Synthesis and reactivity of cytotoxic platinum(II) complexes of bidentate oximes: a step towards the functionalization of bioactive complexes

Two new platinum(II) complexes bearing triphenylphosphine and bidentate oxime ligands [Pt(Cl)(PPh3){(κ2-N,O)-(1{C(R)=N(OH)-2(O)C10H6})}] (R = H, Me) were synthesized in good yields from trans-[PtCl(μ-Cl)(PPh3)]2. The structure of [Pt(Cl)(PPh3){(κ2-N,O)-(1{CH=N(OH)-2(O)C10H6})}] was determined by single-crystal X-ray diffraction. Both complexes showed good antiproliferative properties in vitro against HeLa, A2780, and A2780cis cancer cell lines. They reacted cleanly with alkylating agents in the presence of aqueous bases under phase-transfer catalysis conditions to afford the corresponding O-alkylation products [Pt(Cl)(PPh3){(κ2-N,O)-(1{HC=N(OR′)-2(O)C10H6})}] [R′ = CH2CH2Cl, CH2Ph, (CH2)4Br] in good yields

Создатели ядерного щита

The first example of a crystallographically established bis-adduct of tridentate 2,2':6',2:6',2"'-quaterpyridine (qtpy) of formula [Fe(qtpy)(2)][ClO4](2) has been obtained by treating an aqueous solution of iron(II) perchlorate with the ligand in the presence of triethylamine

Unprecedented pentanuclear mixed-valence Pt (II) -Pt (IV) complex anion in Q 2 [Pt 5 Cl 20 ] salts (Q = TBA, PPN)

Red crystals of [TBA]2[Pt5Cl20] were obtained by reacting [TBA]2[PtCl6] with an excess of AlCl3 at room temperature in CH2Cl2. The salt [PPN]2[Pt5Cl20] containing the same anion was prepared by reaction of platinum tetrachloride with a small excess of [PPN]Cl in 1,2-dichloroethane at room temperature. Single crystal X-Ray diffraction studies confirmed that both species contained the mixed-valence [Pt5Cl20]2– anion with two dinuclear platinum(IV) Pt2Cl10 fragments organized around a central square planar platinum(II) in a chair arrangement

New N,N-diisopropylcarbamato complexes of ruthenium(II) as catalytic precursors for olefin hydrogenation

During the synthesis of [Ru(O2CNiPr2)2(PPh3)2] (1), the [RuCl2(PPh3)3]/NHiPr2/CO2 system produces the intermediates [NH2iPr2][Ru2Cl2(μ-Cl)3(PPh3)4] (2) and [RuCl(O2CNiPr2)( PPh3)3] (3) which have been isolated and fully characterised. Compound 2 contains the dinuclear anionic triply chloride-bridged ruthenium(II) species. Compound 3 is mononuclear, the octahedral ruthenium centre being coordinated to the bidentate carbamato ligand. The reactions of compounds 1 and 3 with dihydrogen have been studied at room temperature and atmospheric pressure with respect to their catalytic hydrogenation of 1-octene