Hyperpolarized ^1H NMR employing low γ nucleus for spin polarization storage

The PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment)(1, 2) and DNP (Dynamic Nuclear Polarization)(3) methods efficiently hyperpolarize biologically relevant nuclei such as 1^H, (31)^P, (13)^C, (15)^N achieving signal enhancement by a factor of ~ 100000 on currently utilized MRI scanners. Recently, many groups have demonstrated the utility of hyperpolarized MR in biological systems using hyperpolarized (13)^C biomarkers with a relatively long spin lattice relaxation time T_1 on the order of tens of seconds.(4-7) Moreover, hyperpolarized (15)^N for biomedical MR has been proposed due to even longer spin lattice relaxations times.(8) An additional increase of up to tens of minutes in the lifetime of hyperpolarized agent in vivo could be achieved by using the singlet states of low gamma (γ) nuclei.(9) However, as NMR receptivity scales as γ^3 for spin 1/2 nuclei, direct NMR detection of low γ nuclei results in a lower signal-to-noise ratio compared to proton detection. While protons are better nuclei for detection, short spin lattice relaxation times prevent direct 1^H hyperpolarized MR in biomedical applications

Polarimetric variations of binary stars. II. Numerical simulations for circular and eccentric binaries in Mie scattering envelopes

We present numerical simulations of the periodic polarimetric variations produced by a binary star placed at the center of an empty spherical cavity inside a circumbinary ellipsoidal and optically thin envelope made of dust grains. Mie single-scattering is considered along with pre- and post-scattering extinction factors which produce a time-varying optical depth and affect the morphology of the periodic variations. We are interested in the effects that various parameters will have on the average polarization, the amplitude of the polarimetric variations, and the morphology of the variability. We show that the absolute amplitudes of the variations are smaller for Mie scattering than for Thomson scattering. Among the four grain types that we have studied, the highest polarizations are produced by grains with sizes in the range 0.1-0.2 micron. In general, the variations are seen twice per orbit. In some cases, because spherical dust grains have an asymmetric scattering function, the polarimetric curves produced also show variations seen once per orbit. Circumstellar disks produce polarimetric variations of greater amplitude than circumbinary envelopes. Another goal of these simulations is to see if the 1978 BME (Brown, McLean, & Emslie, ApJ, 68, 415) formalism, which uses a Fourier analysis of the polarimetric variations to find the orbital inclination for Thomson-scattering envelopes, can still be used for Mie scattering. We find that this is the case, if the amplitude of the variations is sufficient and the true inclinations is i_true > 45 deg. For eccentric orbits, the first-order coefficients of the Fourier fit, instead of second-order ones, can be used to find almost all inclinations.Comment: 23 pages, 5 figures, to be published in Astronomical Journa

Development of Container Free Sample Exposure for Synchrotron X-ray Footprinting.

The method of X-ray footprinting and mass spectrometry (XFMS) on large protein assemblies and membrane protein samples requires high flux density to overcome the hydroxyl radical scavenging reactions produced by the buffer constituents and the total protein content. Previously, we successfully developed microsecond XFMS using microfluidic capillary flow and a microfocused broadband X-ray source at the Advanced Light Source synchrotron beamlines, but the excessive radiation damage incurred when using capillaries prevented the full usage of a high-flux density beam. Here we present another significant advance for the XFMS method: the instrumentation of a liquid injection jet to deliver container free samples to the X-ray beam. Our preliminary experiments with a liquid jet at a bending magnet X-ray beamline demonstrate the feasibility of the approach and show a significant improvement in the effective dose for both the Alexa fluorescence assay and protein samples compared to conventional capillary flow methods. The combination of precisely controlled high dose delivery, shorter exposure times, and elimination of radiation damage due to capillary effects significantly increases the signal quality of the hydroxyl radical modification products and the dose-response data. This new approach is the first application of container free sample handling for XFMS and opens up the method for even further advances, such as high-quality microsecond time-resolved XFMS studies

Quasiparticle Interference on the Surface of the Topological Insulator Bi2_2Te3_3

The quasiparticle interference of the spectroscopic imaging scanning tunneling microscopy has been investigated for the surface states of the large gap topological insulator Bi$_2$Te$_3$ through the T-matrix formalism. Both the scalar potential scattering and the spin-orbit scattering on the warped hexagonal isoenergy contour are considered. While backscatterings are forbidden by time-reversal symmetry, other scatterings are allowed and exhibit strong dependence on the spin configurations of the eigenfunctions at k points over the isoenergy contour. The characteristic scattering wavevectors found in our analysis agree well with recent experiment results.Comment: 5 pages, 2 figures, Some typos are correcte

