2 research outputs found
Developments in the Reactivity of 2‑Methylimidazolium Salts
Unexpected and unusual
reactivity of 2-methylimidazolium salts
toward aryl-<i>N</i>-sulfonylimines and aryl aldehydes is
here reported. Upon reaction with aryl-<i>N</i>-sulfonylimines,
the addition product, arylethyl-2-imidazolium-1-tosylamide (<b>3</b>), is formed with moderate to good yields, while upon reaction
with aldehydes, the initial addition product (<b>6</b>) observed
in NMR and HPLC–MS experimental analysis is postulated by us
as an intermediate to the final conversion to carboxylic acids. Studies
in the presence and absence of molecular oxygen allow us to conclude
that the imidazolium salts is crucial for the oxidation. A detailed
mechanistic study was carried out to provide insights regarding this
unexpected reactivity
Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan
Marine-derived polymers are environmentally friendly
and sustainable
biomaterials that have structural similarities with the main components
of the extracellular matrix. Moreover, some marine polymers have specific
bioactivity that can be transferred to the systems made of these biomolecules.
Herein, we developed antibacterial adhesive films combining two marine
polysaccharides, namely, fucoidan and chitosan. Fucoidan was functionalized
with catechol groups (FCat) to improve its adhesive properties. This
modification enhanced also the fucoidan antibacterial properties:
while fucoidan is active against Gram-positive bacteria, FCat showed
bactericidal activity against Gram-positive and Gram-negative bacteria.
To improve the processability and mechanical properties, FCat was
blended with chitosan and solvent-casted to obtain films. These films
exhibited an adhesion strength similar to the one of clinically used
natural adhesives and no cytotoxicity: fibroblastic cells attached
and remained viable on the films. Altogether our results demonstrated
that the developed antibacterial and adhesive films are a feasible
alternative of cytotoxic synthetic adhesives used for soft tissue
healing applications