Stores Instead of factories. From Deindustrialization to Modern Trade - Statistical Analysis of Suceava

Abstract The role of industrialization was to turn Romania from a rather agrarian country into a country with an industrial profile. We can say that the communist period was marked by forced industrialization, which had even created an industrial tradition that characterized the centralized economy of the country. The Romanian retail is currently characterized by an accelerated development, which leads to increased competitiveness, crystallization of modern trade forms, consolidation of modern retail networks and, last but not least, the attainment of attractive profit rates. Today, after the period of the communist regime, characterized by strong industrialization, Suceava has become a powerful trade center. Many malls are located in the place of former factories, which have been left behind or moved out of urban centers. Romanians are doing shopping in over 60 malls today. Most of the modern retail spaces, about 75% of the total, are grouped in Bucharest, Cluj-Napoca, Timisoara, Iasi, Constanta, Craiova and Brasov. In a short time, the area of modern retail space per thousand people became the largest in the country. The paper presents and analyses the transition of Suceava, from a commercial dimension perpetuated since the medieval times until the late nineteenth - early twentieth century to an industrial dimension started, timidly, in the early twentieth century and continued into an advanced form after the Second World War, during the communist regime. The paper also presents the return to a commercial dimension, after the communist regime

THE STATISTICAL DISPARITIES IN EDUCATIONAL AND DEVELOPMENT STRUCTURES IN TERRITORIAL PROFILE IN ROMANIA

Regional disparities in labor productivity basically explain regions` divergent development path. Education and specialization of labor force are key factors, which are nowadays changing rapidly and have an impact on development. Improved education is usually regarded as a source of productivity increase. The specialization of regions in traditional activities, such as subsistence agriculture, keeps a higher employment rate, but low productivity. During the empirical analysis, we used a series of regression and correlation methods, econometric tests to highlight the link, degree of intensity, and the relationship between education and growth through the use of the Pearson correlation coefficient. Territorial analysis of the employment of less educated people compresses important issues regarding territorial disparities in economic welfare. In particular, the analysis of education in Romania comprises two aspects (in the territorial and European regional context), each of which is structured according to the indicators survey: education level, gross domestic product, adult participation in lifelong learning, employment and the salary level based on information from the Population and Housing Census by making statistical correlations and interpretations

COMPARATIVE ANALYSIS OF THE GEOGRAPHICAL DISPARITIES REGARDING THE LEVEL OF EDUCATION OF THE POPULATION AND THE LEVEL OF ECONOMIC DEVELOPMENT IN ROMANIA AND IN THE REGIONAL PROFILE

Throughout this paper we undertook a research which goal is presented by the title, namely to elaborate a comparative analysis of the geographical disparities regarding the level of education of the population and the level of economic development in Romania and in the regional profile. Within the first sections of the paper we present the general coordinates of the framework components: regional economic and education level disparities. The problem of regional disparities has managed to become the most important economic policy in different regions of the EU, in the last two decades. Carrying out these general analyses of the territories in this geographical zone began, especially, after Greece, Spain, Portugal and then Romania joined the EU, states marked by significant regional imbalances, characterized by a low level of development in comparison with the other countries of the EU. Because in the developed countries, the structure of the economy is considered to be a basic condition, which must be taken into account in the process of economic development, we used these variables in order to evaluate the level of regional development and to understand the differences regarding the development between regions. The third section of the paper is presenting the comparative analyses of disparities regarding education in regional context in Romania. The analysis at the regional level of the employment of less educated people compresses important aspects  regarding the regional discrepancies in the economic welfare. Concretely, the analysis of the education in Romania comprises aspects, on the regional plan on the basis of the most representative indicators: the level of education of the population, the participation of adult population in lifelong learning, and the Gross Domestic Product per inhabitant, on a time horizon of 14 years, 2000-2014, by achieving correlations and statistical interpretations. The conclusions reflect that there are very big differences between the Bucharest-Ilfov region and the other regions of the country. Also the final ideas of the paper point out the serious problems the regional development confronts, by identifying these determining factors, they can be corrected more easily by implying massive efforts on a long time span