A New Experiment to Study Hyperon CP Violation and the Charmonium System

Fermilab operates the world's most intense antiproton source, now exclusively dedicated to serving the needs of the Tevatron Collider. The anticipated 2009 shutdown of the Tevatron presents the opportunity for a world-leading low- and medium-energy antiproton program. We summarize the status of the Fermilab antiproton facility and review physics topics for which a future experiment could make the world's best measurements.Comment: 16 pages, 3 figures, to appear in Proceedings of CTP symposium on Supersymmetry at LHC: Theoretical and Experimental Perspectives, The British University in Egypt, Cairo, Egypt, 11-14 March 200

Theory of the Three Dimensional Quantum Hall Effect in Graphite

We predict the existence of a three dimensional quantum Hall effect plateau in a graphite crystal subject to a magnetic field. The plateau has a Hall conductivity quantized at $\frac{4e^2}{\hbar} \frac{1}{c_0}$ with $c_0$ the c-axis lattice constant. We analyze the three-dimensional Hofstadter problem of a realistic tight-binding Hamiltonian for graphite, find the gaps in the spectrum, and estimate the critical value of the magnetic field above which the Hall plateau appears. When the Fermi level is in the bulk Landau gap, Hall transport occurs through the appearance of chiral surface states. We estimate the magnetic field necessary for the appearance of the three dimensional quantum Hall Effect to be $15.4$T for electron carriers and $7.0$T for hole carriers.Comment: Several new references adde

Reply to ``Comment on `Insulating Behavior of λ\lambda-DNA on the Micron Scale' "

In our experiment, we found that the resistance of vacuum-dried $\lambda$-DNA exceeds $10^{14} \Omega$ at 295 K. Bechhoefer and Sen have raised a number of objections to our conclusion. We provide counter arguments to support our original conclusion.Comment: 1 page reply to comment, 1 figur

Effective mass theory of monolayer \delta-doping in the high-density limit

Monolayer \delta-doped structures in silicon have attracted renewed interest with their recent incorporation into atomic-scale device fabrication strategies as source and drain electrodes and in-plane gates. Modeling the physics of \delta-doping at this scale proves challenging, however, due to the large computational overhead associated with ab initio and atomistic methods. Here, we develop an analytical theory based on an effective mass approximation. We specifically consider the Si:P materials system, and the limit of high donor density, which has been the subject of recent experiments. In this case, metallic behavior including screening tends to smooth out the local disorder potential associated with random dopant placement. While smooth potentials may be difficult to incorporate into microscopic, single-electron analyses, the problem is easily treated in the effective mass theory by means of a jellium approximation for the ionic charge. We then go beyond the analytic model, incorporating exchange and correlation effects within a simple numerical model. We argue that such an approach is appropriate for describing realistic, high-density, highly disordered devices, providing results comparable to density functional theory, but with greater intuitive appeal, and lower computational effort. We investigate valley coupling in these structures, finding that valley splitting in the low-lying \Gamma band grows much more quickly than the \Gamma-\Delta band splitting at high densities. We also find that many-body exchange and correlation corrections affect the valley splitting more strongly than they affect the band splitting

BoWFire: Detection of Fire in Still Images by Integrating Pixel Color and Texture Analysis

Emergency events involving fire are potentially harmful, demanding a fast and precise decision making. The use of crowdsourcing image and videos on crisis management systems can aid in these situations by providing more information than verbal/textual descriptions. Due to the usual high volume of data, automatic solutions need to discard non-relevant content without losing relevant information. There are several methods for fire detection on video using color-based models. However, they are not adequate for still image processing, because they can suffer on high false-positive results. These methods also suffer from parameters with little physical meaning, which makes fine tuning a difficult task. In this context, we propose a novel fire detection method for still images that uses classification based on color features combined with texture classification on superpixel regions. Our method uses a reduced number of parameters if compared to previous works, easing the process of fine tuning the method. Results show the effectiveness of our method of reducing false-positives while its precision remains compatible with the state-of-the-art methods.Comment: 8 pages, Proceedings of the 28th SIBGRAPI Conference on Graphics, Patterns and Images, IEEE Pres