Mean right hemisphere surface maps of beta-band desynchronization (13–30 Hz) during the short condition standard tones.

<p>Mean right hemisphere surface maps of beta-band desynchronization (13–30 Hz) during the short condition standard tones.</p

Time-frequency analysis of target and standard tones for each trial type (long, short and pitch).

<p>Time-frequency analysis of target and standard tones for each trial type (long, short and pitch).</p

Time series of clusters of cortical activation for the standard tones from each condition.

<p>Time series of clusters of cortical activation for the standard tones from each condition.</p

Clusters of beta desynchronization as a function of volume, number of peaks, Brodmann areas, center of mass, and peak latency for the short tones.

<p>Clusters of beta desynchronization as a function of volume, number of peaks, Brodmann areas, center of mass, and peak latency for the short tones.</p

Results for a Repeated Measures ANOVA of Temporal Variability in Network Topology, measured using the CV.

<p>Results for a Repeated Measures ANOVA of Temporal Variability in Network Topology, measured using the CV.</p

Mean right hemisphere surface maps of beta-band desynchronization (13–30 Hz) during the long condition standard tones.

<p>Mean right hemisphere surface maps of beta-band desynchronization (13–30 Hz) during the long condition standard tones.</p

Entropy and Strength: Inter-Subject Level.

<p>Scatterplots of strength and complexity of the time series, as measured by wavelet entropy, for -, -, - and -bands. Single data points represent values for each individual averaged over trials and sensors. Red markers denote subjects with schizophrenia spectrum diagnosis; blue markers denote healthy subjects. Lines indicate best linear fits for the two groups separately (red, SZ; and blue, HC) and we provide values as indicators of goodness of fit. Similar scatterplots that code each experimental block separately are provided in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072351#pone.0072351.s001" target="_blank">Figure S1</a> in the SI.</p

Binary Network Organization in Health and Disease.

<p>(<i>A</i>–<i>B</i>) Example binary network diagnostic curves as a function of threshold: the modularity for controls (HC; black) and people with schizophrenia (SZ; red) (<i>A</i>), and the robustness to targeted attack for controls (black) and people with schizophrenia (blue) for -band networks. Individual curves indicate average values for each individual over the 66 trial-specific networks. (<i>C</i>) Significant group differences in graph diagnostic versus cost curves for 12 graph diagnostics (y-axis) in both intra- and inter-frequency bands (x-axis). Warm colors indicate that the diagnostics values were higher in people with schizophrenia than in healthy controls; cool colors indicate that the values were higher in healthy controls than in people with schizophrenia. Both warm and cool colors are two different shades corresponding to different levels of stringency for significance testing: false discovery rate (), and uncorrected (). See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072351#pone.0072351.s002" target="_blank">Figures S2</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0072351#pone.0072351.s003" target="_blank">S3</a> in the SI for the full graph diagnostic versus cost curves for all subjects, frequency bands, and diagnostics.</p

Group Differences in Activity and Connectivity.

<p>Wavelet entropy (<i>A</i>) and intra-frequency strength (<i>B</i>), averaged over sensors, in the -, -, - and -bands for healthy controls and people with schizophrenia. Asterisks indicate significant group differences as measured by non-parametric permutation tests (, corrected for multiple comparisons using the Holm-Bonferroni method).</p

Cost-Efficiency of Functional Networks in Health and Disease.

<p>(<i>A</i>) Cost-efficiency in the -, -, -, -, and cross-frequency band networks for healthy controls (blue) and people with schizophrenia (red). Error bars indicate the standard error over subjects. The gray shaded line indicates the expected values of cost-efficiency for an ensemble of random (ER) graphs (see Methods).</p