GENETIC VARIABILITY OF PHARMACOKINETICS AND PHARMACODYNAMICS OF ANALGESICS (LAYERED MEDICINE)

Pain therapy, the most widely spread disorder, tends more as other diseases, to administration of drug molecules targeted to the affected tissue at the right dose, or to the patient or patient groups (personalized medicine). A decisive determinant of this strategy is the genetic one, which is to some extent the basis of the variability of pharmacokinetic and pharmacodynamic response to analgesics in the patient population. The differences in action and response to analgesics are due in these cases to hyperfunctional or nonfunctional uni-nucleotide gene polymorphisms encoding enzyme-modified transport proteins or receptors involved in the biotransformation and dynamics of analgesics. Genomic testing increases therapeutic efficacy and avoids adverse effects especially in patients with long-term therapies.   &nbsp

GENETIC VARIABILITY OF PHARMACOKINETICS AND PHARMACODYNAMICS OF ANALGESICS (LAYERED MEDICINE)

Pain therapy, the most widely spread disorder, tends more as other diseases, to administration of drug molecules targeted to the affected tissue at the right dose, or to the patient or patient groups (personalized medicine). A decisive determinant of this strategy is the genetic one, which is to some extent the basis of the variability of pharmacokinetic and pharmacodynamic response to analgesics in the patient population. The differences in action and response to analgesics are due in these cases to hyperfunctional or nonfunctional uni-nucleotide gene polymorphisms encoding enzyme-modified transport proteins or receptors involved in the biotransformation and dynamics of analgesics. Genomic testing increases therapeutic efficacy and avoids adverse effects especially in patients with long-term therapies.   &nbsp

From classical to 3D archaeology

This paper aims to mark some of the possible applications of the engineering CAD software in the field of archeology. The archaeological information, which is usually stored in classical format, can be digitized in 3D by using CAD software. The result of this process can be used for multiple purposes : conservation, dissemination, research, etc.Neamtu Calin, Popescu Daniela, Mateescu Răzvan. From classical to 3D archaeology. In: Annales d'Université "Valahia" Târgovişte. Section d'Archéologie et d'Histoire, Tome 13, Numéro 1, 2011. pp. 79-88

THE IMPACT OF ADULT EDUCATION AND TRAINING ON SUSTAINABLE DEVELOPMENT AND TOURISM IN SUCEAVA COUNTY

In the context of knowledge economy, education is an important vector for creativity and innovation, to the extent that it is properly carried out on different levels, combining theory with practice. Nowadays, travel and tourism industry is, worldwide, the most dynamic sector and the most important generator of jobs. Since it creates an unprecedented number of jobs, tourism provides part-time and seasonal jobs for people looking for a flexible job. But lately, employers in the tourism field argue that one way to achieve sustained employment in this industry is implementing the ”multiple qualifications” policy, meaning that they are searching for staff with several trainings. The link between sustainable development and education is complex, as recent research has shown that education is helping countries meet their sustainable development goals

NEW MOLECULES USEFUL IN THE MIGRAINE TREATMENT

Migraine is a neurovascular condition characterized by episodes of severe headache with inter-individual variability. Inflammation of neurogenic origin contributes to the mechanism of occurrence of migraine and other primary headaches. Neurovascular headache is a condition in which neural events have as a result dilation of blood vessels and the appearance of painful sensation. CGRP (calcitonin-gene-related peptide) is a neuropeptide widespread both in the central and peripheral nervous system, being one of the most potent vasodilator substances with important role in controlling blood pressure in both normal and abnormal conditions. The releasing of perivascular peptides relaxes cerebral arteries while stimulating cAMP accumulation or release of EDRF (endothelium derived relaxing factor). An alternative to acute treatment of migraine used so far is the CGRP receptor blockade with selective antagonists. They represent potential therapeutic molecules with superior advantages to triptans and a longer duration of action