and evaluated by flow cytometry. All
patients underwent standardized cardiological and
psychopathological evaluations. Parametric and
nonparametric statistical tests were performed wherever
appropriate.
Results: ACS patients with MDE showed a significant
decrease in circulating EPC number compared with ACS
patients without MDE (P <0.001). The ACS study population
was then subdivided into STEMI and NSTEMI groups, and
inside each group again patients with MDE showed a
significant decrease in circulating CD34RCD133RKDRR
EPCs compared with others (P <0.001).
Conclusion: We showed that ACS patients with MDE
have a reduced number of circulating CD34RCD133RKDRR
cells compared with ACS patients without MDE, suggesting
that the presence of MDE reduces the response of bone
marrow to acute ischemic events. Considering the
reparative role of EPCs in ACS patients, we suppose that
patients with MDE might be protected less than patients
without MDE
Evaluation of virological response and resistance profile in HIV-1 infected patients starting a first-line integrase inhibitor-based regimen in clinical settings
Background: Virological response and resistance profile were evaluated in drug-naĂŻve patients starting their first-line integrase inhibitors (INIs)-based regimen in a clinical setting. Study design: Virological success (VS) and virological rebound (VR) after therapy start were assessed by survival analyses. Drug-resistance was evaluated at baseline and at virological failure. Results: Among 798 patients analysed, 38.6 %, 27.1 % and 34.3 % received raltegravir, elvitegravir and dolutegravir, respectively. Baseline resistance to NRTIs, NNRTIs, PIs and INIs was: 3.9 %, 13.9 %, 1.6 % and 0.5 %, respectively. Overall, by 12 months of treatment, the probability of VS was 95 %, while the probability of VR by 36 months after VS was 13.1 %. No significant differences in the virological response were found according to the INI used. The higher pre-therapy viremia strata was (<100,000 vs. 100,000-500,000 vs. > 500,000 copies/mL), lower was the probability of VS (96.0 % vs. 95.2 % vs. 91.1 %, respectively, P < 0.001), and higher the probability of VR (10.2 % vs. 15.8 % vs. 16.6 %, respectively, P = 0.010). CD4 cell count <200 cell/mm3 was associated with the lowest probability of VS (91.5 %, P < 0.001) and the highest probability of VR (20.7 %, P = 0.008) compared to higher CD4 levels. Multivariable Cox-regression confirmed the negative role of high pre-therapy viremia and low CD4 cell count on VS, but not on VR. Forty-three (5.3 %) patients experienced VF (raltegravir: 30; elvitegravir: 9; dolutegravir: 4). Patients failing dolutegravir did not harbor any resistance mutation either in integrase or reverse transcriptase. Conclusions: Our findings confirm that patients receiving an INI-based first-line regimen achieve and maintain very high rates of VS in clinical practice
HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors
Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs)
Fitness for Entering a Simple Exercise Program and Mortality: A Study Corollary to the Exercise Introduction to Enhance Performance in Dialysis (Excite) Trial
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