Developments in the Reactivity of 2‑Methylimidazolium Salts

Unexpected and unusual reactivity of 2-methylimidazolium salts toward aryl-<i>N</i>-sulfonylimines and aryl aldehydes is here reported. Upon reaction with aryl-<i>N</i>-sulfonylimines, the addition product, arylethyl-2-imidazolium-1-tosylamide (<b>3</b>), is formed with moderate to good yields, while upon reaction with aldehydes, the initial addition product (<b>6</b>) observed in NMR and HPLC–MS experimental analysis is postulated by us as an intermediate to the final conversion to carboxylic acids. Studies in the presence and absence of molecular oxygen allow us to conclude that the imidazolium salts is crucial for the oxidation. A detailed mechanistic study was carried out to provide insights regarding this unexpected reactivity

Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan

Marine-derived polymers are environmentally friendly and sustainable biomaterials that have structural similarities with the main components of the extracellular matrix. Moreover, some marine polymers have specific bioactivity that can be transferred to the systems made of these biomolecules. Herein, we developed antibacterial adhesive films combining two marine polysaccharides, namely, fucoidan and chitosan. Fucoidan was functionalized with catechol groups (FCat) to improve its adhesive properties. This modification enhanced also the fucoidan antibacterial properties: while fucoidan is active against Gram-positive bacteria, FCat showed bactericidal activity against Gram-positive and Gram-negative bacteria. To improve the processability and mechanical properties, FCat was blended with chitosan and solvent-casted to obtain films. These films exhibited an adhesion strength similar to the one of clinically used natural adhesives and no cytotoxicity: fibroblastic cells attached and remained viable on the films. Altogether our results demonstrated that the developed antibacterial and adhesive films are a feasible alternative of cytotoxic synthetic adhesives used for soft tissue healing applications