<b>Average class probabilities by latent classes.</b>

<p><b>Average class probabilities by latent classes.</b></p

Trajectories for a hypothetical male of 60 years at time 0 of fasting plasma glucose (A), 2-hour plasma glucose (B), fasting serum insulin (C), and 2-hour serum insulin (D) from 18 years before time of diagnosis/last examination.

<p>Solid lines indicate estimated trajectories for each group and dashed lines are 95% confidence limits. Black bars at the bottom indicate the relative data distribution over the follow-up period. Light blue, stable overweight; dark blue, progressive weight gain; red, persistently obese; grey, diabetes-free population.</p

Flow diagram of the participants included at each phase.

<p>Flow diagram of the participants included at each phase.</p

Trajectories for a hypothetical male of 60 years at time 0 of HOMA-%B (A), HOMA-IR (B), Framingham 8-year diabetes risk (C), and Framingham 10-year CVD risk (D) from 18 years before time of diagnosis/last examination.

<p>Solid lines indicate estimated trajectories for each group and dashed lines are 95% confidence limits. Black bars at the bottom indicate the relative data distribution over the follow-up period. Light blue, stable overweight; dark blue, progressive weight gain; red, persistently obese; grey, diabetes-free population.</p

Trajectories for a hypothetical male, not on lipid-lowering treatment, age 60 years at time 0 of total cholesterol (A), HDL cholesterol (B), LDL cholesterol (C), and triglycerides (D) from 18 years before time of diagnosis/last examination.

<p>Solid lines indicate estimated trajectories for each group and dashed lines are 95% confidence limits. Black bars at the bottom indicate the relative data distribution over the follow-up period. Light blue, stable overweight; dark blue, progressive weight gain; red, persistently obese; grey, diabetes-free population.</p

Trajectories for a hypothetical male of 60 years at time 0 of body mass index (A), waist circumference (B), systolic blood pressure (C), and diastolic blood pressure (D) from 18 years before time of diagnosis/last examination.

<p>Trajectories for blood pressure represent a person not on anti-hypertensive treatment. Solid lines indicate estimated trajectories for each group and dashed lines are 95% confidence limits. Black bars at the bottom indicate the relative data distribution over the follow-up period. Trajectories of BMI for a hypothetical female of 50 years of age at time of diagnosis are shown in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001602#pmed.1001602.s001" target="_blank">Figure S1</a>. Light blue, stable overweight; dark blue, progressive weight gain; red, persistently obese; grey, diabetes-free population.</p

Beta coefficients and 95% confidence intervals for associations of non-standardised measures of VAT, SAT and body fat percentage with indices of glucose metabolism.

<p>Beta coefficients and 95% confidence intervals for associations of non-standardised measures of VAT, SAT and body fat percentage with indices of glucose metabolism.</p

Characteristics of the study sample.

<p>Characteristics of the study sample.</p

Incidence of all-cause mortality and a composite cardiovascular event among individuals diagnosed with clinically-incident diabetes between 2001 and 2009 in <i>ADDITION-Denmark</i> general practices, by trial group.

<p>Incidence of all-cause mortality and a composite cardiovascular event among individuals diagnosed with clinically-incident diabetes between 2001 and 2009 in <i>ADDITION-Denmark</i> general practices, by trial group.</p

Characteristics of individuals diagnosed with clinically-incident diabetes between 2001 and 2009 in <i>ADDITION-Denmark</i> general practices, by trial group.

<p>Characteristics of individuals diagnosed with clinically-incident diabetes between 2001 and 2009 in <i>ADDITION-Denmark</i> general practices, by trial group.</p