radiobox.at: Audioproduktion im Unterricht

Im Rahmen des Forschungsprojektes „Fopa“ wurde die Verwendung von Audioproduktionen als Podcast und Radiosendungen im Unterricht an Schulen in Österreich empirisch erhoben und eine unterrichtsanalytisch fundierte und damit systematisierte Übersicht über die erhobenene unterrichtsmethodische Praxis erarbeitet.© 2015 by new academic pres

Begeisterung ist die Voraussetzung.: Eine Analyse qualitativer Interviews mit Lehrenden zur praktischen Audioproduktion im Unterricht an österreichischen Schulen aus Sicht des medialen Habitus.

Im Zeitraum von März bis Juni 2014 wurden im Rahmen des Forschungsprojektes "Audioproduktion als Lernform" qualitative Interviews mit LehrerInnen durchgeführt, die mit Audioproduktionen im Unterricht gearbeitet haben. Die Ergebnisse zeigen, dass die Audioproduktion als mediendidaktische Unterrichtsmethode in vielen Schultypen und Fächern erfolgreich verwendet wird. Der Einsatz wird entweder durch Lehrpläne oder persönliche Präferenzen der Lehrenden motiviert, die als Ausdruck des medialen Habitus verstanden werden können.As part of the research project "Audio Production as a Teaching Method" qualitative interviews with experienced teachers have been conducted between March and June 2014. Results show, that audio production as a teaching method is used in different school types and school subjects. The actual use is motivated by curricula or personal preferences of the teachers. It is suggested to interpret the personal preferences as an expression of the media Habitus

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Human serum albumin in the presence of AGuIX nanoagents: Structure stabilisation without direct interaction

International audienceThe gadolinium-based nanoagent named AGuIX ® is a unique radiosensitizer and contrast agent which improves the performance of radiotherapy and medical imaging. Currently tested in clinical trials, AGuIX ® is administrated to patients via intravenous injection. The presence of nanoparticles in the blood stream may induce harmful effects due to undesired interactions with blood components. Thus, there is an emerging need to understand the impact of these nanoagents when meeting blood proteins. In this work, the influence of nanoagents on the structure and stability of the most abundant blood protein, human serum albumin, is presented. Synchrotron radiation circular dichroism showed that AGuIX ® does not bind to the protein, even at the high ratio of 45 nanoparticles per protein at 3 mg/L. However, it increases the stability of the albumin. Isothermal thermodynamic calorimetry and fluorescence emission spectroscopy demonstrated that the effect is due to preferential hydration processes. Thus, this study confirms that intravenous injection of AGuIX ® presents limited risks of perturbing the blood stream. In a wider view, the methodology developed in this work may be applied to rapidly evaluate the impact and risk of other nano-products that could come into contact with the bloodstream

Platinum Nanoparticles Stabilize Human Serum Albumin Structure

International audienceNoble metals, especially platinum nanoparticles (Pt NPs) have immense potential in nanomedicine as therapeutic agents on account of their high surface area, intrinsic 2 catalytic properties, etc. However, our understanding of the interaction of nanoparticles with biological entities, especially proteins, is far behind the explosive development of nanotechnology. In this study, we measure the structural and stability changes of proteins at nanomolar concentrations upon interaction with Pt NPs using various techniques. A large increase of 18°C in the thermal unfolding of human serum albumin (HSA) with Pt NPs at the molar ratio 1:1 is observed using synchrotron radiation circular dichroism (SRCD), due to Pt NPs increased thermal stability of HSA through preferential hydration processes. The use of SRCD allows measuring critical parameters on NPs-protein interactions, provides additional information for understanding the influential role of PEG coating in NPs-cell interaction and has implications for nanomedicine and nanotoxicology