Linkage disequilibrium (LD) plot across the prolactin (PRL) locus for all racial/ethnic groups combined

<p><b>Copyright information:</b></p><p>Taken from "A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort"</p><p>http://www.biomedcentral.com/1471-2350/8/72</p><p>BMC Medical Genetics 2007;8():72-72.</p><p>Published online 1 Dec 2007</p><p>PMCID:PMC2219987.</p><p></p> The horizontal black line depicts the 59-kilobase region of chromosome (chr) 6 analyzed in our multiethnic panel. The PRL gene is shown in grey (RefSeq gene = completed genes from the human genome assembly). Alternative exon 1a (associated with the distal extra-pituitary promoter region) lies 5.8 kb upstream of exon 1 (associated with the pituitary promoter region). The 80 single nucleotide polymorphisms (SNPs) used for genetic characterization are listed below the black line. The LD plot, presented at the bottom of the figures, is based on the measure of '. Each diamond indicates the pairwise magnitude of LD, with dark grey indicating strong LD (' > 0.8) and a logarithm of odds score of greater than 2.0. (Figure prepared with LocusView, Broad Institute, Cambridge, MA, unpublished software by T. Petryshen, A. Kirby, and M. Ainscow [61])

Linkage disequilibrium (LD) plot across the prolactin receptor (PRLR) locus for all racial/ethnic groups combined

<p><b>Copyright information:</b></p><p>Taken from "A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort"</p><p>http://www.biomedcentral.com/1471-2350/8/72</p><p>BMC Medical Genetics 2007;8():72-72.</p><p>Published online 1 Dec 2007</p><p>PMCID:PMC2219987.</p><p></p> The horizontal black line depicts the 210-kilobase region of chromosome (chr) 5 analyzed in our multiethnic panel. The PRLR gene is shown in grey (RefSeq gene = completed genes from the human genome assembly). Alternative first exons are shown in black below the gene: hE13, hE1N1, hE1N2, hE1N3, hE1N4, and hE1N5. The 173 single nucleotide polymorphisms (SNPs) used for genetic characterization are listed below the black line. The LD plot, presented at the bottom of the figures, is based on the measure of '. Each diamond indicates the pairwise magnitude of LD, with dark grey indicating strong LD (' > 0.8) and a logarithm of odds score of greater than 2.0. (Figure prepared with LocusView, Broad Institute, Cambridge, MA, unpublished software by T. Petryshen, A. Kirby, and M. Ainscow [61])

A Scale Map of the 26 SNPs Genotyped in the MEC Screening Panel and a Plot of the Pattern of Linkage Disequilibrium among Them (in Whites)

<p>The four tag SNPs are markers with arrows, and the block of high linkage disequilibrium and limited haplotype diversity spanning <i>HSD17B1</i> is highlighted.</p